Increased Risk of Adverse Neurological Development for Late Preterm Infants

Petrini, Joann; Dias, Todd; McCormick, Marie C.; Massolo, Maria L.; Green, Nancy; Escobar, Gabriel J.

doi:10.1016/j.jpeds.2008.08.020

Cited by 382 publications

(229 citation statements)

References 33 publications

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“…Late preterm infants (LPIs) make up nearly 75% of all preterm American births 1 and 20% to 25% of NICU admissions. 2 Compared with full-term infants (FTIs), LPIs are at increased risk for neonatal mortality and morbidity [3][4][5][6][7] and have less proficiency in reading and math at school age, 8 increased rates of cerebral palsy and mental retardation, 9 lower cognitive performance on standardized IQ exams, 10 and more teacher-reported behavior problems. 11 As a result, LPIs have increased need for individualized educational plans and special education services.…”

Section: What This Study Addsmentioning

confidence: 99%

Late Preterm Infants and Neurodevelopmental Outcomes at Kindergarten

et al. 2015

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BACKGROUND AND OBJECTIVE: Late preterm infants (LPIs) (gestation 34 weeks and 0 days to 36 weeks and 6 days) compared with full-term infants (FTIs) are at increased risk for mortality and short-and long-term morbidity. The objective of this study was to assess the neurodevelopmental outcomes in a longitudinal cohort study of LPIs from infancy to school age and determine predictive values of earlier developmental testing compared with school-age testing. METHODS:We used general estimating equations to calculate the odds of school readiness in a nationally representative cohort of 4900 full-term and 950 late preterm infants. We generated positive and negative predictive values of the ability of the 24-month Mental Developmental Index (MDI) scores of the Bayley Short Form, Research Edition, to predict Total School Readiness Score (TSRS) at kindergarten age.RESULTS: In multivariable analysis, late preterm infants had higher odds of worse TSRSs (adjusted odds ratio 1.52 [95% confidence interval 1.06-2.18], P = .0215). The positive predictive value of a child having an MDI of ,70 at 24 months and a TSRS ,5% at kindergarten was 10.4%. The negative predictive value of having an MDI of .70 at 24 months and a TSRS .5% was 96.8%. Most infants improved score ranking over the study interval.CONCLUSIONS: LPIs continue to be delayed at kindergarten compared with FTIs. The predictive validity of having a TSRS in the bottom 5% given a MDI ,70 at 24 months was poor. A child who tested within the normal range (.85) at 24 months had an excellent chance of testing in the normal range at kindergarten. WHAT'S KNOWN ON THIS SUBJECT:Late preterm infants, compared with full-term infants, have less proficiency in reading and math at school age, with increased need for individualized educational plans and special education services. They also have lower cognitive performance on standardized IQ exams.WHAT THIS STUDY ADDS: Late preterm infants have worse outcomes at school entry, and development is variable during the preschool years, so socioeconomic status, language spoken in the home, maternal education, maternal race, and being a late preterm infant have a large impact.

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Section: What This Study Addsmentioning

confidence: 99%

Late Preterm Infants and Neurodevelopmental Outcomes at Kindergarten

et al. 2015

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“…Recently it has been recognized that even late preterm infants, born from 34 to 36 weeks' gestation, are at risk for adverse developmental outcomes. [1][2][3][4][5][6][7][8][9] Less clear, however, is the degree to which developmental risk varies with gestational age among infants born "at term," between 37 and 41 weeks' gestation. Brain development continues throughout gestation, including rapid growth in the final month of pregnancy.…”

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confidence: 99%

“…10,11 Yet children born from 37 to 41 weeks' gestation are frequently combined into a single reference group in studies investigating cognitive outcomes. 1,[3][4][5][6]8,9,[12][13][14] It is unclear whether this cut point of 37 weeks is appropriate, 12 and the degree of heterogeneity in academic achievement across this 5-week period of "normal" gestation remains largely uninvestigated.…”

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Academic Achievement Varies With Gestational Age Among Children Born at Term

Noble

Fifer

Rauh³

et al. 2012

Pediatrics

128

130

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WHAT'S KNOWN ON THIS SUBJECT: Late preterm infants are at risk for a variety of developmental impairments; however, little is known about developmental differences among children born within the term range of 37 to 41 weeks' gestation. WHAT THIS STUDY ADDS:This study links comprehensive birth record data from 128 050 term births to children' s school records 8 years later. Analyses establish that, even among the "normal term" range, gestational age is an important independent predictor of academic achievement.abstract OBJECTIVE: The goal of this study was to examine the degree to which children born within the "normal term" range of 37 to 41 weeks' gestation vary in terms of school achievement.METHODS: This study analyzed data from 128 050 singleton births born between 37 and 41 weeks' gestation in a large US city. Data were extracted from city birth records to assess a number of obstetric, social, and economic variables, at both the individual and community levels. Birth data were then matched with public school records of standardized city-wide third-grade reading and math tests. Specifically, we assessed (1) whether children born within the normal term range of 37 to 41 weeks' gestation show differences in reading and/or math ability 8 years later as a function of gestational age, and (2) the degree to which a wide range of individual-and community-level social and biological factors mediate this effect.RESULTS: Analyses revealed that gestational age within the normal term range was significantly and positively related to reading and math scores in third grade, with achievement scores for children born at 37 and 38 weeks significantly lower than those for children born at 39, 40, or 41 weeks. This effect was independent of birth weight, as well as a number of other obstetric, social, and economic factors. CONCLUSIONS:Earlier normal term birth may be a characteristic considered by researchers, clinicians, and parents to help identify children who may be at risk for poorer school performance. Pediatrics 2012;130:e257-e264 AUTHORS:

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“…Campbell et al 16 demonstrated that the cut-off of -1 SD of TIMP was the one criterion which enables the highest percentile of correct classifications of motor performance at 6 and 12 months of age, 84% and 88% respectively. Kolobeet al 15 .…”

Section: Methodsmentioning

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Factors Related to Motor Developmental Delay of Newborns

Silva

Neves

Frônio

et al. 2014

J. Hum. Growth Dev.

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Artigo baseado em dissertação de mestrado cujos resultados, discussão e resultados serão apresentados em forma de artigos sendo este um deles. Defesa em 2011. Instituição UFJF. INTRODUCTIONSystematic evaluation of motor changes and associated morbidities in neonates in the Neonatal Intensive Care Unit (NICU) may provide important information about neurodevelopmental outcomes 1 and may accelerate the initiation of intervention and facilitate the future development of these children 2 . The number of adverse morbidities in the peri-and neonatal periods increases the risk of delayed developmental changes between 18 and 24 months of corrected age 3 . Studies demonstrate that newborns from the NICU, mainly the extremely preterm newborns, may have delay in their neuromotor and cognitive development due to their biological characteristics (such as gestational age and birth weight) 4,5 or interventions and complications in the peri-and neonatal periods [6][7][8] . Identifying factors which may increase an infant's risk of delay would allow clinicians to focus on children with higher risk and would also allow the enforcement of preventive measures aiming at avoiding the occurrence of such factors.Evaluations of the practices carried out in the maternal and infant units are widely discussed in developed countries. In developing countries, systematic evaluation is just beginning, and data is available through databases such as the Vermont Oxford Network and the Brazilian Net of Neonatal Research 9 .Studies about the relationship between the delay in developmental motor and events observed during the neonatal period usually involve clinical assessments carried out after hospital discharge. In such cases, the links identified might suffer from the interference of factors that took place between discharge from the NICU and the assessment: socioeconomic and stimulation conditions. Assessing the newborns before hospital discharge may prevent these effects.A development evaluation at the time of discharge from the NICU couldbe used by hospital service to evaluate the discharge conditions of its users and to improve services quality, preventing risk factors to motor development delay in newborns. The aim of this study is to verify the . ABSTRACT Introduction: Studies on the association between motor developmental delay and events observed during the neonatal period are performed after discharge. In such cases, the associations found may be interfered by factors occurring between discharge from the NICU and evaluation. Evaluate newborns before hospital discharge can prevent these effects.The purpose of this study is to identify factors related to motor developmental delay of newborns when being discharged from Neonatal Intensive Care Unit. The method chosen to carry out this investigation was a prospective cohort, populationbased and analytic-descriptive study, and 178 newborns were assessed through the Test of Infant Motor Performance. Binomial logistic regression has been developed for analyzing the associated factors. Among th...

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Increased Risk of Adverse Neurological Development for Late Preterm Infants

Cited by 382 publications

References 33 publications

Late Preterm Infants and Neurodevelopmental Outcomes at Kindergarten

Late Preterm Infants and Neurodevelopmental Outcomes at Kindergarten

Academic Achievement Varies With Gestational Age Among Children Born at Term

Factors Related to Motor Developmental Delay of Newborns

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