Increased pulse wave velocity and relationship with inflammation, insulin, and insulin resistance in inflammatory bowel disease

Abstract

This study showed increased PWV, homocysteine, erythrocyte sedimentation rate, C-reactive protein, insulin, and homeostasis model assessment of insulin resistance in patients with active and inactive IBD and provides evidence of the potential contribution of inflammation and inflammation-related factors toward arterial stiffening independent from conventional cardiovascular risk factors.

Pulse wave velocity differs between ulcerative colitis and chronic kidney disease

“…The association between disease duration, a variable associated with chronic inflammation, and increased arterial stiffness in patients with UC is in accordance with previous data [11,12,28,29]; the association between acute inflammation and arterial stiffening has been previously reported in other models of inflammation [30]. Taken together, these findings suggest that, in contrast to physiological aging and accelerated aging reported in patients with CKD, in whom aortic, but not brachial stiffening was shown, in UC patients both elastic and muscular components of arterial tree could be affected by inflammation.…”

Arterial stiffness in inflammatory bowel disease

“…The cf-PWV was significantly increased in patients with IBD in eight studies [18][19][20][21][22][24][25][26] and slightly but not significantly increased in patients with IBD in one study ( Table 2) [23]. Moreover, in the second article published by our group in 2014 [21], it was also reported the results of a small prospective study showing a reduction of aortic stiffening after 3 years of follow-up in seven patients with IBD treated with anti-TNFa therapy.…”

“…In total, 7092 articles were excluded according to a review of the title and the abstract only. The remaining 10 crosssectional studies, published within the last 5 years, reported PWV measurements for the IBD patients and their respective control patients [17][18][19][20][21][22][23][24][25][26]. One of these studies, which included 42 patients with IBD (Crohn's disease 60%) and 73 control patients, measured ab-PWV [17]; the main results of this study are reported in Tables 1 and 2.…”

“…One of these studies, which included 42 patients with IBD (Crohn's disease 60%) and 73 control patients, measured ab-PWV [17]; the main results of this study are reported in Tables 1 and 2. The remaining nine studies, which included 234 patients with Crohn's disease, 342 patients with ulcerative colitis, and 435 control patients, measured cf-PWV and were included in the metaanalysis [18][19][20][21][22][23][24][25][26]. The main results of these studies and the devices and techniques used to measure the cf-PWV are reported in Tables 1 and 2.…”

“…The main results of these studies and the devices and techniques used to measure the cf-PWV are reported in Tables 1 and 2. Furthermore, eight of the nine studies included in the meta-analysis reported the use of anti-TNFa therapy and were included in the metaregression analysis [18][19][20][21][22][23][24]26] ( Table 2).…”