Increased Platelet to Lymphocyte Ratio is Related to Slow Coronary Flow

Akboğa, Mehmet Kadri; Canpolat, Uğur; Balcı, Kevser Gülcihan; Akyel, Ahmet; Şen, Fatih; Yayla, Çağrı; Çay, Serkan; Aras, Dursun; Aydoğdu, Sinan

doi:10.1177/0003319715574625

Cited by 40 publications

(38 citation statements)

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“…However, the literature that was reviewed included no data about the association between PLR and the severity of degenerative AVS in patients with normal systolic function. [23456789] Degenerative AVS and aortic annular calcification have a close relationship with atherosclerotic changes in various vascular systems of the human body such as CAD and carotid atherosclerosis. [1011] Although the precise underlying pathophysiology of degenerative AVS still remains unclear, metabolic imbalances, particularly those including calcium and phosphorus accumulation, play a role as well.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of platelet-to-lymphocyte ratio in severe degenerative aortic valve stenosis

et al. 2016

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Background:Aortic valve stenosis (AVS) is the most common cause of left ventricular outflow obstruction, and its prevalence among elderly patients causes a major public health burden. Recently, platelet-to-lymphocyte ratio (PLR) has been recognized as a novel prognostic biomarker that offers information about both aggregation and inflammation pathways. Since PLR indicates inflammation, we hypothesized that PLR may be associated with the severity of AVS due to chronic inflammation pathways that cause stiffness and calcification of the aortic valve.Materials and Methods:We retrospectively enrolled 117 patients with severe degenerative AVS, who underwent aortic valve replacement and 117 control patients in our clinic. PLR was defined as the absolute platelet count divided by the absolute lymphocyte count. Severe AVS was defined as calcification and sclerosis of the valve with a mean pressure gradient of >40 mmHg.Results:PLR was 197.03 ± 49.61 in the AVS group and 144.9 ± 40.35 in the control group, which indicated a statistically significant difference (P < 0.001). A receiver operating characteristic (ROC) curve analysis demonstrated that PLR values over 188 predicted the severity of aortic stenosis with a sensitivity of 87% and a specificity of 70% (95% confidence interval = 0.734–0.882; P < 0.001; area under ROC curve: 0.808).Conclusion:We suggest that the level of PLR elevation is related to the severity of degenerative AVS, and PLR should be used to monitor patients' inflammatory responses and the efficacy of treatment, which will lead us to more closely monitor this high-risk population to detect severe degenerative AVS at an early stage.

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Section: Discussionmentioning

confidence: 99%

Predictive value of platelet-to-lymphocyte ratio in severe degenerative aortic valve stenosis

et al. 2016

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“…Because PLR is a ratio, it is relatively more stable than individual blood parameters, which may be altered by several variables (e.g., dehydration, overhydration, and blood specimen handling) [31]. The advantage of PLR calculation could be that it reflects the condition of both aggregation and inflammatory pathways and it may be more valuable than either platelet or lymphocyte count alone in the prediction of various inflammatory diseases including cardiovascular diseases [19,32]. In a previous study, Azab et al [33] showed that lower lymphocyte and higher platelet counts were significantly related to worse prognosis in patients with non-ST-elevation myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

Association between hematologic parameters and in‐hospital mortality in patients with infective endocarditis

Zencir

Akpek

Şenol

et al. 2015

The Kaohsiung J of Med Scie

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Early and accurate risk prediction is an important clinical demand in patients with infective endocarditis (IE). The platelet-to-lymphocyte ratio (PLR) is an independent predictor of worse prognosis in various cardiovascular diseases. The aim of this study was to determine the value of PLR in the prediction of in-hospital mortality among IE patients. We retrospectively analyzed the clinical, laboratory, and echocardiographic data of 59 adult patients with definite IE and in 40 adult controls. In-hospital mortality occurred in 16 (27%) patients. Vegetation size, levels of high-sensitive C-reactive protein and procalcitonin, neutrophil-to-lymphocyte ratio, and PLR were significantly higher in the in-hospital-mortality-positive group than in the in-hospital-mortality-negative group (p = 0.004, p = 0.009, p = 0.030, p = 0.001, and p = 0.008, respectively). Lymphocyte count was, however, significantly lower in the in-hospital-mortality-positive group (p = 0.004). In the receiver-operating characteristic analysis, PLRs over 191.01 predicted in-hospital mortality with 56.3% sensitivity and 81.4% specificity [area under the curve 0.725, 95% confidence interval (CI) 0.594-0.833; p = 0.0027]. In the multivariate analysis, PLR was found to be an independent predictor of in-hospital mortality in patients with IE (odds ratio 1.022, 95% CI 1.003-1.042; p = 0.021). In conclusion, higher PLR may predict in-hospital mortality in patients with IE.

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“…In most of the studies, total white blood cell count has not been the predictor of CSFP 6,13–15. In contrast, Akboga et al16 found that a higher white blood cell count is associated with CSFP. Regarding the red blood cell subtypes, results have also been diverse among studies.…”

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confidence: 95%

“…Furthermore, the elevated levels of hemoglobin11 and hematocrit15 have been associated with the CSFP. In addition to these regular complete blood cell count components, some novel biomarkers have also been found to be associated with the CSFP, including elevated neutrophil-to-lymphocyte ratio,14 increased platelet-to-lymphocyte ratio,16 and decreased lymphocyte-to-monocyte ratio 18. All these novel biomarkers are inflammation-based and have been useful in diagnosing other inflammatory diseases.…”

mentioning

confidence: 99%