Increased Plasma Transforming Growth Factor‐β1 in Migraine

Ishizaki, Kumiko; Takeshima, Takao; Fukuhara, Yoko; Araki, Haruko; Nakaso, Kazuhiro; Kusumi, Masayoshi; Nakashima, Kenichiro

doi:10.1111/j.1526-4610.2005.00246.x

Cited by 49 publications

(42 citation statements)

References 23 publications

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“…Interestingly, BDNF is up-regulated in primary sensory neurons by inflammation [10, 26]. Peripheral and cerebrospinal fluid levels of pro-inflammatory cytokines have been found to be elevated in migraineurs [27–29]. Cytokine-induced release of pain modulators such as BDNF from trigeminal neurons might underline the interaction of inflammatory and neuronal pathways leading to neurogenic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Brain-derived neurotrophic factor in primary headaches

et al. 2012

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Brain derived neurotrophic factor (BDNF) is associated with pain modulation and central sensitization. Recently, a role of BDNF in migraine and cluster headache pathophysiology has been suspected due to its known interaction with calcitonin gene-related peptide. Bi-center prospective study was done enrolling four diagnostic groups: episodic migraine with and without aura, episodic cluster headache, frequent episodic tension-type headache, and healthy individuals. In migraineurs, venous blood samples were collected twice: outside and during migraine attacks prior to pain medication. In cluster headache patients serum samples were collected in and outside cluster bout. Analysis of BDNF was performed using enzyme-linked immunosorbent assay technique. Migraine patients revealed significantly higher BDNF serum levels during migraine attacks (n = 25) compared with headache-free intervals (n = 53, P < 0.01), patients with tension-type headache (n = 6, P < 0.05), and healthy controls (n = 22, P < 0.001). There was no significant difference between patients with migraine with aura compared with those without aura, neither during migraine attacks nor during headache-free periods. Cluster headache patients showed significantly higher BDNF concentrations inside (n = 42) and outside cluster bouts (n = 24) compared with healthy controls (P < 0.01, P < 0.05). BDNF is increased during migraine attacks, and in cluster headache, further supporting the involvement of BDNF in the pathophysiology of these primary headaches.

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Section: Discussionmentioning

confidence: 99%

Brain-derived neurotrophic factor in primary headaches

et al. 2012

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“…Furthermore, TGF-␤1 treatment attenuated neuropathic pain (26), and also, TGF-␤ family members were implicated in the modulation of chronic and acute pain perception through the regulation of genes encoding endogenous opioids (27). Also, protein levels of TGF-␤1 are significantly increased in the plasma (25) and cerebrospinal fluid (46) of patients with migraines. To evaluate in vivo the role of TGF-␤1 in nociceptive processes and its involvement in the regulation of Cdk5 activity, we removed TG and DRG from the Tgf-␤1 Ϫ/Ϫ mice and assessed the p35 expression levels and Cdk5 kinase activity in those tissues.…”

Section: Discussionmentioning

confidence: 99%

“…TGF-␤1 has also been implicated in the pathology of Alzheimer disease (22,23) and its overexpression in astrocytes can lead to excessive deposition of extracellular matrix components in the brain resulting in neurological disease (24). Recent reports indicate that TGF-␤1 may play a role in migraine and neuropathic pain (25)(26)(27). However, the molecular mechanisms underlying its involvement in nociceptive signaling are still far from clear.…”

Section: Cyclin-dependent Kinase 5 (Cdk5)mentioning

confidence: 99%

Transforming Growth Factor-β1 Regulates Cdk5 Activity in Primary Sensory Neurons

Utreras

Keller

Terse

et al. 2012

Journal of Biological Chemistry

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Background: Cdk5 participates in the regulation of nociceptive signaling and peripheral inflammation increase its activity. Results: TGF-␤1, an immunoregulatory cytokine that plays a key role during inflammation, can increase Cdk5 activity. Conclusion: There is active cross-talk between TGF-␤ and Cdk5 signaling pathways that affects pain. Significance: Understanding the cross-talk between inflammation and pain signaling is important for developing novel therapies to treat pain associated with chronic inflammatory diseases.

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“…31,32 This study finding of endothelial activation in migraine leads to speculation regarding the nature of the relation. Ictal studies of migraine that have documented increased vWF, 25 endothelin-1, 33 soluble intercellular adhesion molecule, tissue necrosis factor, 34 transforming growth factor-␤1, 35 and matrix metalloproteinase-9 36 suggest that migraine may directly activate the endothelium. An alternative and not mutually exclusive hypothesis is that endothelial dysfunction causes migraine.…”

Section: Hypercoagulabitymentioning

confidence: 99%

Migraine and Biomarkers of Endothelial Activation in Young Women

Tietjen

Herial

White

et al. 2009

Stroke

124

136

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Background and Purpose-There is mounting evidence of endothelial activation and dysfunction in migraine. Our objectives were to determine in a population of premenopausal women whether endothelial activation markers are associated with migraine. Methods-Women (18 to 50 years) with and without migraine and free from cardiovascular disease were evaluated with tests of coagulation (von Willebrand factor activity, prothrombin fragment), fibrinolysis (tissue-type plasminogen activator antigen), inflammation (high-sensitivity C-reactive protein), and oxidative stress (homocysteine, total nitrate/nitrite concentrations, thiobarbituric acid-reactive substances). Results-Sixty-one participants had migraine with aura (MA), 64 had migraine without aura (MO), and 50 were controls.Compared with controls, women with migraine had higher adjusted odds ratios for elevated von Willebrand factor activity of 6.51 (95% CI,

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Increased Plasma Transforming Growth Factor‐β1 in Migraine

Abstract: TGF-beta1 in PPP was significantly increased in patients with migraine during headache-free periods. TGF-beta1 may play some role in the development of migraine headache.

Cited by 49 publications

References 23 publications

Brain-derived neurotrophic factor in primary headaches

Brain-derived neurotrophic factor in primary headaches

Transforming Growth Factor-β1 Regulates Cdk5 Activity in Primary Sensory Neurons

Migraine and Biomarkers of Endothelial Activation in Young Women

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