Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective Cohort Study

Nonarteritic anterior ischaemic optic neuropathy and its association with obstructive sleep apnoea: a health insurance database study

“…Although the incidence of NAION has been shown to be lower in the age 30–39 years compared to other older groups (age 30–39 years: 2.3, age 40–49 years: 5.2, age 50–59 years: 9.44; age ≥60 years: 14.79 per 100 000 Person‐Years, respectively) (Lee et al. ), our study showed the first time that the patients with OSA aged 30–39 years had a significantly higher risk of developing NAION than those in other age groups (HR: 6.30, p < 0.01), But in the years 40–69, which account for a large portion of our NAION patients, there is no difference in rates and risk of NAION between the OSA group and control group. There are some explanations for these findings.…”

Prevalence and incidence of non-arteritic anterior ischaemic optic neuropathy in South Korea: a nationwide population-based study

“…Based on nationally representative estimates from 1 381 477 eligible enrollees aged 40–75 years in the USA, 977 (0.1%) developed NAION 5. According to representative data from NHI in Taiwan, the prevalence of NAION during 2 years was 48.18 (0.05%) per 100 000 10. Although the prevalence of NAION in South Korea was higher than in Taiwan, it should be noted that a direct comparison could be difficult because of differences in methodology and population characteristics.…”

“…However, the authors commented that the estimate was unreliable because of the misdiagnosis of other optic neuropathies 11. Regarding estimates in Asian populations, Xu et al reported an annual incidence rate of 6.3 per 100 000 for patients older than 40 years of age in a Beijing eye study,4 and Lee  et al documented a 12.1 per 100 000 incidence rate among people older than 50 years in a Taiwan study 10. The incidence rate of the present study was a bit higher than that found in these previous studies.…”

Therapeutic Effects of Puerarin Against Anterior Ischemic Optic Neuropathy Through Antiapoptotic and Anti-Inflammatory Actions

“…N onarteritic anterior ischemic optic neuropathy (NAION) is the most common form of acute optic neuropathy in aged people, with an estimated annual incidence of 2.3 to 10.2 per 100,000 people in the United States and Taiwan, at least 6000 new cases a year. [1][2][3][4] NAION is characterized clinically by acute, painless, visual loss with swelling of the optic disc leading to optic disc atrophy. 5 The most common pathogenesis of NAION is caused by transient nonperfusion or hypoperfusion of the optic nerve head (ONH).…”