Increased platelet activation in patients with slow coronary flow

Abstract

We tested the hypothesis that increased platelet activation may be present in patients with slow coronary flow (SCF) and may contribute to the pathogenesis of slow coronary flow phenomenon (SCFP). Fifty patients angiographically proven normal coronary flow (control group; mean age = 61.3 +/- 7.0 years, 43 male) and 50 patients with angiographically proven SCF in all coronary arteries (patient group; man age = 62.7 +/- 6.7 years, 38 male) were included in the present study. Coronary flow rates of all subjects were documented by Thrombolysis In Myocardial Infarction frame count (TIMI frame count). Patients with a corrected TIMI frame count greater than two standard deviations from normal published range for the particular vessel were considered as having SCF. Complete blood count and mean platelet volume (MPV) was measured from whole blood sample with Abbott Cell-Dyne 4000 cell counter. Plasma sP-selectin concentrations were analyzed with sP-Selectin ELISA kit. There were no statistically significant differences between the two groups with respect to baseline demographic, clinical and lipid parameters. Not only MPV values but also plasma sP-selectin levels were significantly higher in patients with the patients with SCF compared to those of controls (for MPV; 8.2 +/- 0.7 vs. 7.2 +/- 0.6 fl, P < 0.001, for sP-Selectin; 1.5 +/- 0.3 vs. 1.0 +/- 0.2 ng/ml, P < 0.001). Interestingly, significant positive correlations were detected between mean TIMI frame counts and MPV and sP-selectin levels (for MPV; r = 0.56, P < 0.001, for sP-selectin r = 0.67, P < 0.001). The current study demonstrates that platelet activity is increased in the patients with SCF compared to that of the patients with normal coronary flow.

Increased Platelet to Lymphocyte Ratio is Related to Slow Coronary Flow

“…Among aforementioned etiological causes, enhanced thrombogenicity has been known as another player in SCF pathogenesis. 17 Gokce et al 7 showed that patients with SCF had increased platelet aggregability in the ristocetin groups when compared with the control group. Turkmen et al 18 illustrated that factor XI and XII activities were significantly higher in patients with SCF when compared to the control group.…”

An Evaluation of Mean Platelet Volume and Serum Lipid Profile in Patients with Fibromyalgia Syndrome

“…[22] Futhermore, Han et al [23] reported that MPV is a predictive marker for stroke or CAD, and Greisenegger et al [24] determined that an elevated MPV is associated with a poorer outcome for acute ischemic cerebrovascular events independent of other clinical parameters. Previous studies have also reported that high MPV levels are related with cardiovascular risk [25] and that these levels increase in patients with cardiac conditions [26][27][28] who have a poor prognosis.…”

Potential mechanisms of the acute coronary syndrome presentation in patients with the coronary slow flow phenomenon — Insight from a plasma proteomic approach

“…Clinical investigations have identified that these cohorts of patients have low resting coronary sinus oxygen saturation rates [7] and increased platelet activation [8] compared with control subjects. Basic molecular studies have also identified a range of elevated cardiovascular disease plasma markers such as homocysteine [9], endothelin-1 [10] and soluble adhesion molecules ICAM-1, VCAM-1 and E-selectin [11] in this group of patients.…”