Increased risk of osteoporotic fractures in patients with systemic sclerosis: a nationwide population-based study

Lai, Chih-Sheng; Wang, Shu Hung; Chen, Wei Sheng; Liu, Chia Jen; Chen, Tzeng Ji; Lee, Pui Ching; Chang, Yu Sheng

doi:10.1136/annrheumdis-2013-204832

Cited by 31 publications

(29 citation statements)

References 25 publications

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“…Thus, all results could be applicable to this category of patients. The main limitation of our study is the small size of our population ( n = 33) as compared to a nationwide population-based study [ 33 ]. However, SSc is a rare disease and the number of included patients in our study is relative, compared to the number of previous studies concerned with bone damage in SSc.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, GC did not appear in any of our models as an explanatory factor. There is a scientific debate about the impact of GC on BMD and OP in SSc: it has been showed that GC did not influence the occurrence of OP in SSc [ 34 ] and that cumulative GC doses did not differ between women with or without osteoporosis fractures, which is in contrast with the role of GC in the occurrence of fractures reported by Lai et al [ 33 ].…”

Section: Methodsmentioning

confidence: 99%

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Prevalence and predictive factors of osteoporosis in systemic sclerosis patients: a case-control study

et al. 2015

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PurposeInvestigate the prevalence of osteoporosis in patients with systemic sclerosis (SSc) and describe alterations of bone tissue with High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT).MethodsThirty-three patients and 33 controls matched on age, body mass index (BMI) and menopause were included. Bone mineral density (BMD) was measured at the lumbar spine (LS), femoral neck (FN) and total hip (TH) by dual energy X-ray absorptiometry. Volumetric BMD (vBMD) and bone microarchitecture were measured by HR-pQCT at tibia and radius.ResultsIn patients, BMI was significantly lower, the prevalence of osteoporosis was significantly higher and HR-pQCT analysis showed a significant alteration of the trabecular compartment with a decrease in trabecular vBMD on both sites than in controls. In multivariate analysis, a low lean body mass, presence of anticentromere antibodies and older age were identified as independent factors for decreased BMD at LS (r²=0.43), FN (r²=0.61) and TH (r²=0.73). History or current digital ulcers were also identified as an independent factor for microarchitecture alteration.ConclusionIn patients an increased prevalence of osteoporosis was found and HR-pQCT showed impaired trabecular bone compartment. Also, low lean body mass, high age, digital ulcers and ACAs were identified as independent risk factors for bone damage.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Prevalence and predictive factors of osteoporosis in systemic sclerosis patients: a case-control study

et al. 2015

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“…[13] при обследовании 61 женщины с ССД в возрасте 26-51 года и 60 больных в постменопаузе не наблюдали ассоциации снижения МПКТ с предыдущим приемом ГКС во всех возрастных группах больных. Вместе с тем в большом популяционном исследовании, проведенном в Тайване и включавшем 1712 больных ССД (79% женщин), многофакторный регрессионный анализ показал тесную связь приема ГКС в суточной дозе >7,5 мг с развитием ОП и остеопоротических переломов у больных ССД [29].…”

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Bone mineral density in patients with scleroderma systematica

et al. 2016

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“…The Ministry also established the NHI database which has collected the dates of birth, the diagnoses of patients, the dates of doctor’s visits, sex, and other related information of patients. Numerous studies utilize this database to survey the risk of comorbidities in diseases including systemic sclerosis and Crohn’s disease [ 7 , 8 ].…”

Section: Methodsmentioning

confidence: 99%

Reduced incidence of Crohn’s disease in systemic sclerosis: a nationwide population study

Tseng

Yen

Tsai

et al. 2015

BMC Musculoskelet Disord

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BackgroundTo date, there has been no studies to evaluate the incidence of Crohn’s disease in systemic sclerosis patients. The goals of this study were to evaluate the incidence of Crohn’s disease and its relationship with sex and age in patients with systemic sclerosis.MethodsWe enrolled patients with systemic sclerosis and controls from Taiwan’s Registry of Catastrophic Illness Database and National Health Insurance Research Database. Every systemic sclerosis patient was matched to at most three controls by sex, age, month and year of initial diagnosis of systemic sclerosis. The standardized incidence ratio (SIR) of Crohn’s disease in systemic sclerosis patients, and 95 % confidence interval (95 % CI) were calculated. Cox hazard regression was used to calculate the hazard ratio (HR).ResultsThe study enrolled 2,829 patients with systemic sclerosis and 8,257 controls. Male and female patients with systemic sclerosis both had lower rates of incident Crohn’s disease (SIR: 0.18, 95 % CI = 0.05–0.62; SIR: 0.10, 95 % CI = 0.05–0.21, respectively). The risk of incident Crohn’s disease in systemic sclerosis was still lower than in controls when we stratified the patients according to their ages. In Cox hazard regression, the hazard rates of Crohn’s disease were lower in systemic sclerosis patients after adjusting for genders and ages (HR: 0.12, 95 % CI = 0.06–0.21, p < 0.001).ConclusionsSystemic sclerosis is associated with decreased incidence of, irrespective of sex and age of the patients.

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Increased risk of osteoporotic fractures in patients with systemic sclerosis: a nationwide population-based study

Abstract: SSc patients had a high IR of vertebral and hip fractures, especially those who were female, older, used a high dose of corticosteroid or experienced bowel dysmotility.

Cited by 31 publications

References 25 publications

Prevalence and predictive factors of osteoporosis in systemic sclerosis patients: a case-control study

Prevalence and predictive factors of osteoporosis in systemic sclerosis patients: a case-control study

Bone mineral density in patients with scleroderma systematica

Reduced incidence of Crohn’s disease in systemic sclerosis: a nationwide population study

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