Increased plasma osteoprotegerin levels are associated with the presence and severity of acute coronary syndrome

Ren, Manyi; Sui, Shujian; Zhang, Yun; Xu, Fang; Xu, Xiaoqun; Zhao, Jing; Du, Yimeng; Liu, Weihua

doi:10.2143/ac.63.5.2033230

Cited by 35 publications

(29 citation statements)

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“…Ren et al . [ 21 ] have further confirmed that increased plasma OPG levels are associated with the presence and severity of acute coronary syndrome. These studies suggest the potential prognostic utility of OPG as a biomarker in a clinical practice.…”

Section: Discussionmentioning

confidence: 83%

Association between Osteoprotegerin gene polymorphisms and risk of coronary artery disease: A systematic review and meta-analysis

Jia

et al. 2017

Balkan Journal of Medical Genetics

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Osteoprotegerin (OPG) has been demonstrated to be a novel biomarker for predicting prevalence and severity of coronary artery disease (CAD). Furthermore, recent studies have shown that OPG gene polymorphisms are associated with a susceptibility to CAD. However, published studies showed inconsistent results. Therefore, a meta-analysis of eligible studies reporting the association between OPG gene polymorphisms and CAD was carried out. A systematic search was conducted using PubMed, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Chinese Wan Fang databases. Odds ratio (OR) with corresponding 95% confidence interval (95% CI) were calculated. Overall, six eligible studies were included and four OPG gene polymorphisms (G209A, T245G, T950C and G1181C) were further evaluated for the association with susceptibility to CAD in this meta-analysis. Meta-analysis showed that G1181C and T950C polymorphisms were strongly associated with the risk of CAD, but no association existed between G209A and T245G polymorphisms and the risk of CAD. In conclusion, our meta-analysis is the first report to estimate the association between OPG gene polymorphisms and susceptibility to CAD. Further large scale case-control studies with rigorous design should be conducted to confirm the above conclusions in the future.

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Section: Discussionmentioning

confidence: 83%

Association between Osteoprotegerin gene polymorphisms and risk of coronary artery disease: A systematic review and meta-analysis

Jia

et al. 2017

Balkan Journal of Medical Genetics

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“…HBV cccDNA serves as the template for transcription of all four viral mRNAs (3.5, 2.4, 2.1, and 0.7 kb) (Ren et al, 2019). To determine whether the reduction of HBV DNA was due to a decrease in the mRNA levels, HBV RNAs were analyzed by realtime PCR analysis.…”

Section: Inhibitory Effects Of Plerixafor and Resatorvid On Hbv Repli...mentioning

confidence: 99%

“…Viral entry into the hepatocyte is mediated by the binding of the NTCP receptor to the pre-S1 domain of L-HBsAg (Ren et al, 2019). Based on the susceptibility of HepG2-NTCP cells to hepatitis B virus particles, a cell model of hepatitis B virus infection was established.…”

Section: Inhibitory Effect Of Plerixafor and Resatorvid On Hbv Replic...mentioning

confidence: 99%

Plerixafor and resatorvid inhibit hepatitis B virus in vitro by upregulating elongation factor Tu GTP-binding domain containing 2

Cai

Li²,

Hu³

et al. 2023

Front. Cell. Infect. Microbiol.

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BackgroundAn increase in the demand for a functional cure has accelerated research on new methods of therapy for chronic hepatitis B, which is mainly focused on restoring antiviral immunity for controlling viral infections. Previously, we had described elongation factor Tu GTP-binding domain containing 2 (EFTUD2) as an innate immune regulator and suggested that it might be an antiviral target.MethodsIn this study, we generated the Epro-LUC-HepG2 cell model for screening compounds that target EFTUD2. Plerixafor and resatorvid were screened from 261 immunity and inflammation-related compounds due to their ability to highly upregulate EFTUD2. The effects of plerixafor and resatorvid on hepatitis B virus (HBV) were examined in HepAD38 cells and HBV-infected HepG2-NTCP cells.ResultsThe dual-luciferase reporter assays showed that the EFTUD2 promoter hEFTUD2pro-0.5 kb had the strongest activity. In Epro-LUC-HepG2 cells, plerixafor and resatorvid significantly upregulated the activity of the EFTUD2 promoter and the expression of the gene and protein. In HepAD38 cells and HBV-infected HepG2-NTCP cells, treatment with plerixafor and resatorvid strongly inhibited HBsAg, HBV DNA, HBV RNAs, and cccDNA in a dose-dependent manner. Furthermore, the anti-HBV effect was enhanced when entecavir was administered along with either of the previous two compounds, and the effect could be blocked by knocking down EFTUD2.ConclusionWe established a convenient model for screening compounds that target EFTUD2 and further identified plerixafor and resatorvid as novel HBV inhibitors in vitro. Our findings provided information on the development of a new class of anti-HBV agents that act on host factors rather than viral enzymes.

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“…The consumption of PV and wind power has to take into account the time characteristics, and Chen et al ( 2022) [5] defined DLDN, which proposed a novel interactive optimization strategy that promotes PV power consumption capacity but does not consider combining multiple energy sources. Ren et al ( 2018) [6] and Yao et al (2019) [7] proposed a multi-time scale active and reactive power coordination control method based on the model prediction function, which reduces the load fluctuation caused by the unstable power output of distributed energy sources but lacks in the field of new energy consumption. At present, one of the most effective ways to absorb photoelectric and wind power is to compensate for the power of the distribution network by hydroelectric and thermal power [8] .…”

mentioning

confidence: 99%

Scheduling optimization of wind-solar power generation system based on Power to Gas

Wang

Wen

2023

J. Phys.: Conf. Ser.

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Storage technology and consumption technology can reduce the amount of abandoned wind and sunlight, improve the utilization of new energy, and reduce cost. Firstly, this paper describes the role of P2G (Power to Gas) technology in the field of new energy consumption, then builds the economic cost-optimal day-ahead optimal dispatch model based on a microgrid, examining the ability of P2G devices to consume new energy. Finally, three different scenarios are applied in the example for verification. The calculation example proves that P2G devices have a good effect in the field of scenery consumption and reduce the cost of the microgrid.

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Increased plasma osteoprotegerin levels are associated with the presence and severity of acute coronary syndrome

Abstract: Increased plasma osteoprotegerin levels are associated with the presence and severity of acute coronary syndrome.

Cited by 35 publications

References 0 publications

Association between Osteoprotegerin gene polymorphisms and risk of coronary artery disease: A systematic review and meta-analysis

Association between Osteoprotegerin gene polymorphisms and risk of coronary artery disease: A systematic review and meta-analysis

Plerixafor and resatorvid inhibit hepatitis B virus in vitro by upregulating elongation factor Tu GTP-binding domain containing 2

Scheduling optimization of wind-solar power generation system based on Power to Gas

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