Association between hematologic parameters and in‐hospital mortality in patients with infective endocarditis

Abstract

Early and accurate risk prediction is an important clinical demand in patients with infective endocarditis (IE). The platelet-to-lymphocyte ratio (PLR) is an independent predictor of worse prognosis in various cardiovascular diseases. The aim of this study was to determine the value of PLR in the prediction of in-hospital mortality among IE patients. We retrospectively analyzed the clinical, laboratory, and echocardiographic data of 59 adult patients with definite IE and in 40 adult controls. In-hospital mortality occurred in 16 (27%) patients. Vegetation size, levels of high-sensitive C-reactive protein and procalcitonin, neutrophil-to-lymphocyte ratio, and PLR were significantly higher in the in-hospital-mortality-positive group than in the in-hospital-mortality-negative group (p = 0.004, p = 0.009, p = 0.030, p = 0.001, and p = 0.008, respectively). Lymphocyte count was, however, significantly lower in the in-hospital-mortality-positive group (p = 0.004). In the receiver-operating characteristic analysis, PLRs over 191.01 predicted in-hospital mortality with 56.3% sensitivity and 81.4% specificity [area under the curve 0.725, 95% confidence interval (CI) 0.594-0.833; p = 0.0027]. In the multivariate analysis, PLR was found to be an independent predictor of in-hospital mortality in patients with IE (odds ratio 1.022, 95% CI 1.003-1.042; p = 0.021). In conclusion, higher PLR may predict in-hospital mortality in patients with IE.

Evaluation of Platelet Indices in Young Male Patients with Hepatitis C

“…Therefore, the platelet-to-lymphocyte ratio (PLR) may be altered by these disorders. PLR has been shown to be associated with inflammation and inflammation severity and is also described as an independent predictor of some infectious diseases such as infective endocarditis [15][16][17]. In this study, in light of the fact that platelet counts and sizes or lymphocyte counts may be altered in patients with HCV infection depending upon the severity of inflammation or fibrosis, we aimed to investigate the values and the roles of platelet indices and PLR in male patients with HCV infection compared with healthy controls.…”

“…Abnormal platelet indices have also been found to be associated with more severe illness and higher risk of death in intensive care unit patients [14]. Not only platelet counts, but also lymphocyte counts can be affected by chronic inflammatory diseases, infectious diseases, malignancies and myeloproliferative disorders [15][16][17]. Therefore, the platelet-to-lymphocyte ratio (PLR) may be altered by these disorders.…”

Letter: need to re-evaluate non-invasive markers for staging fibrosis in chronic delta hepatitis

“…1 Nevertheless, platelets may also be affected by many factors such as infections, chronic inflammatory diseases, some haematological disorders and drug use. [2][3][4][5] Therefore, when evaluating these noninvasive biomarkers that may affect the components of the non-invasive fibrosis biomarkers particular comorbidities need to be taken into consideration. However, the authors only excluded the patients with co-existing non-viral hepatitis liver diseases.…”

Uygun maliyetli ve kolay ulaşılabilir bir belirteç olarak platelet/lenfosit oranı

“…PLR has been evaluated in patients with several diseases including chronic inflamatory diseases, malignancies, myeloproliferative disorders, cardiovasculer diseases and infectious diseases [1][2][3][4][5][6][7][8][9][10][11][12][13] .…”

“…Furthermore, elevated PLR levels have been shown in patients with several diseases such as cancer (e.g., prostate, colorectal, cervical, ovarian, malignant pleural mesothelioma and surgically resected gastrointestinal stromal tumors), peripheral artery disease, hypertension, coronary artery disease, limb ischemia, poor prognostic myocardial infraction, infective endocarditis, exacerbation of chronic obstructive pulmonary disease (COPD), systemic lupus erythematosus (SLE), psoriasis vulgaris, Behçet's syndrome, pseudoexfoliation syndrome [1][2][3][4][5][6][7][8][9][10][11][12][13] . On the contrary, reduced PLR levels have been reported in patients with obstructive sleep apnea syndrome (OSAS) 6 .…”