Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis

Abstract

Individuals with a family history of colorectal cancer have a considerably higher prevalence of adenomas compared to individuals without a family history. This is consistent with their increased risk of colorectal cancer.

Colonoscopy reduced distal colorectal cancer risk and excess cancer risk associated with family history

“…Our results confirm the increased risk of CRCs associated with FHCC in first-degree relatives, although only in women with no colonoscopy screening [25]. Those with previous colonoscopy had a similar risk to those with no FHCC, as already reported [7,30].…”

“…However, analyses stratified on year 2002, which could account for progress in endoscopic techniques, led to similar results in the two periods. New techniques such as virtual chromoendoscopy are being developed to improve detection of flat lesions [25]. In addition, tumors of the proximal colon more often develop from serrated adenomas which often harbor-specific features, such as microsatellite instability, BRAF mutations, or high gene methylation as compared with distal tumors.…”

Prevalence of colonic neoplasia and advanced lesions in the normal population: a prospective population-based colonoscopy study

“…In our study advanced adenomas were found in a minority (2.8%) of the population, predominantly in the age group ‡ 60 years, but these findings are comparable to Lin's study which had a mean age most similar to ours (Table V). It is a well-established fact that increased age is positively correlated with a higher prevalence of adenomas [18], which also was shown in the present study; in those > 60 years old 20% had adenomas compared to 5% in the cohort < 60.…”

Colorectal cancer screening in the familial risk population: Is colonoscopy still the strategy of choice?

“…3 Similarly, a meta-analysis that included 13 studies found an increased risk of colorectal adenomas in individuals with a family history of CRC (OR 1.7; 95% CI 1.4---3.5). 15 Regarding CRC location, FDRs of patients with colon cancer have a higher risk of CRC than those with relatives whose tumors are located in the rectum (RR ≈ 2.3 vs. ≈1.9). FDRs of patients with left-sided colon cancer are at greater risk than those of patients with right-sided tumors.…”