Increased renin release during renal arteriolar dilatation in dogs

Gotshall, RW; Davis, JO; Blaine, E H; Musacchia, X. J.; Braverman, Berton; Freeman, R. H.; Johnson, Julian

doi:10.1152/ajplegacy.1974.227.2.251

Cited by 27 publications

(13 citation statements)

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“…With partial aortic constriction, however, the effects of these inhibitors on renal hemodynamics and APR were readily apparent, not surprisingly since this maneuver leads to prompt stimulation and renal release of endogenous PG and All (21)(22)(23)(24)(25)(26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

“…As with fluid movement across extrarenal capillary beds, rates of filtration and absorption of fluid across renal glomerular and peritubular capillaries are governed by local imbalances in transcapillary hydraulic and colloid osmotic pressures (the so-called Starling forces) (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) (21)(22)(23)(24)(25)(26)(27)(28); both hormone systems are capable of altering glomerular and postglomerular Starling forces substantially (18)(19)(20)(29)(30)(31)(32)(33)(34). The present study was therefore designed to evaluate the roles played by these endoge-I)ous renal vasoactive substances in mediating the close coupling betweeni CFR and APR that occurs in response to partial aortic constriction in the Munich-Wistar rat.…”

Section: Introductionmentioning

confidence: 99%

“…Receive(d for publicationi 22 October 1979 and in revised formrl 3 Januiary 1980. 1192 for APR duiring redtuced RAP in grouip 2 thaln in grotup 1 is also attriblutablle to this pronouniiced( rise in RE, the effect of wlhich was to autigmiienit the net realbsorptive pressture both by favori ng higher p)ostglomiiertular oncotic pressture alild lower downstreamn (peritubular capillary) hydrauilic presstlre. Since intratrenial release of' All is enhanllce( wvhen RAP (leclinies, and because All is knowni to raise RE selectively, it is likely that endogenous All brought about the marked increase in RE in grouip 2, which was readily demnonstrable only in indomethacin-treated rats, presumably because endogenouis PG synthesis wvas stippressed.…”

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confidence: 99%

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Importance of Efferent Arteriolar Vascular Tone in Regulation of Proximal Tubule Fluid Reabsorption and Glomerulotubular Balance in the Rat

Ichikawa¹,

Brenner²

1980

J. Clin. Invest.

102

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A B S T R A C T Micropunctre study was performed in 21 mildly volumne-expanded Mlunich-Wistar rats before and during partial aortic constriction to examine the effects of endogenious prostaglandins (PG) and angiotenisin II (All) on single nephron glomerular filtration rate (SNGFR) and al)solute proximal reabsorption rate (APR). Animilals received either vehicle (group 1), indomethacini (group 2), or indomethacin plus saralasin (group 3). Before aortic constriction, these inhibitors were without effect on values of SNGFR and APR. In grouip 1 rats, reduction in mean renal arterial perfusion pressture (RAP) to -65 mm Hg resulted in m-arked and prop)ortional declines in SNGFR and APR. With equivalent re(duiction in RAP in grouip 2 rats, however, SNGFR fell to a lesser extent and APR tended to increase slightly above preconstriction values. Indomethacin admiiinistration was therefore associated with disruption of' glomerulotubular balance. In view of the roughly e(lllivalent dleclines in afferent arteriolar resistance measture(d in grouips 1 aind( 2, the milagnittude of increase in efferen1t arteriolar resistaince (RE) appeared to be of imiajor importance in determiiining the observed presence or ahsence of glomeruilottubuilar balance. Thus, the lesser filtl in SNGFR in grouip 2 thain in grouip 1 was a resuilt of' the higher value for glomeruilar capillarv hydrauilic pressture in grouip 2, a conseqtuence of the higlher value of RE. The higher average value Portions of' these stuidies were presented at the Eastern Section

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Importance of Efferent Arteriolar Vascular Tone in Regulation of Proximal Tubule Fluid Reabsorption and Glomerulotubular Balance in the Rat

Ichikawa¹,

Brenner²

1980

J. Clin. Invest.

102

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“…One of its characteristics is the low blood pressure in renal arterioles [Bucciet al, 1972;Richer et al, 1977]. Numerous data about intrarenal baroreceptor mechanism in the control of the synthesis and secretion of renin are in favor of this interpretation [Blaine et al, 1970;Blaine and Davis, 1971;Gotchal et al, 1974;Sadowska and Wocial, 1977].…”

Section: Discussionmentioning

confidence: 99%

Postnatal development of the kidney juxtaglomerular apparatus in rats

Lačković¹,

Mujović²

1980

Cells Tissues Organs

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The development of the juxtaglomerular (JG) apparatus in the rat kidney was investigated at different times of postnatal life (1, 2, 3, 5, 7, 10, 15, 30 and 60 days). On the 1st day after birth, secretory granules were found in JG cells in preglomerular arterioles of juxtamedular nephrons and in interlobular arteries. JG indices are high at this stage and decrease until the 5th day, then gradually rise until the 60th day. The possible reasons for such findings are discussed. Macula densa cells start to differ as early as the 1st day after birth. They are very distinct already at 2 days and they reach typical organization by the 15th day. Extraglomerular mesangial cells are few in early postnatal life. Their number increases later on. The parallelism between nephrogenesis and development is discussed.

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“…The tubuloglomerular feedback theory states that alterations in perfusion pressure alter glomerular filtration and thereby alter tubular flow and/or compo sition. This results in a signal being transmit ted through the macula densa to the pregiomerular vascular smooth muscle to appro priately adjust vascular resistance [3][4][5], Tubuloglomerular feedback can be elimi nated in kidneys without glomerular filtra tion and tubular flow, thus leaving intact any myogenic mechanism. In a previous study [5] investigating renal renin release, it was noted that kidneys without glomerular filtration (nonfiltering kidneys) exhibited blood flow autoregulation.…”

Section: Introductionmentioning

confidence: 99%

Efficiency of Canine Renal Blood Flow Autoregulation in Kidneys with or without Glomerular Filtration

Gotshall¹,

Heß²,

Mills³

1985

J Vasc Res

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In order to evaluate vascular (myogenic) and tubular (tubuloglomerular feedback) mechanisms involved in renal blood flow (RBF) autoregulation, canine kidneys with filtration (normal) and without filtration (nonfiltering, NFK; ureteral-obstructed, UO) were studied. RBF was monitored in response to stepwise reductions in renal perfusion pressure of –20, –40, and –60 mm Hg from control pressure. None of the three groups demonstrated significant changes in RBF from their respective control values (normal, 380 ml/min/100 g; NFK, 179 ml/min/100 g; UO, 153 ml/min/100 g) until the lowest pressure (–60 mm Hg from control pressure). All three groups responded to the pressure reductions with significant decreases in renal vascular resistance. However, the calculated efficiency of the autoregulatory response for the NFK and UO groups was significantly less than for the normal group. Elimination of tubuloglomerular feedback (NFK and UO) did not necessarily eliminate renal vascular autoregulation, but did reduce the efficiency of autoregulation. It is suggested that both vascular (myogenic) and tubular (tubuloglomerular) mechanisms may coexist to efficiently autoregulate blood flow in normal filtering kidneys. However, a reduction in metabolic activity as a contributor to the reduced ability to autoregulate in these kidneys could be an additional possibility.

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Increased renin release during renal arteriolar dilatation in dogs

Cited by 27 publications

References 0 publications

Importance of Efferent Arteriolar Vascular Tone in Regulation of Proximal Tubule Fluid Reabsorption and Glomerulotubular Balance in the Rat

Importance of Efferent Arteriolar Vascular Tone in Regulation of Proximal Tubule Fluid Reabsorption and Glomerulotubular Balance in the Rat

Postnatal development of the kidney juxtaglomerular apparatus in rats

Efficiency of Canine Renal Blood Flow Autoregulation in Kidneys with or without Glomerular Filtration

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