Increased Prevalence of Helicobacter Pylori Antibodies Among Nurses

Wilhoite, Scott; Ferguson, Donald J.; Soike, David R.; Kalbfleisch, John D.; Thomas, Eapen

doi:10.1097/00007611-199109001-00103

Cited by 14 publications

(20 citation statements)

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“…Other studies conducted among blood donors in developed countries have usually not revealed a decline in H. pylori seroprevalence similar to the one observed by us (5,7,15,20,26,(33)(34)(35)(36). A closer inspection of the previous data, however, unveils lower-than-expected seroprevalence rates above the age of 50 in several studies, (5,34,36), but few of them included subjects who were older than 60.…”

Section: Discussionsupporting

confidence: 70%

“…A closer inspection of the previous data, however, unveils lower-than-expected seroprevalence rates above the age of 50 in several studies, (5,34,36), but few of them included subjects who were older than 60. In the ages below 60, the deviant pattern was less clear also in our study.…”

Section: Discussionmentioning

confidence: 91%

“…In European epidemiological studies, blood donors are often used to represent the general population since all European countries have unpaid donors (34,36). The appropriateness of this assumption has not been rigorously tested for H. pylori seroprevalence.…”

mentioning

confidence: 99%

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Unexpected Decrease with Age of Helicobacter pylori Seroprevalence among Swedish Blood Donors

Sörberg¹,

Nyrén²,

Granström

2003

J Clin Microbiol

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Blood donors are often used as proxies for the general population in studies of Helicobacter pylori epidemiology. Our aim was to test if the age-specific seroprevalence rates among blood donors match with the corresponding rates in a random population sample. This descriptive study was based on sera obtained from 3,502 blood donors representing all Swedish counties and cities. An age-stratified random population sample of 1,030 from Stockholm County served as comparison. Sera were analyzed by an in-house enzyme-linked immunosorbent assay for H. pylori immunoglobulin G antibodies. In the population sample, we found the expected increase with age in the seroprevalence of H. pylori infection. This was true also among young blood donors, while the prevalence-by-age curve showed a deflection downward among blood donors who are > 50 years of age. In this age group, the probability of being seropositive was reduced by 73% (95% confidence interval [CI], 63 to 81%) relative to the population sample. Overall, the adjusted odds ratio for H. pylori seropositivity among blood donors was decreased by 43% (95% CI, 28 to 55%). Thus, it appears that blood donors who are H. pylori seropositive selectively disappear from the blood donor cohort. We speculate that H. pyloriseropositive blood donors may tolerate repeated bleedings less well than do noninfected individuals and/or that the general well-being among those who are infected may be somewhat impaired. Our unexpected observation indicates that blood donors may be less suitable as proxies for the general population in analytic studies of H. pylori infection and that the underlying cause needs further study.Helicobacter pylori is accepted as a principal cause of nonautoimmune chronic gastritis (10). Moreover, eradication of H. pylori prevents recurrence of peptic ulcers (14), and evidence for a causal role in gastric cancer is accumulating (11,17,30).H. pylori infections are mainly acquired in early childhood (13). In developing countries, the seroprevalence of the infection is higher than in developed countries, where it rises gradually with age (12,23). This latter phenomenon is considered to reflect a birth cohort effect. Hence, the higher infection prevalence in older individuals represents higher childhood infection rates in these birth cohorts rather than acquisition during adult life (1, 9).In European epidemiological studies, blood donors are often used to represent the general population since all European countries have unpaid donors (34, 36). The appropriateness of this assumption has not been rigorously tested for H. pylori seroprevalence.We took advantage of a large nationwide sample of blood donors, drawn for the purpose of investigating the seroprevalence of Borrelia burgdorferi infection in different parts of Sweden (28), to study also the age-specific seroprevalence of H. pylori infection, presuming that the blood donors were representative for the general population. We then compared the seroprevalence pattern among blood donors with that in a population contr...

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 91%

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Unexpected Decrease with Age of Helicobacter pylori Seroprevalence among Swedish Blood Donors

Sörberg¹,

Nyrén²,

Granström

2003

J Clin Microbiol

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“…More than 50% of people over 60 years are antibody positive [6], and there is an inverse association with social class [5], The nat ural reservoir is unknown and the mode of transmission is complex. Man-to-man transmission is possible (families, gastroscopy staff and nurses [7]), but also some jobs have high prevalence rates (staff in slaughterhouses [8] and vet erinary surgeons) suggesting a transmission from animal to man. In addition, H. pylori can be transmitted via endo scopes and biopsy instruments.…”

Section: Helicobacter Pylorimentioning

confidence: 99%

May <i>Helicohacter pylori</i> Be Important for Dermatologists

Rebora¹,

Drago²,

Parodi³

1995

Dermatology

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Helicohacter pylori, a microaerophilic gram-negative bacterium, is the major cause of gastritis, plays a key role in the etiology of peptic ulcer and is a risk factor for gastric cancer. Although 50% of the population is affected, dermatologists seem to be unaware of the impact H. pylori may have on cutaneous pathology. Among skin diseases, H. pylori has been related so far only with chronic urticaria and rosacea. In rosacea, histology of the stomach mucosa revealed that 84% of 31 patients were H. pylori positive. Twenty percent of them were serologically negative, but, overall, 100% of the 20 patients with both histology and serology were H. pylori positive with either test. The consistency between clinical success with metronidazole and abatement of H. pylori isolates and serology after treatment was an additional evidence suggesting an etiologic relationship between rosacea and H. pylori infection. Rosacea has often been linked with gastrointestinal disturbances. H. pylori, therefore, may link them to the well-known beneficial activity of metronidazole on rosacea lesions. The role of H. pylori is more probable in erythrotic rosacea than in its papulopustular and granulomatous stages. As in Bacillus suhtilis intoxication, a flush-inducing toxin cannot be excluded. Despite the difficulty to find patients accepting bioptic gastroscopies, large case control studies should be done before a causal relationship with urticaria and rosacea is firmly established.

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“…A higher prevalence of the infection has been observed in institutionalized patients, in submarine crews, in medical personnel and in children living together 96–101 . In one study, molecular fingerprinting showed that up to seven children in an institution were infected by a genetically identical strain; five of them were living in the same section 102 .…”

Section: Potential Genetic and Environmental Factors Contributing To mentioning

confidence: 99%

Review article: ‘true’ re‐infection of Helicobacter pylori after successful eradication – worldwide annual rates, risk factors and clinical implications

Zhang

Xia

Zhuang

et al. 2008

Aliment Pharmacol Ther

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Increased Prevalence of Helicobacter Pylori Antibodies Among Nurses

Cited by 14 publications

References 0 publications

Unexpected Decrease with Age of Helicobacter pylori Seroprevalence among Swedish Blood Donors

Unexpected Decrease with Age of Helicobacter pylori Seroprevalence among Swedish Blood Donors

May <i>Helicohacter pylori</i> Be Important for Dermatologists

Review article: ‘true’ re‐infection of Helicobacter pylori after successful eradication – worldwide annual rates, risk factors and clinical implications

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