Increased Respiratory Burst and Increased Expression of Complement Receptor-3 (CD11b/CD18) and of IL-8 Receptor-A in Neutrophil Granulocytes from Newborns after Vaginal Delivery

Gessler, Peter; Dahinden, Clemens A.

doi:10.1159/000067962

Cited by 33 publications

(27 citation statements)

References 24 publications

(24 reference statements)

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“…Although there have been some studies regarding the effect of mode of delivery on the newborn immune system; these studies have not evaluated the mothers [1,[7][8][9][10]. A recent study appeared in Pubmed evaluating Treg cells in newborns and their mothers together but mode of delivery was not considered in this study [19].With the increasing prevalence of C-section deliveries, it is expected that the findings of the current study will provide some additional information for benefit to the health of newborns and mothers as well as contribute to basic research needed in this area.…”

Section: Discussionmentioning

confidence: 99%

“…There have been some studies that have investigated effects of the mode of delivery on neonatal T-cell phenotype and function [12], on circulating cytokine concentrations in the perinatal period [13], on gut microbiotal composition (a secondary aim of that study) [14], on phagocyte functions of infants for the first 6 months of life [15], on respiratory burst and expression of complement receptor-3 (CD11b/CD18) and IL-8 receptor-A in neutrophil granulocytes [7],on leukocyte counts during the first 5 days of life [8] and on interferon-gamma and interleukin-12 production by cord blood mononuclear cells [10]. All of these studies suggest that mode of delivery affects the immune system of newborns but none of them evaluated effects on the immune system of the mother.…”

Section: Discussionmentioning

confidence: 99%

“…However, in some regions of Turkey [6] it can be as high as 40%. Adverse effects of the mode of delivery on the neonatal immune system have been reported previously [7][8][9][10][11][12][13][14][15], but the relationship between mode of delivery and Treg cells has not been studied. Therefore, the purpose of this study was to evaluate whether the mode of delivery (normal versus Csection) has an influence the CD4+CD25+FOXP3+ Treg cells in newborn cord blood and maternal peripheral blood.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Mode of Delivery on T Regulatory (Treg) Cells of Cord Blood

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effect of Mode of Delivery on T Regulatory (Treg) Cells of Cord Blood

et al. 2011

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“…In addition, the use of whole blood samples avoids artifactual changes in function induced by purification procedures (25). To eliminate the influence of stress factors such as labor (26,27) or infection and to assess the maturation of the phagocyte immune response, we investigated neutrophils and monocytes obtained from human fetuses by percutaneous intrauterine umbilical vein sampling and compared it with cord blood from healthy neonates as well as peripheral blood from adults. We are aware that the fetuses were eligible for research investigations only because cord blood sampling was indicated for medical reasons, i.e.…”

Section: Discussionmentioning

confidence: 99%

Differential Maturation of the Innate Immune Response in Human Fetuses

et al. 2004

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Newborns and especially preterm infants show a unique susceptibility to severe bacterial infections that cause significant morbidity and mortality. As very few data are available on innate immune functions in human fetuses, we conducted a comprehensive study to investigate the expression of several adhesion molecules essentially involved in migration (CD11a, CD11b, CD11c, CD18, and CD62L). Furthermore, phagocytic activity, generation of respiratory burst products, and production of several proinflammatory cytokines were assessed. Various functions of the fetal innate immune system were demonstrated to be essentially different from those observed in term neonates or adults. Expression of several surface markers was significantly diminished on fetal granulocytes. Furthermore, a significantly reduced phagocytic activity of fetal granulocytes and monocytes was found, contrasted by an enhanced generation of reactive oxygen products. In addition, we demonstrate that significant numbers of fetal monocytes are capable of the production of proinflammatory cytokines in response to stimulation. However, the pattern of cytokine production is different from the more mature individuals: the number of IL-6 -and tumor necrosis factor-␣-positive monocytes were significantly diminished, whereas more IL-8 -producing monocytes were found compared with adults. The results of our study add significantly to our understanding of the maturation and impairment of the innate immune response. Neonates, especially preterm infants, are prone to severe and overwhelming bacterial infection with substantial morbidity and mortality. Despite intensive supportive care and early use of antibiotics, the rate of morbidity and mortality caused by infections remains high (1). Although multiple factors contribute to this susceptibility, the immaturity of the innate immune system, especially production of phagocytes and several phagocyte functions (e.g. chemotaxis, phagocytosis, respiratory burst, cytokine production) are of paramount importance (2,3). Evidence of this is provided by the pattern of infections closely resembling that seen in profound neutropenia (4). Depleted neutrophil storage pools and neutropenia were described to be associated with neonatal sepsis and are negative predictors of outcome (5,6). Several qualitative deficiencies of phagocyte function were demonstrated earlier in preterm infants and stressed or septic neonates. The functional deficiencies comprised migration, phagocytosis, and bactericidal potency, for example, release of bactericidal/permeabilityincreasing protein (7-15). However, normal or even enhanced spontaneous neutrophil respiratory burst activity in term and preterm neonates was reported in other studies (16,17). In contrast, little is known to date about the phagocytic and oxidative capacity as well as the adhesion molecule expression of fetal neutrophils and monocytes. The expression of several adhesion molecules essentially involved in migration was reported to be significantly impaired in neonates and to contri...

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“…Levels of interleukin-8 (IL-8) and TNF-␣ are known to increase in the maternal circulation during labor, and these inflammatory mediators have been reported to activate neutrophils and suppress apoptosis (4,5). Increases in maternal blood levels of the complement component C3b, CD11b/CD18 adhesion molecules, and IL-8 receptors are also observed during labor, and these may contribute to decreased neutrophil apoptosis (6). Hypoxia, which can occur transiently during labor, also suppresses neutrophil apoptosis (7)(8)(9).…”

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confidence: 99%