“…4,11,21,23,52,66 Histological studies of BDL rat brains are controversial, some reporting no change, increased or decreased of GFAP staining in different brain regions. 26,68,69 Regarding AQP4, a recent study showed reduced expression in the olfactory bulb and prefrontal cortex in BDL rats. 50 Thus, additional studies in BDL rats would be useful to further our understanding of the changes/ mechanisms/factors implicated in this animal model.…”