Importance of Efferent Arteriolar Vascular Tone in Regulation of Proximal Tubule Fluid Reabsorption and Glomerulotubular Balance in the Rat

Ichikawa, Iekuni; Brenner, Barry M.

doi:10.1172/jci109774

Cited by 102 publications

(50 citation statements)

References 43 publications

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“…The vasoconstrictor effect of Ang II on efferent arterioles causes changes in peritubular capillary dynamics that could increase renal tubular fluid reabsorption (33). The efferent arteriolar vasoconstriction would reduce the peritubular capillary hydrostatic pressure as well as increase peritubular capillary colloid osmotic pressure due to an increase in the filtration fraction.…”

Section: Renal Actions Of Angiotensin IImentioning

confidence: 99%

Renal actions of angiotensin-(1-7)

Silva¹,

Baracho²,

Passaglio³

et al. 1997

Braz J Med Biol Res

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The heptapeptide angiotensin-(1-7) is considered to be a biologically active endproduct of the renin-angiotensin system. This angiotensin, which is devoid of the most known actions of angiotensin II such as induction of drinking behavior and vasoconstriction, has several selective effects in the brain and periphery. In the present article we briefly review recent evidence for a physiological role of angiotensin-(1-7) in the control of hydroelectrolyte balance.

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Section: Renal Actions Of Angiotensin IImentioning

confidence: 99%

Renal actions of angiotensin-(1-7)

Silva¹,

Baracho²,

Passaglio³

et al. 1997

Braz J Med Biol Res

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“…In the brain, intraventricular injection of angiotensin II causes a dramatic pressor response mediated by AT 1 receptors (14). In the kidney, activation of AT 1 receptors is associated with renal vasoconstriction and antinatriuresis (15,16). Furthermore, it has been suggested that activation of AT 1 receptors at the juxtaglomerular apparatus suppresses renin release through the so-called short-loop feedback mechanism (17,18).…”

Section: Introductionmentioning

confidence: 99%

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system

Crowley¹,

Gurley²,

Oliverio³

et al. 2005

J. Clin. Invest.

275

115

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Angiotensin II, acting through type 1 angiotensin (AT 1 ) receptors, has potent effects that alter renal excretory mechanisms. Control of sodium excretion by the kidney has been suggested to be the critical mechanism for blood pressure regulation by the renin-angiotensin system (RAS). However, since AT 1 receptors are ubiquitously expressed, precisely dissecting their physiological actions in individual tissue compartments including the kidney with conventional pharmacological or gene targeting experiments has been difficult. Here, we used a cross-transplantation strategy and AT 1A receptor-deficient mice to demonstrate distinct and virtually equivalent contributions of AT 1 receptor actions in the kidney and in extrarenal tissues to determining the level of blood pressure. We demonstrate that regulation of blood pressure by extrarenal AT 1A receptors cannot be explained by altered aldosterone generation, which suggests that AT 1 receptor actions in systemic tissues such as the vascular and/or the central nervous systems make nonredundant contributions to blood pressure regulation. We also show that interruption of the AT 1 receptor-mediated short-loop feedback in the kidney is not sufficient to explain the marked stimulation of renin production induced by global AT 1 receptor deficiency or by receptor blockade. Instead, the renin response seems to be primarily determined by renal baroreceptor mechanisms triggered by reduced blood pressure. Thus, the regulation of blood pressure by the RAS is mediated by AT 1 receptors both within and outside the kidney.

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“…Previous investigators have shown under a variety of experimental conditions that changes in absolute proximal fluid reabsorption rate (APR) occur in a manner predictable from simultaneously measured levels of peritubular intracapillary oncotic and hydraulic forces (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Thus, reduction in the concentration of postglomerular plasma protein, induced by a variety of experimental maneuvers, such as intravenous infusion of large volume of colloid-free solutions, was associated with a decrease in APR (4,8).…”

Section: Introductionmentioning

confidence: 99%

Blood flow dependence of postglomerular fluid transfer and glomerulotubular balance.

Kon¹,

Hughes²,

Ichikawa³

1983

J. Clin. Invest.

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A B S T R A C T The rate of blood flow entering a capillary network can, in some vascular systems, regulate capillary surface area and the rate of fluid and solute transfer. To determine whether such a mechanism exists in the renal peritubular capillary, we performed micropuncture studies in 28 rats during relatively low and high efferent arteriolar blood flow (EABF). High EABF was achieved by intravenous infusion of isoncotic plasma (group 1: from 120±11 to 301±49 nl/min [±SE]); whole blood with high hematocrit (-75 vol %) (group 2: from 141±14 to 252±31 nl/min); or acetylcholine (group 3: from 193±20 to 266±26 nl/min). In group 1 rats, plasma infusion caused an increase in single nephron glomerular filtration rate (SNGFR), on average, from 23.2±2.4 to 45.2±3.9 nl/min, owing primarily to increased glomerular plasma flow rate (from 63±5 to 210±21 nl/min). The rate of fluid uptake by the peritubular capillary, assessed by the absolute rate of proximal fluid reabsorption (APR), also rose significantly, on average from 10.5±1.2 to 17.5±2.4 nl/min. This rise in APR was associated with near constancy in mean transcapillary hydraulic (AP() and oncotic (AlIc) pressure differences, and was therefore at-

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Importance of Efferent Arteriolar Vascular Tone in Regulation of Proximal Tubule Fluid Reabsorption and Glomerulotubular Balance in the Rat

Cited by 102 publications

References 43 publications

Renal actions of angiotensin-(1-7)

Renal actions of angiotensin-(1-7)

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system

Blood flow dependence of postglomerular fluid transfer and glomerulotubular balance.

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