Increased risk of soft tissue sarcoma after radiotherapy in women with breast carcinoma

Huang, Junhua; Mackillop, W.

doi:10.1002/1097-0142(20010701)92:1<172::aid-cncr1306>3.0.co;2-k

Cited by 251 publications

(195 citation statements)

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“…In a cohort study of breast cancer patients, the RR of angiosarcoma after radiotherapy reached its maximum during 5 -10 years of follow-up (Huang and Mackillop, 2001). Our study indicates an increased angiosarcoma risk after 10 years both after radiotherapy and other treatments.…”

Section: Discussionmentioning

confidence: 52%

“…In a SEER data study of second malignancies among 270 000 breast cancer patients, angiosarcomas were found to comprise 56.8% of the sarcomas occurring in the field of prior radiation (Yap et al, 2002). In a population-based retrospective cohort study of 195 000 breast carcinoma patients, an increased risk of soft tissue sarcoma was found, especially for angiosarcoma: SIR 26.2 (95% CI 16.5 -41.4) in the radiotherapy cohort with an increased relative risk (RR 15.9, 95% CI 6.6 -38.1) compared to those not so treated (Huang and Mackillop, 2001); the SIRs were lower in our study, with no excess after radiotherapy compared with other treatments.…”

Section: Discussionmentioning

confidence: 99%

“…In our previous study, radiotherapy was found to be a risk factor for subsequent bone and soft tissue sarcoma (Virtanen et al, 2006). Ionising radiation is one of the few known causes of angiosarcoma (Miller et al, 1996;Zahm et al, 1996;Huang and Mackillop, 2001;Fletcher et al, 2002;Yap et al, 2002). We have investigated the risk of angiosarcoma in relation to chemotherapy and radiotherapy in a large, populationbased cohort of cancer patients.…”

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confidence: 97%

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Angiosarcoma after radiotherapy: a cohort study of 332 163 Finnish cancer patients

2007

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We evaluated the risk of angiosarcoma after radiotherapy among all patients with cancers of breast, cervix uteri, corpus uteri, lung, ovary, prostate, or rectum, and lymphoma diagnosed in Finland during 1953Finland during -2003, identified from the Finnish Cancer Registry. Only angiosarcomas of the trunk were considered, this being the target of radiotherapy for the first cancer. In the follow-up of 1.8 million person-years at risk, 19 angiosarcomas developed, all after breast and gynaecological cancer. Excess of angiosarcomas over national incidence rates were observed after radiotherapy without chemotherapy (standardised incidence ratio (SIR) 6.0, 95% confidence interval (CI) 2.7 -11), after both radiotherapy and chemotherapy (SIR 100, 95% CI 12 -360), and after other treatments (SIR 3.6, 95% CI 1.6 -7.1). In the regression analysis however, the adjusted rate ratio for radiotherapy was 1.0 (95% CI 0.23 -4.4). Although an increased risk of angiosarcoma among cancer patients is evident, especially with breast and gynaecological cancer, the excess does not appear to be strongly related to radiotherapy.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

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confidence: 97%

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Angiosarcoma after radiotherapy: a cohort study of 332 163 Finnish cancer patients

2007

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“…The exact etiology is still not completely understood, but the presence of lymphedema (11,12), radiogenic DNA mutations (12), and a genetic predisposition (2) are suggested as causative factors for developing secondary angiosarcoma, as well as congenital, idiopathic, and traumatic factors (1). Likely, these factors have a synergistic effect (11).…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma of the Breast

Lim¹,

Goei²

2007

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“…Radiotherapy is an independent aetiological factor with a peak incidence 10 years after treatment [81]. There are also case reports suggesting mutations in the DNA repair proteins, BRCA 1 and BRCA 2, predispose to the development of angiosarcoma following breast cancer therapy [82].…”

Section: Aetiologymentioning

confidence: 99%