Differential regional responsiveness of astroglia in mild hepatic encephalopathy: An Immunohistochemical approach in bile duct ligated rat

Hiba, Omar El; Elgot, Abdeljalil; Ahboucha, Samir; Gamrani, Halima

doi:10.1016/j.acthis.2016.03.003

Cited by 16 publications

(10 citation statements)

References 51 publications

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“…Astrocytic swelling and brain edema induced by ammonia and accumulation of osmotic glutamine could be the outcome of the downregulation of the genes coding for cytoskeletal network components implicated in glial cell volume regulation. 53,60 GFAP, a key marker of mature astroglia, is a filament cytoskeleton protein responsible for astrocyte structural and mechanical stability. 5,61 In the present work, the HE group showed a significant reduction in GFAP protein expression in the cerebral cortex, hippocampus, and striatum (Fig.…”

Section: Food and Function Papermentioning

confidence: 99%

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Thymol ameliorated neurotoxicity and cognitive deterioration in a thioacetamide-induced hepatic encephalopathy rat model; involvement of the BDNF/CREB signaling pathway

et al. 2022

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Section: Food and Function Papermentioning

confidence: 99%

“…These findings are in harmony with previous reports. 60,62 This reduction of GFAP protein could be the result of the destabilization of GFAP mRNA in hyperammonemic conditions. 63 Reduced GFAP could partly explain the observed cytotoxic cell swelling and brain edema in the HE group.…”

Section: Food and Function Papermentioning

confidence: 99%

Thymol ameliorated neurotoxicity and cognitive deterioration in a thioacetamide-induced hepatic encephalopathy rat model; involvement of the BDNF/CREB signaling pathway

et al. 2022

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“…4,11,21,23,52,66 Histological studies of BDL rat brains are controversial, some reporting no change, increased or decreased of GFAP staining in different brain regions. 26,68,69 Regarding AQP4, a recent study showed reduced expression in the olfactory bulb and prefrontal cortex in BDL rats. 50 Thus, additional studies in BDL rats would be useful to further our understanding of the changes/ mechanisms/factors implicated in this animal model.…”

Section: Early Neurometabolic Events In Cldmentioning

confidence: 99%

Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy

Braissant

Račkayová

Pierzchała

et al. 2019

Journal of Hepatology

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In hepatic encephalopathy, early neurometabolic changes occur 2-4 weeks post-bile-duct ligation. In hepatic encephalopathy, brain glutamine increases, but creatine and ascorbate decrease. Changes in astrocyte morphology are observed 4 weeks after bile-duct ligation. Early changes in hepatic encephalopathy are suggestive of osmotic/oxidative stress. Early changes in hepatic encephalopathy are accentuated 6-8 weeks after bile-duct ligation.

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“…This suggests that BDL-induced osmotic stress and increased AQP4 may contribute to morphological changes in astrocytes, something recently shown in adult BDL rats 18 . The pathophysiology and functional implications of the observed changes in astrocyte morphology are still incompletely understood, given that these changes have also been shown in hyperammonemic rats without CLD and may differ according to brain region [37][38][39][40] . Although the neurometabolism of rats having undergone BDL at day 21 differs from that of adults, our data suggest that the morphological changes are rather similar 18 .…”

Section: Neurometabolic Response To Plasma Ammonium Liver Disease Ismentioning

confidence: 99%

Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease

Račkayová

Braissant

Rougemont

et al. 2020

Sci Rep

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type c hepatic encephalopathy (type c He) is increasingly suspected in children with chronic liver disease (CLD), and believed to underlie long-term neurocognitive difficulties. The molecular underpinnings of type c He in both adults and children are incompletely understood. in the present study we combined the experimental advantages of in vivo high field 1 H magnetic resonance spectroscopy with immunohistochemistry to follow longitudinally over 8 weeks the neurometabolic changes in the hippocampus of animals having undergone bile duct ligation as pups. Rats who develop cLD early in life displayed pronounced neurometabolic changes in the hippocampus characterized by a progressive increase in glutamine concentration which correlated with plasma ammonia levels and a rapid decrease in brain myo-inositol. Other neurometabolic findings included a decrease in other organic osmolytes (taurine, choline-containing compounds and creatine), ascorbate and glutamate. At the cellular level, we observed an increase in glial fibrillary acidic protein (GFAP) and aquaporin 4 (AQP4) expression in the hippocampus at 4 weeks post bile duct ligation (BDL), together with astrocytic morphological alterations. These findings differ from observations in the brain of adult rats following BDL, and are in keeping with the commonly accepted theory of age-dependent vulnerability.

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Differential regional responsiveness of astroglia in mild hepatic encephalopathy: An Immunohistochemical approach in bile duct ligated rat

Cited by 16 publications

References 51 publications

Thymol ameliorated neurotoxicity and cognitive deterioration in a thioacetamide-induced hepatic encephalopathy rat model; involvement of the BDNF/CREB signaling pathway

Thymol ameliorated neurotoxicity and cognitive deterioration in a thioacetamide-induced hepatic encephalopathy rat model; involvement of the BDNF/CREB signaling pathway

Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy

Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease

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