Increased risk of preneoplastic colonic lesions and colorectal carcinoma in acromegaly: multicenter case–control study

Battistone, María Florencia; Miragaya, Karina; Rogozinski, Amelia; Agüero, M. Barrio Gómez de; Alfieri, Analía; Ballarino, María Carolina; Boero, Laura; Danilowicz, Karina; Diez, Sabrina; Donoso, M.; Fainstein-Day, Patricia; Furioso, Alejandra; García-Basavilbaso, Natalia; Glerean, Mariela; Katz, Débora; Loto, Monica; Mallea-Gil, Susana; Martínez, Marcela; Sabaté, Maria; Servidio, Marisa; Slavinsky, Patricia; Stalldecker, Graciela; Sosa, Soledad; Szuman, Grabriela; Tkatch, Julieta; Caldo, Ignacio; Lubieniecki, Daniela; Guitelman, Mirtha

doi:10.1007/s11102-020-01090-8

Cited by 10 publications

(14 citation statements)

References 43 publications

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“…The link between acromegaly and the development of benign and malignant CRCs (mainly adenocarcinoma) has also been confirmed in the Japanese cohort study [ 184 ]. Such a link is also supported by the only available meta-analysis [ 185 ], as well as most recent multicenter case-control retrospective study [ 177 ]. The first work showed that patients with acromegaly have an increased risk of developing both colorectal adenomatous and hyperplastic polyps as well as CRC.…”

Section: Igf-1 and Colorectal Cancer Pathogenesismentioning

confidence: 80%

“…As research shows, one of acromegalic comorbidities are different malignancies, including CRC [ 174 , 176 , 177 ]. Fasting insulin and HOMA-IR levels correlate positively with hyperplastic polyps and adenomas in patients with acromegaly with divisive changes in the large intestine [ 178 ].…”

Section: Igf-1 and Colorectal Cancer Pathogenesismentioning

confidence: 99%

“…A recent study on 70 acromegalic patients confirmed an increased risk of preneoplastic colonic alterations and CRCs in patients with chronic and sustained GH excess vs. control group. IR, on the other hand, was the only statistically significant factor in acromegalic patients with and without colonic polyps [ 177 ]. The increased risk of colorectal neoplasia in acromegalic patients is due to e.g., excessive production of GH and IGF-1, resulting in increased proliferation of colon cells and decreased apoptosis ratio.…”

Section: Igf-1 and Colorectal Cancer Pathogenesismentioning

confidence: 99%

“…The high blood glucose levels that occur in obese subjects with MetS, DM II, or prediabetes IR provide a promoting environment for the development and metabolic “engine” of cancer, including CRC [ 12 , 13 , 214 ]. Numerous studies also indicate a link between hyperinsulinemia, IR and colonic pre- and neoplastic lesions in acromegalic patients [ 174 , 176 , 177 , 178 ]. The choice of treatment for acromegaly should take into account the alleviation of glucose metabolism disorders, by reversing IR and reducing gluconeogenesis, e.g., by normalizing GH/IGF-1 levels [ 175 , 176 ].…”

Section: Therapeutic Strategies For Reduction Of Metabolic Glucose Disorders In Crcmentioning

confidence: 99%

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Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer

Kasprzak

2021

IJMS

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Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide, characterized by unfavorable curative effect and poor prognosis. Epidemiological data re-vealed that CRC risk is increased in patients with metabolic syndrome (MetS) and its serum components (e.g., hyperglycemia). High glycemic index diets, which chronically raise post-prandial blood glucose, may at least in part increase colon cancer risk via the insulin/insulin-like growth factor 1 (IGF-1) signaling pathway. However, the underlying mechanisms linking IGF-1 and MetS are still poorly understood. Hyperactivated glucose uptake and aerobic glycolysis (the Warburg effect) are considered as a one of six hallmarks of cancer, including CRC. However, the role of insulin/IGF-1 signaling during the acquisition of the Warburg metabolic phenotypes by CRC cells is still poorly understood. It most likely results from the interaction of multiple processes, directly or indirectly regulated by IGF-1, such as activation of PI3K/Akt/mTORC, and Raf/MAPK signaling pathways, activation of glucose transporters (e.g., GLUT1), activation of key glycolytic enzymes (e.g., LDHA, LDH5, HK II, and PFKFB3), aberrant expression of the oncogenes (e.g., MYC, and KRAS) and/or overexpression of signaling proteins (e.g., HIF-1, TGF-β1, PI3K, ERK, Akt, and mTOR). This review describes the role of IGF-1 in glucose metabolism in physiology and colorectal carcinogenesis, including the role of the insulin/IGF system in the Warburg effect. Furthermore, current therapeutic strategies aimed at repairing impaired glucose metabolism in CRC are indicated.

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Section: Igf-1 and Colorectal Cancer Pathogenesismentioning

confidence: 80%

Section: Igf-1 and Colorectal Cancer Pathogenesismentioning

confidence: 99%

Section: Igf-1 and Colorectal Cancer Pathogenesismentioning

confidence: 99%

Section: Therapeutic Strategies For Reduction Of Metabolic Glucose Disorders In Crcmentioning

confidence: 99%

See 2 more Smart Citations

Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer

Kasprzak

2021

IJMS

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“…[38]. In 2018, Dal et al published a cohort study and a meta-analysis of the literature to reinforce the cohort research's findings.…”

mentioning

confidence: 99%

Acromegaly and the Colon: Scoping Beyond the Pituitary

Patel¹,

Grossmann²,

Rodriguez³

et al. 2021

Cureus

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Acromegaly is a complex endocrinological disorder commonly caused by hypersecretion of growth hormone (GH) typically due to pituitary gland tumors. Patients with acromegaly who are successfully treated and biochemically managed have a reasonably average life expectancy. However, it causes a cascade of multisystemic involvement throughout the patient's life, including cardiovascular, neuropsychiatric, respiratory, metabolic, neurological, neoplastic, and gastrointestinal involvement, resulting in a higher rate of hospitalization, lower quality of life, and a shorter life expectancy. Although cardiovascular complications are the primary cause of death in patients with acromegaly, malignancy is now emerging as a major killer in these individuals. Colorectal carcinoma has been reported to be prevalent in acromegaly individuals. This review article has compiled studies to demonstrate a link between acromegaly and colorectal neoplasia, intending to provide a strong foundation for their clinical relationship. This article has summarised a potential pathogenic mechanism and provided insights into the clinical presentation of such patients. Furthermore, this article has provided a brief overview of current screening recommendations for colorectal neoplasia in acromegaly patients.

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Cancer prevalence and cancer screening in patients with acromegaly: a single center experience

et al. 2022

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Increased risk of preneoplastic colonic lesions and colorectal carcinoma in acromegaly: multicenter case–control study

Cited by 10 publications

References 43 publications

Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer

Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer

Acromegaly and the Colon: Scoping Beyond the Pituitary

Cancer prevalence and cancer screening in patients with acromegaly: a single center experience

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