“…Several roles have been proposed for this gland such as water homeostasis [27,28], neuronal survival [29], detoxification [30], monoamines clearance in the CSF [31], lordosis [32], in the pathophysiology of hydrocephalus [33] and possibly of hepatic encephalopathy [34]. Previous works have shown that the SCO receives several neuronal innervations of GABAergic [35,36], noradrenergic and dopaminergic [27] and serotonergic nature [28,34,37]. The latter is the most influential system upon the secretory activity of the SCO in different mammalian species [34,[38][39][40][41].…”