Increased Pyrethroid Resistance in Malaria Vectors and Decreased Bed Net Effectiveness, Burkina Faso

Toé, Hyacinthe K.; Jones, Christopher M.; Sagnon, N’Falé; Ismail, Hanafy M.; Dabiré, Roch K.; Ranson, Hilary

doi:10.3201/eid2010.140619

Cited by 209 publications

(202 citation statements)

References 12 publications

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“…coluzzii are sympatric within the region, with the latter being predominant in the rice field habitats. Local malaria vectors exhibits high levels of resistance to pyrethroids and DDT454647. In particular a high frequency of the L1014 kdr mutation is observed in An .…”

Section: Methodsmentioning

confidence: 99%

Larval nutritional stress affects vector life history traits and human malaria transmission

Vantaux

Lefèvre

Cohuet

et al. 2016

Sci Rep

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Exposure to stress during an insect’s larval development can have carry-over effects on adult life history traits and susceptibility to pathogens. We investigated the effects of larval nutritional stress for the first time using field mosquito vectors and malaria parasites. In contrast to previous studies, we show that larval nutritional stress may affect human to mosquito transmission antagonistically: nutritionally deprived larvae showed lower parasite prevalence for only one gametocyte carrier; they also had lower fecundity. However, they had greater survival rates that were even higher when infected. When combining these opposing effects into epidemiological models, we show that larval nutritional stress induced a decrease in malaria transmission at low mosquito densities and an increase in transmission at high mosquito densities, whereas transmission by mosquitoes from well-fed larvae was stable. Our work underscores the importance of including environmental stressors towards understanding host–parasite dynamics to improve disease transmission models and control.

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Section: Methodsmentioning

confidence: 99%

Larval nutritional stress affects vector life history traits and human malaria transmission

Vantaux

Lefèvre

Cohuet

et al. 2016

Sci Rep

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“…These resistant mosquitoes can survive up to 1000 times the concentration of insecticide that kills susceptible mosquitoes, and investigators are increasingly noting blood-fed mosquitoes inside longlasting insecticide-treated bednets or resting on newly sprayed walls. 12–15 …”

Section: Current Situationmentioning

confidence: 99%

Averting a malaria disaster: will insecticide resistance derail malaria control?

et al. 2016

Self Cite

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World Malaria Day 2015 highlighted the progress made in the development of new methods of prevention (vaccines and insecticides) and treatment (single dose drugs) of the disease. However, increasing drug and insecticide resistance threatens the successes made with existing methods. Insecticide resistance has decreased the efficacy of the most commonly used insecticide class of pyrethroids. This decreased efficacy has increased mosquito survival, which is a prelude to rising incidence of malaria and fatalities. Despite intensive research efforts, new insecticides will not reach the market for at least 5 years. Elimination of malaria is not possible without effective mosquito control. Therefore, to combat the threat of resistance, key stakeholders need to rapidly embrace a multifaceted approach including a reduction in the cost of bringing new resistance management methods to market and the streamlining of associated development, policy, and implementation pathways to counter this looming public health catastrophe.

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“…5,6 Recent reports confirming the rapid spread of insecticide resistance underline the need for alternative approaches in addition to insecticide-based methods. [7][8][9][10][11][12] In this study, we aimed to quantify the effects of eave screening in combination with a push-pull system that interferes with mosquito host-seeking behavior through the simultaneous release of repellent volatiles from the house eaves to "push" mosquitoes away from the peridomestic space and attractive volatiles released from an odor-baited trap to "pull" mosquitoes toward this alternative, pseudohost and remove them from the environment. Push-pull is a term originally adopted in the context of agricultural pest management.…”

Section: Introductionmentioning

confidence: 99%

Eave Screening and Push-Pull Tactics to Reduce House Entry by Vectors of Malaria

Menger¹,

Omusula²,

Wouters³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Long-lasting insecticidal nets and indoor residual spraying have contributed to a decline in malaria over the last decade, but progress is threatened by the development of physiological and behavioral resistance of mosquitoes against insecticides. Acknowledging the need for alternative vector control tools, we quantified the effects of eave screening in combination with a push-pull system based on the simultaneous use of a repellent (push) and attractant-baited traps (pull). Field experiments in western Kenya showed that eave screening, whether used in combination with an attractant-baited trap or not, was highly effective in reducing house entry by malaria mosquitoes. The magnitude of the effect varied for different mosquito species and between two experiments, but the reduction in house entry was always considerable (between 61% and 99%). The use of outdoor, attractant-baited traps alone did not have a significant impact on mosquito house entry but the high number of mosquitoes trapped outdoors indicates that attractant-baited traps could be used for removal trapping, which would enhance outdoor as well as indoor protection against mosquito bites. As eave screening was effective by itself, addition of a repellent was of limited value. Nevertheless, repellents may play a role in reducing outdoor malaria transmission in the peridomestic area.

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Increased Pyrethroid Resistance in Malaria Vectors and Decreased Bed Net Effectiveness, Burkina Faso

Abstract: This new resistance will have serious effects on malaria control.

Cited by 209 publications

References 12 publications

Larval nutritional stress affects vector life history traits and human malaria transmission

Larval nutritional stress affects vector life history traits and human malaria transmission

Averting a malaria disaster: will insecticide resistance derail malaria control?

Eave Screening and Push-Pull Tactics to Reduce House Entry by Vectors of Malaria

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