Increased risk of dementia after distal radius, hip, and spine fractures

Kim, So Young; Lee, Joon Kyu; Lim, Jae-Sung; Park, Bumjung; Choi, Hyo Geun

doi:10.1097/md.0000000000019048

Cited by 18 publications

(21 citation statements)

References 32 publications

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“…The association between fracture and dementia may be contributed to shared risk factors including APOE4, low levels of physical activity, and vitamin D. 33 Whilst fracture as an independent risk factor of dementia has been reported in several studies. 34 , 35 Respiratory disorders (COPD and asthma) were also linked to increased dementia in our study. Although the underlying mechanisms are unclear, our study is supported by recent evidence that poor pulmonary function might accelerate cognitive decline.…”

Section: Discussionsupporting

confidence: 56%

Association of a wide range of chronic diseases and apolipoprotein E4 genotype with subsequent risk of dementia in community-dwelling adults: A retrospective cohort study

et al. 2022

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Section: Discussionsupporting

confidence: 56%

Association of a wide range of chronic diseases and apolipoprotein E4 genotype with subsequent risk of dementia in community-dwelling adults: A retrospective cohort study

et al. 2022

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“…One and a half mn hip fractures occur per year and this number will continue to increase to 4.5 mn by 2050 4 . Dementia patients had an odds ratio of 6.9 to develop hip fractures, and hip fractures could also in turn increase the risk of dementia 5 . The recent study showed that antipsychotic drugs were associated with an increased risk of hip fractures among dementia patients 6 and elderly dementia adults needed home care services more often than elderly adults who did not have dementia 7 .…”

Section: Introductionmentioning

confidence: 99%

Early Detection of Pneumonia with the Help of Dementia in Geriatric Hip Fracture Patients

Tang

Li²,

Liu³

et al. 2022

Orthopaedic Surgery

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Objective To investigate the role of dementia in pneumonia among geriatric patients with hip fracture and further develop an algorithm for stratifying risk of developing postoperative pneumonia. Methods The algorithm was developed after retrospectively analyzing 1344 hip fracture patients in the National Clinical Research Center for Orthopedics, Sports Medicine, and Rehabilitation from 1992 to 2012. Twenty‐eight variables were analyzed for evaluating the ability to predict postoperative pneumonia. The validation of the algorithm was performed in the MIMIC‐III database after enrolling 235 patients. Results One thousand five hundred and seventy‐nine patients were enrolled, 4.69% patients had postoperative pneumonia in our hospital, and 17.02% suffered pneumonia in the MIMIC‐III database. Dementia patients had more postoperative pneumonia (12.68% vs 4.24%, P = 0.0075), as compared with patients without dementia. The algorithm included nine predictors: dementia, age, coronary heart disease, the American Society of Anesthesiologists score, surgical method, mechanical ventilation, anemia, hypoproteinemia, and high creatinine. Internal validation showed the algorithm with dementia could improve predictive performance, while external validation found the algorithm with or without dementia both had similar and good predictive ability. Conclusions The algorithm has the potential to be a pragmatic risk prediction tool to calculate risk of pneumonia in clinical practice and it may also be applicable in critically ill hip fracture patients with dementia.

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“…The main cause lies in the delirium that some of these patients experience during the postoperative period, which is estimated to increase the risk of developing dementia by up to 15 times in the 3 years after the fracture 16 . In addition, other factors have been related, such as the inflammatory response during the fracture consolidation process, the alteration of motor function and a decrease in physical activity after it, and the medication they receive during the process -before, during and after surgery-which could influence impairment 17 .…”

Section: Discussionmentioning

confidence: 99%

Impacto de la demencia en la supervivencia de los pacientes con fractura de cadera intervenidos mediante prótesis total y parcial

Etxebarría-Foronda

Larrañaga

Ibarrondo

et al. 2021

Rev Osteoporos Metab Miner

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Objetive: To carry out a comparative survival analysis of patients diagnosed with hip fractures (HF) in the Basque Health Service from 2010 to 2016 depending on whether or not they were diagnosed with dementia and the type of arthroplasty. Material and methods:Observational study (real world data) of survival. The data were obtained from the administrative and clinical databases of the Basque Health Service using the Oracle Business Intelligence (OBI) manager. All cases of femur neck fractures from 2010 to 2016 were analyzed in the Basque Health Service. A descriptive analysis was carried out to detect differences between groups according to previous diagnosis of dementia and type of prosthesis. The Kaplan-Meier method was used to obtain the survival curves and their comparison was made in pairs using the Achievement test. The adjusted risk of death for each group was analyzed with the Cox regression model. Results: 5,867 patients with CF were identified, being 1,131 patients without dementia and total prosthesis, 3,073 without dementia and partial prosthesis, 176 with dementia and total prosthesis and 1,487 with dementia and partial prosthesis. The median survival was 9.08 years, 3.79 years, 2.55 years, and 2.54 years respectively. The comparison of the survival curves was significant for all cases except between the last two groups. Using the first group as a reference, the odds ratio of death for the rest was 1.56, 2.27 and 2.37 respectively. When analyzing the risk of death only for patients with dementia, the type of prosthesis was not statistically significant. Conclusions: Dementia influences the survival curve of patients who undergo arthroplasty after a femur neck fracture, with those who undergo a total arthroplasty have a similar mortality rate as those who undergo partial arthroplasty.

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Increased risk of dementia after distal radius, hip, and spine fractures

Abstract: Supplemental Digital Content is available in the text

Cited by 18 publications

References 32 publications

Association of a wide range of chronic diseases and apolipoprotein E4 genotype with subsequent risk of dementia in community-dwelling adults: A retrospective cohort study

Association of a wide range of chronic diseases and apolipoprotein E4 genotype with subsequent risk of dementia in community-dwelling adults: A retrospective cohort study

Early Detection of Pneumonia with the Help of Dementia in Geriatric Hip Fracture Patients

Impacto de la demencia en la supervivencia de los pacientes con fractura de cadera intervenidos mediante prótesis total y parcial

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