Increased risk of contralateral breast cancers among overweight and obese women: a time-dependent association

Majed, Bilal; Dozol, Adrien; Ribassin-Majed, Laureen; Senouci, Kamel; Asselain, Bernard

doi:10.1007/s10549-010-1153-z

Cited by 34 publications

(30 citation statements)

References 33 publications

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“…The current literature suggests also the following predictive factors for bilateral breast cancer development: BC familial history [7, 25, 27], BRCA gene mutations [38], HER-2/Neu positivity [39], overweight [40], lobular histology [3, 41], and metropolitan residence, being this last probably due to a better access to the mammographic screening [25]. In fact, also in our study second MBCs and SBCs were more likely to be discovered by mammography.…”

Section: Discussionmentioning

confidence: 99%

Synchronous and Metachronous Breast Malignancies: A Cross-Sectional Retrospective Study and Review of the Literature

Londero

Bernardi

Bertozzi

et al. 2014

BioMed Research International

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Objective. There is increasing interest in patients with metachronous (MBC) and synchronous breast cancer (SBC). The objective of this study was to evaluate the occurrence and outcome of MBCs and SBCs. Methods. A retrospective study on women operated in our department for breast cancer between 2002 and 2005 was carried out. Patients were divided into three groups: women with MBC, SBC, and unilateral breast cancer (UBC). Moreover, we performed a meta-analysis of the English literature about multiple breast cancers between 2000 and 2011 taking into consideration their prevalence and overall survival (OS). Results. We identified 584 breast cancer patients: 16 women (3%) presented SBC and 40 MBC (7%, second cancer after 72-month follow-up IQR 40–145). Although the meta-analysis showed significant OS differences between MBC or SBC and UBC, we did not observe any significant OS difference among the three groups of our population. Anyway, we found a significant worse disease-free survival in MBC than UBC and a significant higher prevalence of radical surgery in MBC and SBC than UBC. Conclusions. Despite the low prevalence of MBC and SBC, the presence of a long time risk of MBC confirms the crucial role of ipsi- and contralateral mammographies in the postoperative follow-up.

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Section: Discussionmentioning

confidence: 99%

Synchronous and Metachronous Breast Malignancies: A Cross-Sectional Retrospective Study and Review of the Literature

Londero

Bernardi

Bertozzi

et al. 2014

BioMed Research International

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“…Few studies have explored the association between BMI and CBC risk and the results have been inconsistent [11–18, 20]. Even fewer studies have examined whether hormone receptor status of the first primary tumor influenced this relationship [15, 16, 18].…”

Section: Discussionmentioning

confidence: 99%

“…Limitations include the lack of data on physical activity, limited number of women with ER-negative first breast cancers, incomplete data on ER-status of the second primary breast cancer in cases, and insufficient sample size to examine the relationship between BMI and CBC risk after excluding women who received hormonal treatment. The short interval between first diagnosis and CBC prevented assessing the impact of long-term weight-change on risk or of evaluating whether BMI might affect CBC risk at longer intervals as found by Majed et al [20]. …”

Section: Discussionmentioning

confidence: 99%

Body mass index and risk of second primary breast cancer: The WECARE Study

Brooks

John

Mellemkjær

et al. 2011

Breast Cancer Res Treat

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The identification of potentially modifiable risk factors, such as body size, could allow for interventions that could help reduce the burden of contralateral breast cancer (CBC) among breast cancer survivors. Studies examining the relationship between body mass index (BMI) and CBC have yielded mixed results. From the population-based, case–control, Women's Environmental, Cancer and Radiation Epidemiology (WECARE) Study, we included 511 women with CBC (cases) and 999 women with unilateral breast cancer (controls) who had never used postmenopausal hormone therapy. Rate ratios (RR) and 95% confidence intervals (CI) were used to assess the relationship between BMI and CBC risk. No associations between BMI at first diagnosis or weight-change between first diagnosis and date of CBC diagnosis (or corresponding date in matched controls) and CBC risk were seen. However, obese (BMI ≥ 30 kg/m2) postmenopausal women with estrogen receptor (ER)-negative first primary tumors (n = 12 cases and 9 controls) were at an increased risk of CBC compared with normal weight women (BMI < 25 kg/m2) (n = 43 cases and 98 controls) (RR = 5.64 (95% CI 1.76, 18.1)). No association between BMI and CBC risk was seen in premenopausal or postmenopausal women with ER-positive first primaries. Overall, BMI is not associated with CBC risk in this population of young breast cancer survivors. Our finding of an over five-fold higher risk of CBC in a small subgroup of obese postmenopausal women with an ER-negative first primary breast cancer is based on limited numbers and requires confirmation in a larger study.

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“…The same study as well as several other case-control [6,19] and cohort [20] investigations reported a direct association between adult weight gain and postmenopausal breast cancer risk. The contralateral breast cancer risk is also higher in obese postmenopausal women [21]. There is, therefore, convincing evidence that, as compared with normal weight women, the RR for postmenopausal breast cancer is around 1.5 for overweight women (BMI, 25 kg/m 2 to 30 -32 kg/ m 2 ) and Ͼ2 for obese women, and that the association is stronger in elderly women.…”

Section: Obesity Diabetes and Breast Cancermentioning

confidence: 96%

Overweight, Obesity, Diabetes, and Risk of Breast Cancer: Interlocking Pieces of the Puzzle

et al. 2011

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We considered epidemiological data on overweight, diabetes, insulin, and breast cancer. Overweight is inversely related to premenopausal breast cancer, but there is definite evidence that, as compared with normal weight women, the relative risk (RR) for postmenopausal breast cancer is around 1.5 for overweight women and >2 for obese women, and that the association is stronger in elderly women. Overweight and obesity are strongly related to diabetes. Diabetes is associated with postmenopausal breast cancer, too, with summary RRs from meta-analyses of 1.15-1.20, but not with premenopausal breast cancer (RR, 0.9). There is no consistent evidence that fasting insulin is related to breast cancer risk. Thus, although overweight and obesity are strongly related to postmenopausal breast cancer, diabetes is only moderately related to it. Given the extent of the association, and the likely residual confounding by overweight, inference on causality for the diabetes-breast cancer relation remains open to discussion. The Oncologist 2011;16:726 -729

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Increased risk of contralateral breast cancers among overweight and obese women: a time-dependent association

Abstract: Increased risk of contralateral breast cancers among overweight and obese women: a time-dependent association.

Cited by 34 publications

References 33 publications

Synchronous and Metachronous Breast Malignancies: A Cross-Sectional Retrospective Study and Review of the Literature

Synchronous and Metachronous Breast Malignancies: A Cross-Sectional Retrospective Study and Review of the Literature

Body mass index and risk of second primary breast cancer: The WECARE Study

Overweight, Obesity, Diabetes, and Risk of Breast Cancer: Interlocking Pieces of the Puzzle

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