Prevalence of colonic neoplasia and advanced lesions in the normal population: a prospective population-based colonoscopy study

Forsberg, Anna; Kjellström, Lars; Agréus, Lars; Andréasson, Anna; Nyhlin, Henry; Talley, Nicholas J.; Björck, Erik

doi:10.3109/00365521.2011.647062

Cited by 37 publications

(34 citation statements)

References 25 publications

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“…patients improved in as little as 2 weeks, and the effect was sustained for a mean of 33 months. 29 Forsberg et al 30 recently reported prevalence data about colonic lesions in the normal population: one or more polyps were found in 27% of individuals, whereas at least one adenoma was found in 8% of cases, and patients in whom adenoma was found were significantly older than those with a negative CS. On the basis of similar evidence previously published, "European guidelines for quality assurance in colorectal cancer screening and diagnosis" suggest fecal occult blood test for colorectal cancer screening starting from 54 years.…”

Section: Original Research Articlementioning

confidence: 99%

Endoscopic evaluation of gastrointestinal tract in patients with hereditary hemorrhagic telangiectasia and correlation with their genotypes

Canzonieri

Centenara

Ornati

et al. 2014

Genetics in Medicine

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Section: Original Research Articlementioning

confidence: 99%

Endoscopic evaluation of gastrointestinal tract in patients with hereditary hemorrhagic telangiectasia and correlation with their genotypes

Canzonieri

Centenara

Ornati

et al. 2014

Genetics in Medicine

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“…Neoplastic populations of cells and their related clinical states may remain stable and even unchanged for decades (27,28). Indeed, analysis of twins (29) and studies of "normal" individuals (30,31) are providing evidence that undiagnosed (clinically asymptomatic) neoplastic states are more common than previously recognized. It is also important to note that a clone does not have to be obviously enlarged to be categorized as neoplastic, as the extent of growth perturbation may be quite subtle.…”

Section: Introductionmentioning

confidence: 95%

Heterogeneity of Neoplastic Stem Cells: Theoretical, Functional, and Clinical Implications

et al. 2013

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Accumulating evidence suggests that human cancers develop through a step-wise, but nonlinear process of cellular diversification and evolution. Recent mutational analyses indicate that this process is more complex and diverse than anticipated before whole-genome sequencing methods were readily available. Examples are also emerging now of genetically abnormal clones of cells that have acquired mutations with known oncogenic potential but, nevertheless, may show no manifestations of malignant change for many years. To accommodate these diverse realities, we suggest the term neoplastic refer to clones of cells that have any type of somatic aberrancy associated with an increased propensity to become malignant, and the derivative term neoplastic stem cell be adopted to identify the cells responsible for the long-term maintenance of such clones. Neoplastic clones would thus include those that never evolve further, as well as those that eventually give rise to fully malignant populations, and all stages in between. The term cancer stem cells would then be more appropriately restricted to cells generating subclones that have established malignant properties. More precise molecular understanding of the different stem cell states thus distinguished should contribute to the development of more effective prognostic and therapeutic tools for cancer diagnosis and treatment. Cancer Res; 73(3);

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“…17 In light of our results, it seems that individuals with adenomas might have to be followed rigorously with frequent colonoscopies to provide long-term protection from colorectal cancer. In this setting, endoscopic screening seems highly effective.…”

Section: Discussionmentioning

confidence: 82%

Long‐term effectiveness of endoscopic screening on incidence and mortality of colorectal cancer: A randomized trial

et al. 2013

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Background: Due to few randomized trials, there is uncertainty about the long-time effect of endoscopic screening on colorectal cancer (CRC) incidence and mortality. Aim: To evaluate the long-term effect of endoscopic screening on CRC incidence and mortality, we performed a populationbased randomized controlled trial in Norway. Materials and methods: In 1983, 799 Norwegian men and women, age 50-59 years were drawn from the population registry and randomly assigned to flexible sigmoidoscopy screening (400 individuals), or no screening (399 individuals). Colonoscopy surveillance was offered after two and six years for all polyp-bearers in the screening group. In 1996, both groups were offered colonoscopy. Only individuals with advanced adenomas at colonoscopy in 1996 were recommended surveillance. All individuals were followed through Norwegian registries until 2008. Hazard ratios (HR) for CRC incidence, and CRC and overall mortality rates were calculated. Conclusions: This first randomized trial on the long-term effect of endoscopic screening shows reduced CRC incidence and mortality if screening is combined with rigorous surveillance for individuals with polyps. Colonoscopy screening without such surveillance may not be effective.

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Prevalence of colonic neoplasia and advanced lesions in the normal population: a prospective population-based colonoscopy study

Cited by 37 publications

References 25 publications

Endoscopic evaluation of gastrointestinal tract in patients with hereditary hemorrhagic telangiectasia and correlation with their genotypes

Endoscopic evaluation of gastrointestinal tract in patients with hereditary hemorrhagic telangiectasia and correlation with their genotypes

Heterogeneity of Neoplastic Stem Cells: Theoretical, Functional, and Clinical Implications

Long‐term effectiveness of endoscopic screening on incidence and mortality of colorectal cancer: A randomized trial

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