Increased rewarding properties of morphine in perinatally protein-malnourished rats

Valdomero, Analía; Velázquez, Esther; Olmos, Soledad de; Olmos, J.S. de; Orsingher, Otto A.; Cuadra, Gabriel

doi:10.1016/j.neuroscience.2007.09.006

Cited by 18 publications

(14 citation statements)

References 45 publications

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“…These two behaviors were noted in IUGR animals (exaggerated response to cocaine and decreased sucrose preference), suggesting that the IUGR animals may represent an animal model of increased addiction risk as a result of suboptimal prenatal environment. These findings are consistent with other observations in the literature linking malnutrition and addictive behavior in rodents (Palmer et al, 2008; Valdomero et al, 2007; Valdomero et al, 2006; Shultz et al, 1999) and humans (Franzek et al, 2008). …”

Section: Discussionsupporting

confidence: 93%

Early life protein restriction alters dopamine circuitry

et al. 2010

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Adverse prenatal environment, such as intrauterine growth retardation (IUGR), increases the risk for negative neurobehavioral outcomes. IUGR, affecting approximately 10% of all US infants, is a known risk factor for ADHD, schizophrenia spectrum disorders and addiction. Mouse dams were fed a protein deficient (8.5% protein) or isocaloric control (18% protein) diet through pregnancy and lactation (a well validated rodent model of IUGR). Dopamine-related gene expression, dopamine content and behavior were examined in adult offspring. IUGR offspring have 6-8 fold overexpression of dopamine (DA)-related genes (tyrosine hydroxylase (TH) and dopamine transporter) in brain regions related to reward processing (ventral tegmental area (VTA), nucleus accumbens, Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. DISCLOSURE/CONFLICTS OF INTERESTZ Vucetic, K Totoki, H. Schoch, KW Whitaker, T. E. Hill-Smith, and TM Reyes declare no conflicts of interest, either financial or otherwise. Irwin Lucki has been on the Scientific Advisory Board for Wyeth and has received research support from AstraZeneca, Wyeth, Forest and Epix pharmaceutical companies during the past 3 years. NIH Public Access Author ManuscriptNeuroscience. Author manuscript; available in PMC 2011 June 30. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript prefrontal cortex (PFC)) and homeostatic control (hypothalamus), as well as increased number of TH-ir neurons in the VTA and increased dopamine in the PFC. Cyclin-dependent kinase inhibitor 1C (Cdkn1c) is critical for dopaminergic neuron development. Methylation of the promoter region of Cdkn1c was decreased by half and there was a resultant 2-7 fold increase in Cdkn1c mRNA expression across brain regions. IUGR animals demonstrated alterations in dopamine-dependent behaviors, including altered reward-processing, hyperactivity and exaggerated locomotor response to cocaine.These data describe significant dopamine-related molecular and behavioral abnormalities in a mouse model of IUGR. This animal model, with both face validity (behavior) and construct validity (link to IUGR and dopamine dysfunction) may prove useful in identifying underlying mechanisms linking IUGR and adverse neurobehavioral outcomes such as ADHD. Keywordsdopamine; neurodevelopmental programming; epigenetics; addiction; perinatal nutrition A suboptimal prenatal environment, typically indicated by low birth weight or being small for gestational age (SGA), can increase the risk for adverse neurobehavioral outcomes, including ADHD (Hultman et al., 2007;Lahti et al., 2006), schizophr...

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Section: Discussionsupporting

confidence: 93%

Early life protein restriction alters dopamine circuitry

et al. 2010

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“…In the 1990s, it was observed that protein restriction during pregnancy alters reward responses in adulthood (Tonkiss et al, 1990). Some studies have shown that malnutrition leads to an increase in substances that act on the reward system, including opioids, endocannabinoids, and dopamine (Lindblom et al, 2006; Vazquez et al, 2006; Valdomero et al, 2007; Morel et al, 2009). These substances are involved in producing the pleasure sensations produced by the intake of drugs and palatable foods (Solinas and Goldberg, 2005; Mahler et al, 2007), and they coordinate the hedonic control in different ways.…”

Section: Discussionmentioning

confidence: 99%

Perinatal undernutrition stimulates seeking food reward

Silva

Borba

Lira

et al. 2013

Intl J of Devlp Neuroscience

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Experiments in animals have revealed that perinatal nutritional restriction, which manifests in adulthood, increases food intake and preference for palatable foods. Considering this, we aimed to evaluate the effects of perinatal malnutrition on hedonic control of feeding behavior. In this study, we divided Wistar rats into two groups according to the diet provided to their mothers during pregnancy and lactation: the control group (diet with 17% casein) and low-protein group (diet with 8% casein). We assessed the animals' motivational behavior in adulthood by giving them a stimulus of food reward. We also assessed their neuronal activation triggered by the stimulus of palatable food using FOS protein labeling of neurons activated in the caudate putamen, paraventricular, dorsomedial, ventromedial, and lateral hypothalamic nuclei and amygdala. Evaluation of body weight in malnourished animals showed reduction from the 6th day of life until adulthood. Analysis of feeding behavior revealed that these animals were more motivated by food reward, but they had delays during learning of the task. This finding correlated with the number of c-FOS-immunoreactive neurons, which indicated that malnourished animals had an increase in the number of neurons activated in response to the palatable diet, especially in the amygdala and caudate putamen. The study therefore confirmed our hypothesis that early nutritional insults promote changes in encephalic control mechanisms, especially those related to food intake and search for reward.

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“…This is most likely through the improvement of the functional activity of dopamine receptors (Carr et al, 2001) induced by changing dopamine receptor numbers or affinity, or through transduction mechanisms that might be responsible for these changes in manipulated and non-manipulated animals (Silveira et al, 2010). Nevertheless, the exact mechanisms by which the nucleus accumbens develops these functions are not completely understood (Valdomero et al, 2007). More studies are needed to assess and provide solid foundations on the role of dopamine receptors in the motivational aspects of food reward in organisms nutritionally programmed during the perinatal period.…”

Section: Food Intake (Cal/g)x100mentioning

confidence: 99%