Thymol ameliorated neurotoxicity and cognitive deterioration in a thioacetamide-induced hepatic encephalopathy rat model; involvement of the BDNF/CREB signaling pathway

Ogaly, Hanan A.; Abdel-Rahman, Rehab F.; Mohamed, Magda S.; Farid, Omar; Khattab, Marwa S.; Abd‐Elsalam, Reham M.

doi:10.1039/d1fo04292k

Cited by 28 publications

(32 citation statements)

References 79 publications

(130 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thymol (2-isopropyl-5-methylphenol) is a natural monoterpenoid phenol found in high concentrations in the oils of thyme from different Thymus species such as T. vulgaris , T. spicata , and T. ciliates and Nigella sativa seeds [ 126 ]. Several pharmacological activities of thymol have been defined, such as fungicidal, antibiotic, and anti-inflammatory activities.…”

Section: Resultsmentioning

confidence: 99%

Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis

Liaqat

Parveen

Kim

2022

IJMS

View full text Add to dashboard Cite

Modern neurological approaches enable detailed studies on the pathophysiology and treatment of depression. An imbalance in the microbiota–gut–brain axis contributes to the pathogenesis of depression. This extensive review aimed to elucidate the antidepressive effects of brain-derived neurotrophic factor (BDNF)-targeting therapeutic natural products and their derivatives on the gut–brain axis. This information could facilitate the development of novel antidepressant drugs. BDNF is crucial for neuronal genesis, growth, differentiation, survival, plasticity, and synaptic transmission. Signaling via BDNF and its receptor tropomyosin receptor kinase B (TrkB) plays a vital role in the etiopathogenesis of depression and the therapeutic mechanism of antidepressants. This comprehensive review provides information to researchers and scientists for the identification of novel therapeutic approaches for neuropsychiatric disorders, especially depression and stress. Future research should aim to determine the possible causative role of BDNF-TrkB in the gut–brain axis in depression, which will require further animal and clinical research as well as the development of analytical approaches.

show abstract

Section: Resultsmentioning

confidence: 99%

Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis

Liaqat

Parveen

Kim

2022

IJMS

View full text Add to dashboard Cite

show abstract

“…The seeds of T. ammi (commonly called ajwain), an aromatic plant with thymol as its principal component (39.1%), are used for medicinal and culinary purposes (Singh et al, 2004). TASE and thymol have been reported to exhibit neuroprotective potentials (Ogaly et al, 2022; Soni & Parle, 2017). However, the molecular insights into the neuroprotective and neurogenic potential of TASE and thymol are not well understood.…”

Section: Discussionmentioning

confidence: 99%

“…Trachyspermum ammi is an aromatic plant rich in essential oils such as thymol, terpinene, p‐cymene, and pinenes (Singh et al, 2004). T. ammi seed extract (TASE) and its principal component thymol are reported with neuroprotective potentials (Ogaly et al, 2022; Soni & Parle, 2017). However, molecular insights learning, memory, and adult neurogenesis potential are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Thymol inTrachyspermum ammiseed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine‐induced Alzheimer's disease mouse model

Timalsina

Haque

Choi

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

Several reports have stated the neuroprotective and learning/memory effects of Tachyspermum ammi seed extract (TASE) and its principal component thymol; however, little is known about its underlying molecular mechanisms and neurogenesis potential. This study aimed to provide insights into TASE and a thymolmediated multifactorial therapeutic approach in a scopolamine-induced Alzheimer's disease (AD) mouse model. TASE and thymol supplementation significantly reduced oxidative stress markers such as brain glutathione, hydrogen peroxide, and malondialdehyde in mouse whole brain homogenates. Tumor necrosis factor-alpha was significantly downregulated, whereas the elevation of brain-derived neurotrophic factor and phospho-glycogen synthase kinase-3 beta (serine 9) enhanced learning and memory in the TASE-and thymol-treated groups. A significant reduction in the accumulation of Aβ 1-42 peptides was observed in the brains of TASE-and thymol-treated mice. Furthermore, TASE and thymol significantly promoted adult neurogenesis, with increased doublecortin positive neurons in the subgranular and polymorphic zones of the dentate gyrus in treated-mice. Collectively, TASE and thymol could potentially act as natural therapeutic agents for the treatment of neurodegenerative disorders, such as AD.

show abstract

“…( 19 ). The tissue sections of knee joints of different experimental groups were deparaffinized in xylene and rehydrated in alcohol, then the antigenic retrieval was performed using citrate buffer at pH 6.0 as described by ( 20 ) Ogaly et al ( 20 ) . Rabbit anti-TGF-β1 polyclonal antibody (ab92486; Abcam, Cambridge, UK) at 20 µg/mL and rabbit anti-caspase-3 polyclonal antibody (ab13847; Abcam, Cambridge, UK) at 1:50 were added to the tissue section then placed in a humidified chamber for overnight.…”

Section: Methodsmentioning

confidence: 99%

Crataegus sinaica defatted methanolic extract ameliorated monosodium iodoacetate-induced oxidative stress andinhibited inflammation in a rat model of osteoarthritis

et al. 2022

View full text Add to dashboard Cite

Background and purpose: Osteoarthritis is a degenerative joint disease without definite treatment. It is characterized by intra-articular inflammation, cartilage degeneration, subchondral bone remodeling, and joint pain. The objective of the current study was to assess the anti-osteoarthritic effect and the possible underlying mechanism of action of Crataegus sinaica extract (CSE). Experimental approach: Intra-articular injection of monosodium iodoacetate in the right knee joint of all rats was done except for the sham group. One week later, the anti-inflammatory efficacy of CSE (100, 200, 300 mg/kg, daily p.o) for 4 successive weeks versus ibuprofen (40 mg/kg, p.o) was assessed. Serum inflammatory cytokines; as well as weekly assessment of knee joint swelling, joint mobility, and motor coordination were done. At the end of the experiment, a histopathological investigation of the affected knee joints and an x-ray investigation were also executed. Findings / Results: CSE significantly decreased joint swelling, pain behaviors, and serum levels of TNF-α, IL6, hyaluronic acid, and CTX-II. The radiographic findings revealed almost normal joint space with normal radiodensity and diameter in CSE-treated rats. As well, the histopathological and immunohistochemical investigations of the knee joints in CSE-treated groups retained the cartilage structure of knee joints. A significant reduction in the percentage of caspase-3-stained chondrocytes and a decrease in TGF-β1 immuno-positive areas in the synovial lining and sub lining were recorded in CSE-treated rats, compared to the osteoarthritis control group. Conclusion and implications: This study approved the chondroprotective effects of CSE, and its ability to inhibit the pain associated with osteoarthritis.

show abstract

Thymol ameliorated neurotoxicity and cognitive deterioration in a thioacetamide-induced hepatic encephalopathy rat model; involvement of the BDNF/CREB signaling pathway

Abstract: In the present study, we aimed to delineate the neuroprotective potential of thymol (THY) against neurotoxicity and cognitive deterioration induced by thioacetamide (TAA) in an experimental model of hepatic encephalopathy...

Cited by 28 publications

References 79 publications

Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis

Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis

Thymol inTrachyspermum ammiseed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine‐induced Alzheimer's disease mouse model

Crataegus sinaica defatted methanolic extract ameliorated monosodium iodoacetate-induced oxidative stress andinhibited inflammation in a rat model of osteoarthritis

Contact Info

Product

Resources

About