Perinatal malnutrition stimulates motivation through reward and enhances drd1a receptor expression in the ventral striatum of adult mice

Martimiano, Paula Honório de Melo; Silva, Gilvanildo Roberto da; Coimbra, Vanessa Fernandes da Silva Almeida; Matos, Rhowena Jane Barbosa de; Souza, Bruno Fernando Pereira de; Silva, Amanda Alves Marcelino da; Melo, Diogo D’Paula Cunha Brasileiro de; Souza, Sandra Lopes de; Freitas, Manuela Figueiroa Lyra de

doi:10.1016/j.pbb.2015.04.008

Cited by 10 publications

(10 citation statements)

References 71 publications

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“…However, exposure to a low-protein diet during gestation (but not caloric restriction per se) is associated with mild hyperphagia in adult females (12 weeks), but not males 12 . Consistent with observations in humans 15,165 , exposure to undernutrition during gestation is associated with an increased preference consumption of high fat foods in male and female rats 13 and increased motivation for palatable food reward in male rats 166,167 and mice 168 . However, preferences for fat are only linked to increased adiposity in females, with no effect on body weight in either gender 13 .…”

Section: Maternal Influences In Rodentssupporting

confidence: 85%

“…Some groups reported increased responsiveness to a palatable food reward in the NAc of adult rats 166,167 , but other groups did not 169,170 . Although several groups reported changes in the expression of key components of the dopamine signaling pathway in the NAc, findings were not consistent across the groups 168–171 .…”

Section: Maternal Influences In Rodentsmentioning

confidence: 86%

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Feeding circuit development and early-life influences on future feeding behaviour

Zeltser

2018

Nat Rev Neurosci

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A wide range of maternal exposures - undernutrition, obesity, diabetes, stress and infection - are associated with an increased risk of metabolic disease in offspring. Developmental influences can cause persistent structural changes in hypothalamic circuits regulating food intake in the service of energy balance. The physiological relevance of these alterations has been called into question because maternal impacts on daily caloric intake do not persist to adulthood. Recent behavioural and epidemiological studies in humans provide evidence that the relative contribution of appetitive traits related to satiety, reward and the emotional aspects of food intake regulation changes across the lifespan. This Opinion article outlines a neurodevelopmental framework to explore the possibility that crosstalk between developing circuits regulating different modalities of food intake shapes future behavioural responses to environmental challenges.

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Section: Maternal Influences In Rodentssupporting

confidence: 85%

Section: Maternal Influences In Rodentsmentioning

confidence: 86%

Feeding circuit development and early-life influences on future feeding behaviour

Zeltser

2018

Nat Rev Neurosci

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“…However, they used a different animal model based on perinatal protein restriction. 52 In this same study there was also a decrease in palatable diet consumption in both the control and malnourished groups after the application of D1 and D2 agonists; however, the anorexic effect of the D1 agonist was understated in malnourished animals.…”

Section: Exploring the Mechanismsmentioning

confidence: 66%

“…However, the increased preference was accompanied by diminished conditioned place preference for this type of food. Interestingly, two studies assessed animals’ motivational behavior in adulthood by giving them a stimulus of food reward and observed that the rats submitted to the perinatal low protein protocol (IUGR) were more motivated by food reward, 51 , 52 and in one of these studies they found that IUGR animals had delays during learning of the task 51 . All these results suggest that IUGR animals are more driven towards food reward and are able to deal with the difficulty to find the food, even though they have learning and/or association difficulties.…”

Section: Experimental Evidencementioning

confidence: 99%

The fetal programming of food preferences: current clinical and experimental evidence

Molle

Bischoff

Portella

et al. 2015

J Dev Orig Health Dis

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Increased energy consumption is one of the major factors implicated in the epidemic of obesity. There is compelling evidence, both clinical and experimental, that fetal paucity of nutrients may have programming effects on feeding preferences and behaviors that can contribute to the development of diseases. Clinical studies in different age groups show that individuals born small for their gestational age (SGA) have preferences towards highly caloric foods such as carbohydrates and fats. Some studies have also shown altered eating behaviors in SGA children. Despite an apparent discrepancy in different age groups, all studies seem to converge to an increased intake of palatable foods in SGA individuals. Small nutrient imbalances across lifespan increase the risk of noncommunicable diseases in adult life. Homeostatic factors such as altered responses to leptin and insulin and alterations in neuropeptides associated with appetite and satiety are likely involved. Imbalances between homeostatic and hedonic signaling are another proposed mechanism, with the mesocorticolimbic dopaminergic pathway having differential reward and pleasure responses when facing palatable foods. Early exposure to undernutrition also programs hypothalamic-pituitary-adrenal axis, with SGA having higher levels of cortisol in different ages, leading to chronic hyperactivity of this neuroendocrine axis. This review summarizes the clinical and experimental evidence related to fetal programming of feeding preferences by SGA.

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“…Additionally, we found that overall, the 'health-conscious' maternal dietary pattern was inversely associated with 'enjoyment of food' in boys but not in girls, and positively associated with 'slowness in eating' at 6 months of age. Several animal studies have examined the effect of maternal diet on feeding behaviour 31,32 and neurobiological processes [33][34][35] controlling appetite in the offspring. However, to the best of our knowledge, this is the first study to assess the effect of third-trimester diet in women with GDM on a questionnaire-based assessment, i.e., the 36 .…”

Section: Discussionmentioning

confidence: 99%

The relationship between maternal dietary patterns during pregnancy in women with gestational diabetes mellitus and infant appetitive feeding behaviour at 6 months

Amissah

Gamble

Wall

et al. 2020

Sci Rep

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Early dietary exposure may influence infant appetitive feeding behaviour, and therefore their later health. Maternal diabetes in pregnancy is associated with an increased risk of obesity in the offspring. We, therefore, examined third-trimester dietary patterns of women with gestational diabetes, their offspring’s appetitive feeding behaviour at 6 months of age, and relationships between these. We used data from a prospective cohort of women with gestational diabetes and assessed maternal dietary patterns at 36 weeks’ gestation using principal component analysis; infant appetitive feeding behaviour at 6 months of age using the Baby Eating Behaviour Questionnaire; and relationships between these using general linear modelling and chi-square tests. In 325 mother-infant dyads, we identified three distinct maternal dietary patterns: ‘Junk,’ ‘Mixed,’ and ‘Health-conscious.’ The maternal ‘Health-conscious’ pattern was inversely associated with ‘enjoyment of food’ in their sons (β − 0.24, 95% CI − 0.36 to − 0.11, p = 0.0003), but not daughters (β − 0.02, 95% CI − 0.12 to 0.08, p = 0.70), and was positively associated with ‘slowness in eating,’ (β 0.13, 95% CI 0.02 to 0.24, p = 0.01). Third-trimester dietary patterns in women with gestational diabetes may have sex-specific effects on infant appetitive feeding behaviour at 6 months of age.

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Perinatal malnutrition stimulates motivation through reward and enhances drd1a receptor expression in the ventral striatum of adult mice

Abstract: Perinatal protein malnutrition stimulates hedonic control of eating behavior by promoting increased intake of palatable foods, possibly due to increased expression of dopamine receptor DRD1a in the ventral striatum.

Cited by 10 publications

References 71 publications

Feeding circuit development and early-life influences on future feeding behaviour

Feeding circuit development and early-life influences on future feeding behaviour

The fetal programming of food preferences: current clinical and experimental evidence

The relationship between maternal dietary patterns during pregnancy in women with gestational diabetes mellitus and infant appetitive feeding behaviour at 6 months

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