Migraine and Biomarkers of Endothelial Activation in Young Women

Abstract

Background and Purpose-There is mounting evidence of endothelial activation and dysfunction in migraine. Our objectives were to determine in a population of premenopausal women whether endothelial activation markers are associated with migraine. Methods-Women (18 to 50 years) with and without migraine and free from cardiovascular disease were evaluated with tests of coagulation (von Willebrand factor activity, prothrombin fragment), fibrinolysis (tissue-type plasminogen activator antigen), inflammation (high-sensitivity C-reactive protein), and oxidative stress (homocysteine, total nitrate/nitrite concentrations, thiobarbituric acid-reactive substances). Results-Sixty-one participants had migraine with aura (MA), 64 had migraine without aura (MO), and 50 were controls.Compared with controls, women with migraine had higher adjusted odds ratios for elevated von Willebrand factor activity of 6.51 (95% CI,

Migraine and Stroke

“…In a young, relatively healthy cohort of women, strong associations between biomarkers of endothelial activation and migraine were found. 43 These include von Willebrand factor activity, C-reactive protein, tissue-type plasminogen activator antigen, and total nitrite/nitrate concentration and the association was generally stronger for MA. Particularly the role of von Willebrand factor in the migraine-stroke association has been investigated.…”

Migraine-Associated Cerebrovascular Disorders

“…Это может привести к активации прокоагулянтных, провоспалительных и пролифератив-ных механизмов, которые предрасполагают к развитию атеросклероза. У пациентов с мигренью отмечается повы-шение активности ключевых биомаркеров дисфункции эндотелия, таких как фактор von Willebrand (vWF), C-реактивный белок и уровни нитратов/нитритов, а также циркулирующих эндотелиальных клеток-предшественни-ков, что коррелирует с более длительной продолжитель-ностью заболевания [18]. Важно отметить, что во время приступа мигрени отмечается повышение уровня фактора vWF и фактора активации тромбоцитов (ФАТ) [19].…”

“…Одним из таких факторов может служить часто выявляемый полиморфизм гена MTHFR (methylenetetrahydrofolate reducase), который может объяснять повы-шенный риск ИИ при мигрени с аурой [21,22]. Ген MTHFR кодирует ключевой фермент метаболизма фолата и гомо-цистеина и связан с восприимчивостью к мигрени с аурой.…”

Serum L-arginine and dimethylarginine levels in migraine patients with brain white matter lesions

“…Despite the growing evidence of oxidative stress and vascular endothelial activation in migraine (23)(24)(25)(26)(27), the abovementioned biomarkers of endothelial dysfunction have not been comprehensively analyzed in relation to WMLs. Therefore, our objective in the present study was to quantify the L-arginine, ADMA and SDMA serum concentrations of migraine patients F o r P e e r R e v i e w 4 with or without cerebral WMLs in a headache-free period, to detect group differences between lesional and non-lesional migraineurs, to investigate the effect of migraine characteristics, and to determine the differences between migraine patients and controls.…”