Increased Risk of Chronic Obstructive Pulmonary Disease in Patients with Hyperlipidemia: A Nationwide Population-Based Cohort Study

Yang, Hao-Yu; Hu, Li-Yu; Chen, Hon-Jhe; Chen, Ru-Yih; Hu, Chang-Kuo; Shen, Cheng Che

doi:10.3390/ijerph191912331

Cited by 4 publications

(3 citation statements)

References 57 publications

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“…This is consistent with a cross‐sectional analysis of Israeli adults, which demonstrated an inverse association between low HDL cholesterol levels and COPD, along with high triglyceride levels 41 . Another retrospective cohort study conducted in Taiwan, which predominantly included Asian participants, also reported a 1.48‐fold increased risk of subsequent COPD development in individuals with hyperlipidaemia 42 . However, we did not find a significant association between elevated triglyceride concentration and COPD.…”

Section: Discussionsupporting

confidence: 90%

“…41 Another retrospective cohort study conducted in Taiwan, which predominantly included Asian participants, also reported a 1.48-fold increased risk of subsequent COPD development in individuals with hyperlipidaemia. 42 However, we did not find a significant association between elevated triglyceride concentration and COPD. The disparity in results may be attributed to ethnic differences.…”

Section: Discussioncontrasting

confidence: 76%

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Metabolic syndrome, genetic susceptibility, and risk of chronic obstructive pulmonary disease: The UK Biobank Study

Li,

Zhang,

Yang

et al. 2023

Diabetes Obesity Metabolism

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AimTo investigate the effect of metabolic syndrome (MetS), genetic predisposition, and their interactions, on the risk of developing chronic obstructive pulmonary disease (COPD).MethodsCohort analyses included 287 868 participants from the UK Biobank Study. A genetic risk score for COPD was created using 277 single nucleotide polymorphisms. Cox proportional hazard models were used to evaluate the hazard ratios (HRs) with 95% confidence intervals (CIs) for COPD in relation to exposure factors.ResultsDuring 2 658 936 person‐years of follow‐up, 5877 incident cases of COPD were documented. Compared with participants without MetS, those with MetS had a higher risk of COPD (HR 1.24, 95% CI 1.17‐1.32). Compared to participants with low genetic predisposition, those with high genetic predisposition had a 17% increased risk of COPD. In the joint analysis, compared with participants without MetS and low genetic predisposition, the HR for COPD for those with MetS and high genetic predisposition was 1.50 (95% CI 1.36‐1.65; P < 0.001). However, no significant interaction between MetS and genetic risk was found.ConclusionsMetabolic syndrome was found to be associated with an increased risk of COPD, regardless of genetic risk. It is crucial to conduct further randomized control trials to determine whether managing MetS and its individual components can potentially reduce the likelihood of developing COPD.

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 76%

Metabolic syndrome, genetic susceptibility, and risk of chronic obstructive pulmonary disease: The UK Biobank Study

Li,

Zhang,

Yang

et al. 2023

Diabetes Obesity Metabolism

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“…COPD and cardiovascular disease frequently occur together, and the coexistence of these conditions may impact disease risk and prognosis. 57 On differential gene expression analysis between GOLD stages, we also note that genes related to lipoprotein and cholesterol metabolism are higher in the GOLD stage 1 and 2 group compared with the more severe GOLD stage 3 and 4. One of the differentially expressed genes in this network was apolipoprotein E (APOE).…”

mentioning

confidence: 68%

Severity of Lung Function Impairment Drives Transcriptional Phenotypes of COPD and Relates to Immune and Metabolic Processes

Negewo¹,

Gibson²,

Simpson³

et al. 2023

COPD

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This study sought to characterize transcriptional phenotypes of COPD through unsupervised clustering of sputum gene expression profiles, and further investigate mechanisms underlying the characteristics of these clusters. Patients and methods: Induced sputum samples were collected from patients with stable COPD (n = 72) and healthy controls (n = 15). Induced sputum was collected for inflammatory cell counts, and RNA extracted. Transcriptional profiles were generated (Illumina Humanref-8 V2) and analyzed by GeneSpring GX14.9.1. Unsupervised hierarchical clustering and differential gene expression analysis were performed, and gene alterations validated in the ECLIPSE dataset (GSE22148). Results: We identified 2 main clusters (Cluster 1 [n = 35] and Cluster 2 [n = 37]), which further divided into 4 sub-clusters (Subclusters 1.1 [n = 14], 1.2 [n = 21], 2.1 [n = 20] and 2.2 [n = 17]). Compared with Cluster 1, Cluster 2 was associated with significantly lower lung function (p = 0.014), more severe disease (p = 0.009) and breathlessness (p = 0.035), and increased sputum neutrophils (p = 0.031). Sub-cluster 1.1 had significantly higher proportion of people with comorbid cardiovascular disease compared to the other 3 sub-clusters (92.5% vs 57.1%, 50% and 52.9%, p < 0.013). Through supervised analysis we determined that degree of airflow limitation (GOLD stage) was the predominant factor driving gene expression differences in our transcriptional clusters. There were 452 genes (adjusted p < 0.05 and ≥2 fold) altered in GOLD stage 3 and 4 versus 1 and 2, of which 281 (62%) were also found to be significantly expressed between these GOLD stages in the ECLIPSE data set (GSE22148). Differentially expressed genes were largely downregulated in GOLD stages 3 and 4 and connected in 5 networks relating to lipoprotein and cholesterol metabolism; metabolic processes in oxidation/reduction and mitochondrial function; antigen processing and presentation; regulation of complement activation and innate immune responses; and immune and metabolic processes. Conclusion: Severity of lung function drives 2 distinct transcriptional phenotypes of COPD and relates to immune and metabolic processes.

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Physical activity and the risk of chronic obstructive pulmonary disease: A longitudinal follow-up study in Taiwan

Lee,

Huang,

Pan

2024

The American Journal of the Medical Sciences

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Increased Risk of Chronic Obstructive Pulmonary Disease in Patients with Hyperlipidemia: A Nationwide Population-Based Cohort Study

Cited by 4 publications

References 57 publications

Metabolic syndrome, genetic susceptibility, and risk of chronic obstructive pulmonary disease: The UK Biobank Study

Metabolic syndrome, genetic susceptibility, and risk of chronic obstructive pulmonary disease: The UK Biobank Study

Severity of Lung Function Impairment Drives Transcriptional Phenotypes of COPD and Relates to Immune and Metabolic Processes

Physical activity and the risk of chronic obstructive pulmonary disease: A longitudinal follow-up study in Taiwan

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