Larval nutritional stress affects vector life history traits and human malaria transmission

Vantaux, Amélie; Lefèvre, Thierry; Cohuet, Anna; Dabiré, Kounbobr Roch; Roche, Benjamín; Roux, Olivier

doi:10.1038/srep36778

Cited by 50 publications

(51 citation statements)

References 60 publications

(96 reference statements)

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“…Further, nutrient availability and daily temperature regimes can vary significantly among active breeding containers distributed in the same household area (Hemme et al, 2009). Despite shared genetic ancestry, larval stress has proven a critical influence on adult phenotype, which in turn is strikingly correlated with a suite of life history traits including vector competence (De Jesus and Reiskind, 2016; Honek, 1993; Mourya et al, 2004; Ponlawat and Harrington, 2007; Price et al, 2015; Schluter et al, 1991; Vantaux et al, 2016). In a previous study, our laboratory demonstrated the G × E influence of larval stress on adult body size (Schneider et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Larval stress alters dengue virus susceptibility in Aedes aegypti (L.) adult females

et al. 2017

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In addition to genetic history, environmental conditions during larval stages are critical to the development, success and phenotypic fate of the Aedes aegypti mosquito. In particular, previous studies have shown a strong genotype-by-environment component to adult mosquito body size in response to optimal vs stressed larval conditions. Here, we expand upon those results by investigating the effects of larval-stage crowding and nutritional limitation on the susceptibility of a recent field isolate of Aedes aegypti to dengue virus serotype-2. Interestingly, female mosquitoes from larvae subjected to a stressed regime exhibited significantly reduced susceptibility to disseminated dengue infection 14 days post infection compared to those subjected to optimal regimes. Short term survivorship post-infected blood feeding was not significantly different. As with body size, dengue virus susceptibility of a mosquito population is determined by a combination of genetic and environmental factors and is likely maintained by balancing selection. Here, we provide evidence that under different environmental conditions, the innate immune response of field-reared mosquitoes exhibits a large range of phenotypic variability with regard to dengue virus susceptibility. Further, as with body size, our results suggest that mosquitoes reared under optimal laboratory conditions, as employed in all mosquito-pathogen studies to date, may not always be realistic proxies for natural populations.

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Section: Introductionmentioning

confidence: 99%

Larval stress alters dengue virus susceptibility in Aedes aegypti (L.) adult females

et al. 2017

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“…Then, infectious humans remain infectious (Ih) during a period equals to 1/ on average. See parameter values in table supplement S1 (Roux et al 2015, Vantaux et al 2016. In our simulation we based the HBI of exposed mosquitoes ( s) on the confidence intervals of oocyst-infected mosquitoes that were experimentally measured in this study.…”

Section: Mathematical Modelmentioning

confidence: 99%

Field evidence for manipulation of mosquito host selection by the human malaria parasite, Plasmodium falciparum

Vantaux

Yao

Hien

et al. 2017

Preprint

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Whether the malaria parasite Plasmodium falciparum can manipulate mosquito host choice in ways that enhance parasite transmission toward humans is unknown. We assessed the influence of P. falciparum on the blood-feeding behaviour of three of its major vectors (Anopheles coluzzii, An. gambiae and An. arabiensis) in Burkina Faso. Host preference assays using odour-baited traps revealed no effect of infection on mosquito long-range anthropophily. However, the identification of the blood meal origin of mosquitoes showed that females carrying sporozoites, the mature transmissible stage of the parasite, displayed a 24% increase in anthropophagy compared to both females harbouring oocysts, the parasite immature stage, and uninfected individuals. Using a mathematical model, we further showed that this increased anthropophagy in infectious females resulted in a > 250% increase in parasite transmission potential, everything else being equal. This important epidemiological consequence highlights the importance of vector control tools targeting infectious females.

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“…It is an important factor regarding host-pathogen interactions; as host nutrition influences multiple measures of adult performance, immune response, and the resources necessary for pathogen replication (Lee et al 2006, 2008; Telang et al 2012, Yee et al 2015). Larval nutritional stress can reduce the immune response of mosquitoes allowing for increased pathogen infection (Sindbis virus; Muturi et al 2011) or reduce resources for pathogen development (malaria; Vantaux et al 2016ab). Further, nutritionally stressed larvae result in adults with reduced mass.…”

Section: Introductionmentioning

confidence: 99%

Linking nutrient stoichiometry to Zika virus transmission in a mosquito

Paige

Bellamy

Alto

et al. 2019

Preprint

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Food quality and quantity serve as the basis for cycling of key chemical elements in trophic interactions, yet the role of nutrient stoichiometry in shaping host-parasite interactions is under appreciated. Most of the emergent mosquito-borne viruses affecting human health are transmitted by mosquitoes that inhabit container systems during their immature stages, where allochthonous input of detritus serves as the basal nutrients. Quantity and type of detritus (animal and plant) were manipulated in microcosms containing newly hatched Aedes aegypti mosquito larvae. Adult mosquitoes derived from these microcosms were allowed to ingest Zika virus infected blood and then tested for disseminated infection, transmission, and total nutrients (percent carbon, percent nitrogen, ratio of carbon to nitrogen). Treatments lacking high quality animal (insect) detritus significantly delayed development. Survivorship to adulthood was closely associated with the amount of insect detritus present. Insect detritus was positively correlated with percent nitrogen, which affected Zika virus infection. Disseminated infection and transmission decreased with increasing insect detritus and percent nitrogen. We provide the first definitive evidence linking nutrient stoichiometry to arbovirus infection and transmission in a mosquito using a model system of invasive Ae. aegypti and emergent Zika virus.

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Larval nutritional stress affects vector life history traits and human malaria transmission

Cited by 50 publications

References 60 publications

Larval stress alters dengue virus susceptibility in Aedes aegypti (L.) adult females

Larval stress alters dengue virus susceptibility in Aedes aegypti (L.) adult females

Field evidence for manipulation of mosquito host selection by the human malaria parasite, Plasmodium falciparum

Linking nutrient stoichiometry to Zika virus transmission in a mosquito

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