Arterial stiffness in inflammatory bowel disease

Zanoli, Luca; Rastelli, Stefania; Basile, Antonio; Inserra, G.; Empana, Jean‐Philippe; Boutouyrie, Pierre; Laurent, Stéphane; Castellino, Pietro

doi:10.1097/hjh.0000000000000867

Cited by 43 publications

(30 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We did not establish any difference in arterial stiffness parameters between IBD subgroups, which is consistent with the meta-analysis by Zanoli et al and pilot research on the pediatric IBD population [9,62]. Furthermore, there was no difference in CST and arterial stiffness between different groups according to the anti-TNF-α therapy in the present study.…”

Section: Discussionsupporting

confidence: 90%

“…Arterial stiffness is a well-established predictor of the cardiovascular mortality and morbidity [42]. Findings of increased arterial stiffness in IBD patients compared to healthy subjects are consistent with most previous studies [9,52]. A pioneer study in 2012 on IBD patients showed increased arterial stiffness in comparison to healthy subjects [53].…”

Section: Discussionsupporting

confidence: 82%

“…A pioneer study in 2012 on IBD patients showed increased arterial stiffness in comparison to healthy subjects [53]. Importantly, meta-analysis by Zanoli et al confirmed significantly increased carotid-femoral PWV in IBD patients [9]. Consequently, IBD patients in the present study had significantly higher prevalence of end-organ damage detected by PWV > 10 m/s.…”

Section: Discussionsupporting

confidence: 56%

“…In addition, an independent positive correlation exists between CST and PWV which could emphasize the relationship between IBD, CST and increased arterial stiffness. However, the role of CST in the pathophysiology of IBD and a complex link between IBD and increased cardiovascular risk have not been well-established [9,14,43].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the adverse inflammatory effect on arteries was further confirmed with a recent systematic review by Zanoli et al, that reported a significant increase in pulse wave velocity (PWV), a golden standard for estimation of arterial stiffness, in patients with IBD. Increased arterial stiffness likely presents the initiation and/or progression of atherogenesis and arterial hypertension [9].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Serum Catestatin Levels and Arterial Stiffness Parameters Are Increased in Patients with Inflammatory Bowel Disease

Živković

Matetić

Hadjina

et al. 2020

JCM

View full text Add to dashboard Cite

Catestatin (CST) is an important peptide in the pathophysiology of chronic inflammatory disorders. However, clinical studies on inflammatory bowel disease (IBD) patients are lacking. Our goal was to investigate CST concentrations in IBD patients compared to healthy subjects. Additionally, we aimed to determine arterial stiffness parameters in relation to CST. This cross-sectional study compared 80 IBD patients (45 Crohn’s disease (CD) and 35 ulcerative colitis (UC) patients) with 75 control subjects. Serum CST levels were significantly higher in the IBD group compared to control subjects (11.29 ± 9.14 vs. 7.13 ± 6.08 ng/mL, p = 0.001) and in the UC group compared to CD patients (13.50 ± 9.58 vs. 9.03 ± 6.92 ng/mL, p = 0.021), irrespective of age and BMI. IBD patients exhibited significantly higher values of heart rate adjusted central augmentation index (cAIx-75) (14.88 ± 10.59 vs. 6.87 ± 9.50 %, p < 0.001) and pulse wave velocity (PWV) (8.06 ± 3.23 vs. 6.42 ± 1.47 m/s, p < 0.001) compared to control group. Furthermore, PWV was the only significant independent correlate of CST (B = 1.20, t = 4.15, p < 0.001), while CST, PWV, cAIx-75, high-sensitivity C-reactive protein and BMI were significant predictors of positive IBD status (1.089 (1.022–1.161), 1.515 (1.166–1.968), 1.060 (1.024–1.097), 1.458 (1.116–1.906), 0.793 (0.683–0.920), respectively). Serum CST levels were significantly higher in IBD patients compared to controls and an independent positive correlation of CST with PWV existed. Therefore, it is possible that CST could have a role in the complex pathophysiology of IBD and its cardiovascular complications.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Serum Catestatin Levels and Arterial Stiffness Parameters Are Increased in Patients with Inflammatory Bowel Disease

Živković

Matetić

Hadjina

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

Arterial structure and function in children with inflammatory bowel disease

Jois,

Zannino,

Catto‐Smith

et al. 2024

JGH Open

View full text Add to dashboard Cite

Background and AimPeople with inflammatory bowel disease (IBD) have an increased risk of cardiovascular disease, including in younger adulthood. This may arise in part from chronic, systemic low‐grade inflammation. The process of atherosclerosis may begin in childhood. We sought to determine whether pediatric IBD is associated with adverse changes in arterial structure and function as a marker of early increased cardiovascular risk.MethodsWe performed a case–control study comparing children with IBD for a median disease duration of 2.49 (interquartile range 1.23, 4.38) years with healthy children. In a single visit, we collected baseline clinical and anthropometric data, and measured blood pressure, pulse wave velocity, carotid artery distensibility, and aortic and carotid intima‐media thickness. High‐sensitivity C‐reactive protein and fasting lipids were measured.ResultsWe enrolled 81 children with IBD (40 with Crohn's disease, 40 with ulcerative colitis, and 1 with unspecified IBD) and 82 control participants. After adjusting for age, sex, body mass index z‐score, blood pressure, and low‐density lipoprotein cholesterol, there was no difference in measures of arterial structure and function in children with IBD compared with controls, nor between those with Crohn's disease or ulcerative colitis.ConclusionWe did not show any differences in arterial structure and function in children with a history of IBD for less than 5 years compared with healthy controls. IBD diagnosed in childhood may provide a window of opportunity to actively reduce standard cardiovascular risk factors and improve future cardiovascular outcomes.

show abstract

Arterial Stiffness in Early Phases of Prehypertension

Laurent

Cunha

2018

Updates in Hypertension and Cardiovascular Protection

View full text Add to dashboard Cite

Children, adolescent, and adults with prehypertension have a high risk for developing hypertension. Modifiable cardiovascular risk factors, such as prediabetes and diabetes mellitus, overweight and obesity, high lipid diet, high salt intake, and lack of regular physical activity play a crucial role in the transition between prehypertension and hypertension. Because these cardiovascular risk factors are key determinants of increased arterial stiffness, and because increased arterial stiffness is a determinant of incident hypertension, the question arises as to whether arterial stiffness plays a crucial role in the transition between early phases of prehypertension and hypertension. In this review, we will analyze the epidemiological and hemodynamic evidences that increased arterial stiffness is a determinant of incident hypertension. We will also address the complexity of this relationship by discussing the hemodynamic and biomechanical pathways involved in the bidirectional influence between arterial stiffness and blood pressure. And then, we will discuss (a) the predictive value of arterial stiffness not only for incident hypertension, but also for cardiovascular events, (b) the influence of low-grade inflammation associated with chronic diseases in the development of arterial stiffness and subsequently hypertension, (c) how the concept of Early Vascular Ageing can help understanding the relationship between arterial stiffness and prehypertension, and (d) the relationships between metabolic syndrome, arterial stiffness, and prehypertension in children.

show abstract

Arterial stiffness in inflammatory bowel disease

Abstract: cf-PWV is increased in both ulcerative colitis and Crohn's disease patients.

Cited by 43 publications

References 38 publications

Serum Catestatin Levels and Arterial Stiffness Parameters Are Increased in Patients with Inflammatory Bowel Disease

Serum Catestatin Levels and Arterial Stiffness Parameters Are Increased in Patients with Inflammatory Bowel Disease

Arterial structure and function in children with inflammatory bowel disease

Arterial Stiffness in Early Phases of Prehypertension

Contact Info

Product

Resources

About