Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease

ÖBerg, Bengt; McMenamin, Elizabeth; Lucas, F. Lee; McMonagle, Ellen; Morrow, Jason D.; İkizler, T. Alp; Himmelfarb, Jonathan

doi:10.1111/j.1523-1755.2004.00465.x

Cited by 665 publications

(509 citation statements)

References 51 publications

Supporting

Mentioning

461

Contrasting

Unclassified

Order By: Relevance

“…These findings appear to be in contrast to those obtained in human patients with moderate‐to‐severe CKD, in whom plasma F 2 ‐isoprostanes were significantly increased in many studies 1, 7, 10, 11, 12. Urinary and plasma F 2 ‐isoprostanes have been considered to be equivalent markers of chronic (but not acute) oxidative stress,15 but our different findings in cats with CKD could be because of sampling urine rather than plasma.…”

Section: Discussioncontrasting

confidence: 96%

“…F 2 ‐isoprostanes are a well‐studied indicator of lipid peroxidation and redox stress and have been shown in many studies to increase with advancing CKD in humans 1, 3, 6, 10, 11, 12. In addition, redox stress appears to contribute to disease progression in animal models of CKD,16, 17, 18, 19, 20 making it a possible therapeutic target.…”

Section: Discussionmentioning

confidence: 99%

“…Potential sources of renal oxidative stress include tubulointerstitial inflammation, systemic hypertension, and depletion or dysregulation of antioxidant pathways 5, 6, 7, 8. Various plasma biomarkers of oxidative stress, including F 2 ‐isoprostanes, have been shown to correlate with the stages of progressive CKD and declining glomerular filtration rate (GFR) in humans 1, 3, 6, 9, 10, 11, 12. F 2 ‐isoprostanes are formed in vivo by nonenzymatic, free radical‐catalyzed lipid peroxidation of arachidonic acid and are an established biomarker for oxidative injury in human patients across many disease states 13.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Urinary F₂‐Isoprostanes in Cats with International Renal Interest Society Stage 1–4 Chronic Kidney Disease

Whitehouse

Quimby

Wan

et al. 2017

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundF2‐isoprostanes, a biomarker of oxidant injury, increase with advancing chronic kidney disease (CKD) in humans. In cats, the relationship between CKD and oxidative stress is poorly understood.ObjectivesTo determine whether cats with advancing CKD have increasing urinary F2‐isoprostanes.AnimalsControl cats without evidence of CKD (≥6 years old; n = 11), and cats with IRIS stage 1 (n = 8), 2 (n = 38), 3 (n = 21), and 4 (n = 10) CKD.MethodsThis was a prospective observational study. Urinary F2‐isoprostanes (specifically free 15‐F2t‐isoprostanes) normalized to urine creatinine (IsoPs) were compared among groups and tested for correlations with blood pressure, proteinuria, serum creatinine concentration, and urine specific gravity. The IsoPs also were compared between cats with and without hypertension or proteinuria, and in cats fed predominantly standard versus renal diets.ResultsUrinary IsoPs were increased, but not significantly, in cats with stage 1 CKD (median 263 pg/mg creatinine; range, 211–380) compared to controls (182 pg/mg; range, 80–348) and decreased significantly from stage 1 through advancing CKD (stage 2, 144 pg/mg; range, 49–608; stage 3, 102 pg/mg; range, 25–158; stage 4, 67 pg/mg; range, 26–117; P < .01). Urinary IsoPs were inversely correlated with serum creatinine (r = −0.66, P < .0001).Conclusion and Clinical ImportanceUrinary IsoPs are significantly higher in early CKD (stage 1) compared to cats with more advanced CKD. Additional studies are warranted to characterize oxidative stress in cats with stage 1 CKD and determine whether early antioxidant treatments have a protective effect on CKD progression.

show abstract

Section: Discussioncontrasting

confidence: 96%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Urinary F₂‐Isoprostanes in Cats with International Renal Interest Society Stage 1–4 Chronic Kidney Disease

Whitehouse

Quimby

Wan

et al. 2017

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…The increased risk of CVD in this patient population is only partially explained by traditional (Framingham)5, 6 risk factors, and “nontraditional” factors likely influence the risk of CVD 7. Systemic inflammation has been proposed to contribute to the development of CVD in patients with CKD,8 as inflammatory markers, such as C‐reactive protein and interleukin‐6, are elevated in CKD 9, 10, 11, 12. In some observational studies, cytokines prospectively predicted the development of CVD 12…”

Section: Introductionmentioning

confidence: 99%

Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease

Jalal

Renner

Laskowski

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundEndothelial microparticles are associated with chronic kidney disease (CKD) and complement activation. We hypothesized that the complement pathway is activated in patients with CKD via endothelial microparticles and that complement activation correlates with endothelial dysfunction in CKD.Methods and ResultsWe analyzed complement data of 30 healthy subjects, 30 patients with stage III/IV CKD, and 30 renal transplant recipients with stage III/IV CKD, evaluating the potential correlation of complement fragments with brachial artery flow–mediated dilation, Chronic Kidney Disease Epidemiology Collaboration glomerular filtration rate, and urinary albumin/creatinine ratio. Endothelial microparticles were characterized via proteomic analysis and compared between study groups. Complement fragment Ba was significantly increased in CKD and post–kidney transplant CKD. Plasma Ba levels correlated significantly with lower brachial artery flow–mediated dilation, lower Chronic Kidney Disease Epidemiology Collaboration glomerular filtration rate, and higher urinary albumin/creatinine ratio. Factor D levels were significantly higher in the plasma microparticles of patients with CKD versus healthy controls. Plasma microparticles isolated from patients with CKD and containing factor D activated the alternative pathway in vitro.ConclusionThe alternative complement pathway is activated in CKD and correlates with endothelial dysfunction and markers of CKD. Future studies are needed to evaluate whether endothelial microparticles with increased factor D play a pathologic role in CKD‐associated vascular disease.Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT02230202.

show abstract

“…Several studies have reported that ROS are generated more in patients with diabetes, hyperlipidemia, smokers and other chronic inflammatory conditions [13]. Patients with neurodegenerative illnesses [14] diabetes and hypercholesterolemia [15] and children with juvenile chronic arthritis [16] were found to have elevated levels of total protein carbonyls, suggesting the potentiality of carbonylated proteins serving as a biomarkers for early diagnosis of these diseases.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Oxidative Stress Markers and Carotid Artery Intima-Media Thickness in Elderly Patients Without and with Coronary Artery Disease

et al. 2015

View full text Add to dashboard Cite

We aimed to assess whether measuring carotid intima-media thickness (CIMT) and oxidative stress markers such as protein carbonyls, malondialdehyde, nitrate and glutathione in plasma of elderly patients without and with coronary artery disease (CAD) identifies early risk for CAD. A total of 50 cases with cardiovascular risk factors over the age of 60 years without CAD, and 50 patients with angiographically documented CAD over the age of 60 years were included in the study. Control group consists of 200 healthy individuals without the risk factors. Demographic details were obtained from all the subjects and CIMT measured by high frequency ultrasound and oxidative stress markers such protein carbonyls, malondialdehyde and total glutathione were determined in plasma by spectrophotometric methods. The distribution of cardiovascular risk factors in without CAD and CAD cases were smokers (16 vs 56 %), hypertension (26 vs 64 %), diabetes (16 vs 56 %) and dyslipidemia (18 vs 58 %) and positive family history (4 vs 38 %). None of the control group had any cardiovascular risk factors. Among the CAD cases, 16 % had single vessel disease, 44 % had double vessel disease and 40 % had triple vessel disease. The CIMT was significantly increased in CAD cases as compared to cases without CAD and healthy controls. On the other hand, CIMT was significantly increased in cases without CAD as compared to healthy controls. CIMT also increased with the duration of diabetes in patients without CAD and severity of disease in CAD cases. The levels of oxidants like plasma malondialdehyde, protein carbonyls, were significantly elevated and antioxidant glutathione levels and nitrate levels were significantly reduced in cases with and without CAD as compared to healthy controls. Oxidative stress markers and CIMT was found to be significantly increased in patients with cardiovascular risk factors like diabetes, family history of CAD, dyslipidemia, hypertension and smoking when compared to patients without risk factors. In patients with diabetes, CIMT increased as duration of disease increases and also in poorly controlled diabetes. In CAD group, when number of vessel involvement (severity of coronary disease) increases, the CIMT also increases confirming that CIMT is a quantifiable risk factor for CAD.

show abstract

Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease

Cited by 665 publications

References 51 publications

Urinary F₂‐Isoprostanes in Cats with International Renal Interest Society Stage 1–4 Chronic Kidney Disease

Urinary F₂‐Isoprostanes in Cats with International Renal Interest Society Stage 1–4 Chronic Kidney Disease

Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease

Assessment of Oxidative Stress Markers and Carotid Artery Intima-Media Thickness in Elderly Patients Without and with Coronary Artery Disease

Contact Info

Product

Resources

About

Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease

Cited by 665 publications

References 51 publications

Urinary F2‐Isoprostanes in Cats with International Renal Interest Society Stage 1–4 Chronic Kidney Disease

Urinary F2‐Isoprostanes in Cats with International Renal Interest Society Stage 1–4 Chronic Kidney Disease

Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease

Assessment of Oxidative Stress Markers and Carotid Artery Intima-Media Thickness in Elderly Patients Without and with Coronary Artery Disease

Contact Info

Product

Resources

About

Urinary F₂‐Isoprostanes in Cats with International Renal Interest Society Stage 1–4 Chronic Kidney Disease

Urinary F₂‐Isoprostanes in Cats with International Renal Interest Society Stage 1–4 Chronic Kidney Disease