Increased prolidase activity and oxidative stress in <scp>PCOS</scp>

Hilali, Neşe Gül; Vural, Mehmet; Camuzcuoğlu, Hakan; Camuzcuoğlu, Aysun; Aksoy, Nurten

doi:10.1111/cen.12110

Cited by 68 publications

(39 citation statements)

References 27 publications

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“…Prolidase is a matrix metalloproteinase (MMP) that degrades the extracellular matrix. It was found that increased MMPs can result in symptoms seen in women with PCOS such as abnormal ovarian extracellular remodeling, multiple cyst formation, and chronic anovulation, leading to infertility [37]. …”

Section: Oxidative Stress and Female Fertilitymentioning

confidence: 99%

“…The ECM is the microenvironment around cells that provides them with physical support. It is also responsible for transmitting signals for the different cellular functions [37]. Matrix metalloproteinases (MMP) are extracellular peptidases that hydrolyze several proteins including those making up the ECM and therefore could contribute to the altered cellular environment and various pathologies [104].…”

Section: Role Of Proteomics In Polycystic Ovarian Syndrome (Pcos)mentioning

confidence: 99%

“…Hilali et al studied the amount of prolidase expressed in PCOS patients in an attempt to assess the association of MMP with the disease. The results showed that prolidase was increased in the serum of PCOS patients in comparison to normal women in addition to the increase in oxidative stress levels [37]. Multiple studies reported increased prolidase activity in patients with cardiovascular disease [106].…”

Section: Role Of Proteomics In Polycystic Ovarian Syndrome (Pcos)mentioning

confidence: 99%

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Power of Proteomics in Linking Oxidative Stress and Female Infertility

Gupta

Ghulmiyyah

Sharma

et al. 2014

BioMed Research International

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Endometriosis, PCOS, and unexplained infertility are currently the most common diseases rendering large numbers of women infertile worldwide. Oxidative stress, due to its deleterious effects on proteins and nucleic acids, is postulated to be the one of the important mechanistic pathways in differential expression of proteins and in these diseases. The emerging field of proteomics has allowed identification of proteins involved in cell cycle, as antioxidants, extracellular matrix (ECM), cytoskeleton, and their linkage to oxidative stress in female infertility related diseases. The aim of this paper is to assess the association of oxidative stress and protein expression in the reproductive microenvironments such as endometrial fluid, peritoneal fluid, and follicular fluid, as well as reproductive tissues and serum. The review also highlights the literature that proposes the use of the fertility related proteins as potential biomarkers for noninvasive and early diagnosis of the aforementioned diseases rather than utilizing the more invasive methods used currently. The review will highlight the power of proteomic profiles identified in infertility related disease conditions and their linkage with underlying oxidative stress. The power of proteomics will be reviewed with regard to eliciting molecular mechanisms for early detection and management of these infertility related conditions.

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Section: Oxidative Stress and Female Fertilitymentioning

confidence: 99%

Section: Role Of Proteomics In Polycystic Ovarian Syndrome (Pcos)mentioning

confidence: 99%

Section: Role Of Proteomics In Polycystic Ovarian Syndrome (Pcos)mentioning

confidence: 99%

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Power of Proteomics in Linking Oxidative Stress and Female Infertility

Gupta

Ghulmiyyah

Sharma

et al. 2014

BioMed Research International

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“…Still, AA patients have not been studied concerning their prolidase activity. Hilali et al [11] determined an increased serum enzyme activity of prolidase and increased oxidative stress in polycystic ovary syndrome. Bozkurt et al [13] examined serum prolidase levels and oxidative stress parameters in patients with Behçet’s disease.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Paraoxonase, Arylesterase, Prolidase Activities and Oxidative Stress in Patients with Alopecia Areata

Dizen-Namdar

Koçak

Kıdır³

et al. 2018

Skin Pharmacol Physiol

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Background: Alopecia areata (AA) is a disease characterized by the hair loss sharply limited in any part of the body, especially on the scalp, in circular or oval areas. The purpose of this study is to search the serum paraoxonase 1 (PON1), arylesterase and oxidative status with serum prolidase activities in people with AA. Methods: The study included 60 AA and 50 healthy control subjects. In both groups, serum PON1, prolidase, arylesterase activities, total oxidative status (TOS) and total antioxidant capacity (TAS) levels and oxidative stress index (OSI) were calculated. Results: TOS, OSI levels and prolidase activity in patients with AA were found to be significantly higher compared to the control group (p = 0.02, p = 0.004, p < 0.001, respectively), whereas PON1 and arylesterase activities were significantly lower (p < 0.001, p = 0.005, respectively). There was no difference in serum TAS levels between the two groups. Conclusion: This comprehensive work shows that the role of oxidative stress is very important in the pathogenesis of AA. In this study, we believe that we clarified the pathogenesis of oxidative stress for AA patients by investigating the TAS, TOS, OSI levels, PON1, arylesterase and prolidase enzyme activity parameters.

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“…It has been known that women with PCOS have increased cardiovascular risk. It might be hypothesized that elevated serum prolidase activity and oxidative stress might be associated with an increased cardiovascular risk in that patients (42).…”

Section: Oxidative Stress and Prolidasementioning

confidence: 99%

Prolidase

Namiduru¹

2016

BLL

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Prolidase (EC.3.4.13.9) or proline dipeptidase, is one of the unique enzyme capable of degrading dipeptides, in which a proline or hydroxyproline residue is located at the C-terminal position. Prolidase has a unique function in all cell types; therefore, the mechanisms and parameters involved in prolidase activity regulation are of special interest. Could prolidase be a good biomarker in different physiologic and pathologic conditions? This is an important question. There is no consensus on the answer to this question. It is of great importance during collagen turnover, infl ammation, tissue fi brosis and skeletal abnormalities. Prolidase itself without other biochemical markers may not provide information to clinicians about disease activity. So, I think it should be evaluated together with other serum biochemical markers. This review will serve to discuss many in vivo functions of prolidase, as well as level prolidase activity in diagnosis and monitoring of treatment in the various diseases (Ref. 50). Text in PDF www.elis.sk.

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Increased prolidase activity and oxidative stress in PCOS

Abstract: Women with PCOS have increased serum prolidase activity and oxidative stress. It might be hypothesized that elevated serum prolidase activity and oxidative stress may be associated with increased cardiovascular risk in PCOS and/or menstrual irregularities associated with this syndrome.

Cited by 68 publications

References 27 publications

Power of Proteomics in Linking Oxidative Stress and Female Infertility

Power of Proteomics in Linking Oxidative Stress and Female Infertility

Evaluation of Serum Paraoxonase, Arylesterase, Prolidase Activities and Oxidative Stress in Patients with Alopecia Areata

Prolidase

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