Increased right caudate nucleus size in obsessive-compulsive disorder: Detection with magnetic resonance imaging

Scarone, Silvio; Colombo, Cristina; Livian, Simin; Abbruzzese, Massimo; Ronchi, Paolo; Locatelli, Marco; Scotti, Giuseppe; Smeraldi, Enrico

doi:10.1016/0925-4927(92)90005-o

Cited by 215 publications

(100 citation statements)

References 12 publications

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“…However, the structural magnetic resonance imaging (MRI) findings regarding these regions are inconsistent. Some studies reported increases in volumes [12][13][14] , while some findings indicated decreased volumes [13][14][15][16] . Moreover, some studies even revealed no differences in the volumes of these key brain regions [17][18][19] .…”

Section: Key Brain Regionsmentioning

confidence: 99%

Review of structural neuroimaging in patients with refractory obsessivecompulsive disorder

Atmaca

2011

Neurosci. Bull.

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Abstract:The notion that some special brain regions may be involved in the pathogenesis of obsessive-compulsive disorder (OCD) dates back to the beginning of the twentieth century. Structural neuroimaging studies in the past 2 decades have revealed important findings that facilitate understanding of OCD pathogenesis. Current knowledge based on functional and structural neuroimaging investigations largely emphasizes abnormalities in fronto-striatal-thalamic-cortical and orbitofronto-striato-thalamic circuits in the pathophysiology of OCD. However, these neuroimaging studies did not focus on refractory OCD. The present review mainly focused on structural neuroimaging performed in OCD, which had been ignored previously, and highlighted current evidence supporting that orbito-frontal cortex and thalamus are key brain regions, and that the hippocampus-amygdala complex is associated with refractoriness to the available treatment strategies.However, to fully reveal the neuroanatomy of refractoriness, longitudinal studies with larger samples are required.

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Section: Key Brain Regionsmentioning

confidence: 99%

Review of structural neuroimaging in patients with refractory obsessivecompulsive disorder

Atmaca

2011

Neurosci. Bull.

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“…The intensity of the left-side motor symptoms was associated with cleanliness worries, repetitions, and disturbing thoughts, whereas the severity of right-sided symptoms was significantly related only to obsessions with order and routine. Despite the fact that some neuroimaging studies have shown differences between the two hemispheres 25,26,27,28 , evidence regarding lateralized pathophysiology in OCD is inconclusive as yet.…”

Section: Ocd and Parkinson's Diseasementioning

confidence: 99%

“…In addition to anatomic connections, neuroimaging studies have suggested the participation of the basal ganglia in the pathophysiology of OCD. Several studies using both cranial tomography and magnetic resonance imaging have shown the loss of the asymmetry normally observed in caudate nuclei, the left being larger than the right, in patients with OCD or TS 25,26,27,28 . On the other hand, other authors have shown a reduction in size of the lenticular nucleus (globus pallidus and putamen) in magnetic resonance imaging of patients with TS, however without a change in the caudate volume 46,47 .…”

Section: The Basal Ganglia and The Pathophysiology Of Ocdmentioning

confidence: 99%

Relationship between obsessive-compulsive disorders and diseases affecting primarily the basal ganglia

et al. 1999

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Obsessive-compulsive disorder (OCD) has been reported in association with some neurological diseases that affect the basal ganglia such as Tourette's syndrome, Sydenham's chorea, Parkinson's disease, and Huntington's disease. Furthermore, studies such as neuroimaging, suggest a role of the basal ganglia in the pathophysiology of OCD. The aim of this paper is to describe the association of OCD and several neurologic disorders affecting the basal ganglia, report the existing evidences of the role of the basal ganglia in the pathophysiology of OCD, and analyze the mechanisms probably involved in this pathophysiology.

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“…Despite no consistent results, volumetric abnormalities were detected in basal ganglia in a group of cases (13,14). In single photon emission tomography (SPECT) studies, basal ganglia showed decreased perfusion, whereas bilateral orbitofrontal cortex, left parietal cortex, and bilateral parietal cortex had increased perfusion (15)(16)(17).…”

Section: Discussionmentioning

confidence: 97%

Obsessive compulsive symptoms presented during the course of chronic normal pressure hydrocephalus: a case report

Açar¹,

Ozelci²,

Erol³

2018

Dusunen Adam

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Obsessive compulsive symptoms presented during the course of chronic normal pressure hydrocephalus: a case report Normal pressure hydrocephalus (NPH) is usually presented with psychiatric symptoms. Obsessive compulsive disorder (OCD) and NPH comorbidity is rare and there are only few case reports on this topic.Our case who had chronic NPH secondary to intracranial hemorrhage presented with obsessive compulsive (OC) symptoms while he was treated at neurology inpatient clinic for epilepsy. He benefited from sertraline and quetiapine treatment. Our case is thought to be the first case in terms of comorbidity of chronic NPH and OC symptoms in Turkey.

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Increased right caudate nucleus size in obsessive-compulsive disorder: Detection with magnetic resonance imaging

Cited by 215 publications

References 12 publications

Review of structural neuroimaging in patients with refractory obsessivecompulsive disorder

Review of structural neuroimaging in patients with refractory obsessivecompulsive disorder

Relationship between obsessive-compulsive disorders and diseases affecting primarily the basal ganglia

Obsessive compulsive symptoms presented during the course of chronic normal pressure hydrocephalus: a case report

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