Increased prolyl endopeptidase activity in human neoplasia

Larrinaga, Gorka; Perez, Itxaro; Blanco, Lorena; López, José I.; Andrés, Leire; Etxezarraga, Carmen; Santaolalla, Francisco; Zabala, Aitor; Varona, Amparo; Irazusta, Jon

doi:10.1016/j.regpep.2010.03.012

Cited by 33 publications

(43 citation statements)

References 51 publications

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“…When benign tumors were compared with corresponding healthy tissues, the difference was not particularly high (approximately 15%), but the difference between malignant tumors and healthy tissues was marked (approximately 27%). Similar findings have been made when measuring PREP enzyme activities (Goossens et al 1996;Larrinaga et al 2010) and for PREP coding mRNA (GeneSapiens; Kilpinen et al 2008). Interestingly, in the study of Larrinaga et al (2010), there was no difference in a PREP activity between colon adenocarcinoma and normal mucosa.…”

Section: Discussionsupporting

confidence: 77%

“…Similar findings have been made when measuring PREP enzyme activities (Goossens et al 1996;Larrinaga et al 2010) and for PREP coding mRNA (GeneSapiens; Kilpinen et al 2008). Interestingly, in the study of Larrinaga et al (2010), there was no difference in a PREP activity between colon adenocarcinoma and normal mucosa. However, we saw a 26% increase in PREP OD, suggesting increased PREP protein levels in these tumor samples.…”

Section: Discussionsupporting

confidence: 77%

“…However, epithelial cells showed high PREP mRNA (the above databases), protein (this study), and enzyme activity levels (Goossens et al 1996). Moreover, in tumors, PREP protein amounts, enzyme activities (Goossens et al 1996;Larrinaga et al 2010), and PREP mRNA (GeneSapiens; Kilpinen et al 2008) were uniformly increased.…”

Section: Discussionmentioning

confidence: 57%

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Distribution of Prolyl Oligopeptidase in Human Peripheral Tissues and in Ovarian and Colorectal Tumors

Myöhänen

Pyykkö

Männistö

et al. 2012

J Histochem Cytochem.

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SummaryProlyl oligopeptidase (PREP) is a serine protease that hydrolyzes peptides shorter than 30-mer, and it has been connected with multiple physiological and pathological conditions. PREP has been mostly studied in the brain, but significant PREP activities have been measured in peripheral tissues. Moreover, increased PREP activities have been found in tumors. In this study, the authors studied the immunohistochemical distribution of PREP protein in human peripheral tissues and in ovarian and colorectal tumors. PREP was found to be widely distributed in human peripheral tissues and specifically in certain cells. The most intense PREP expression was seen in the testis, ovaries, liver, and some parts of the skin. At the cellular level, high PREP levels were seen as a rule in secreting epithelial cells and cells involved in reproduction. Increased PREP expression was seen in most of the tumors studied. PREP expression was higher in malignant than benign tumors, and in ovarian epithelial cancers, there was a trend for increased PREP staining with increased malignancy grade. Results suggest that PREP may be associated with secretory processes as well as in reproduction. A more abundant expression of PREP in malignant than benign tumors suggests that PREP may be associated with expansion and metastasis of tumors. (J Histochem Cytochem 60:706-715, 2012)

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 77%

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Distribution of Prolyl Oligopeptidase in Human Peripheral Tissues and in Ovarian and Colorectal Tumors

Myöhänen

Pyykkö

Männistö

et al. 2012

J Histochem Cytochem.

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“…Thus, POP inhibition can represent an important supporting approach in AD treatment, and, therefore, the search for new compounds influencing more therapeutic targets connected with AD is required. colorectal adenomatous polyp suggest that this enzyme could be involved also in these malignancies [24].…”

Section: Resultsmentioning

confidence: 99%

Isoquinoline alkaloids as prolyl oligopeptidase inhibitors

et al. 2015

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“…Altered patterns of the expression and catalytic function of PEP may contribute to several different disease processes [22,23], though it is not yet known to what extent, as there is a lack of data on the level of activity and expression of PEP in adenotonsillar inflammatory disease. Consequently, it is difficult to interpret these results.…”

Section: Discussionmentioning

confidence: 99%