Increased plasma miR-146a levels are associated with subclinical atherosclerosis in newly diagnosed type 2 diabetes mellitus

Guo, Wen; Li, Xiaona; Li, Jie; Lü, Jing; Wu, Juan; Zhu, Wen; Qin, Pei; Xu, Nianzhen; Zhang, Qun

doi:10.1016/j.jdiacomp.2020.107725

Cited by 12 publications

(10 citation statements)

References 29 publications

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“…The levels of miR-146a-5p were high in chronic DFU subjects compared to their acute counterparts, and in endothelial cells exposed to HGM in vitro compared to the control. This finding is in line with other reports where higher levels of miR-146a were reported in DFU and atherosclerosis cases [ 39 , 40 , 41 ]. Contradictory to our data, a lowered expression of miR-146a was assessed which was seen to delay healing response in diabetic mice [ 42 ]; however, few studies have suggested miR-146a as inflammation-inducible miRNA in various disease conditions [ 43 , 44 , 45 ].…”

Section: Discussionsupporting

confidence: 93%

LncRNA NEAT1/miR-146a-5p Axis Restores Normal Angiogenesis in Diabetic Foot Ulcers by Targeting mafG

Architha,

Juanitaa,

Vijayalalitha

et al. 2024

Cells

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Non-healing lesions in diabetic foot ulcers are a significant effect of poor angiogenesis. Epigenetic regulators, mainly lncRNA and miRNA, are recognized for their important roles in disease progression. We deciphered the regulation of lncRNA NEAT1 through the miR-146a-5p/mafG axis in the progression of DFU. A lowered expression of lncRNA NEAT1 was associated with dysregulated angiogenesis through the reduced expression of mafG, SDF-1α, and VEGF in chronic ulcer subjects compared to acute DFU. This was validated by silencing NEAT1 by SiRNA in the endothelial cells which resulted in the transcriptional repression of target genes. Our in silico analysis identified miR-146a-5p as a potential target of lncRNA NEAT1. Further, silencing NEAT1 led to an increase in the levels of miR-146a-5p in chronic DFU subjects. This research presents the role of the lncRNA NEAT1/miR-146a-5p/mafG axis in enhancing angiogenesis in DFU.

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Section: Discussionsupporting

confidence: 93%

LncRNA NEAT1/miR-146a-5p Axis Restores Normal Angiogenesis in Diabetic Foot Ulcers by Targeting mafG

Architha,

Juanitaa,

Vijayalalitha

et al. 2024

Cells

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“…After titles and abstracts screening, 81 nonrelevant records were excluded. The remaining 60 articles and eight additional articles identified from retrieved studies were included in the final meta‐analysis (Al‐Harbi et al, ; Al‐Salihi, Ajeena, Al‐Kashwan, & Al‐Lebban, ; Zidan, El Mougy, Moustafa, El attar, & Mohamed, ; Benrahma et al, ; Bluthner et al, ; Cao, Huang, Mao, & Gao, ; Chang et al, ; Chen, Ning, Zhu, Li, & Shi, ; Chen et al, ; P. Chen, Pan, Sun, Bai, & Fu, ; Dai & Yu, ; El Hajj Chehadeh et al, ; Eroglu et al, ; Errera et al, ; Fekih‐Mrissa et al, ; Fujita et al, ; Guo, Pan, Chu, Guo, & Sun, ; Guo et al, ; Hu, Zhang, Fang, Qin, & Liu, ; Hu, Gan, Li, & Bi, ; Jimenez‐Ramirez et al, ; Ksiazek, Bednarek‐Skublewska, & Buraczynska, ; Lin, Wang, & Liu, ; Liu et al, ; Luo, Yan, Li, Cheng, & Song, ; Luo, Yan, Ma, Cheng, & Song, ; Mao, Gao, Qin, & Shi, ; Mehri et al, ; Mei, Chen, & Zheng, ; Mtiraoui et al, ; Neugebauer, Baba, & Watanabe, ; Nithya et al, ; Odawara & Yamashita, ; Pirozzi et al, ; Qiu, ; Rahimi et al, ; Ramanathan, Harichandana, Kannan, Elumalai, & Sfd, ; Raza, Abbas, Siddiqi, & Mahdi, ; Settin, El‐Baz, Ismaeel, Tolba, & Allah, ; Shang, Wang, & Liu, ; Shi, He, Cheng, Wang, & Liu, ; J. Shi, Li, Yu, Chen, & Tao, ; Shpichinetsky et al, ; Soares et al, ; J. Sun, Xu, Xue, Zhu, & Lu, ; Sun, Xu, & Zhu, ; Sun, Xu, Zhu, & Lu, ; Sun, Xu, Lu, & Zhu, ; Sun, Chen, et al, ; Sun, Wang, Shi, & Yang, ; Wang et al, ; Wang, Hu, Xiao, & Wan, ; Wang, Wang, & Li, ; Wang, Wang, Xue, Chen, & Zou,…”

Section: Resultsmentioning

confidence: 99%

“…The remaining 60 articles and eight additional articles identified from retrieved studies were included in the final meta-analysis (Al-Harbi et al, 2015;Al-Salihi, Ajeena, Al-Kashwan, & Al-Lebban, 2016;Zidan, El Mougy, Moustafa, El attar, & Mohamed, 2019;Benrahma et al, 2012;Bluthner et al, 1999;Cao, Huang, Mao, & Gao, 2005;Chang et al, 2011;Chen, Ning, Zhu, Li, & Shi, 2004;Chen et al, 2010;P. Chen, Pan, Sun, Bai, & Fu, 2008;Dai & Yu, 2012;El Hajj Chehadeh et al, 2016;Eroglu et al, 2007;Errera et al, 2006;Fekih-Mrissa et al, 2017;Fujita et al, 1999;Guo, Pan, Chu, Guo, & Sun, 2005;Guo et al, 2002;Hu, Zhang, Fang, Qin, & Liu, 2009;Hu, Gan, Li, & Bi, 2001;Jimenez-Ramirez et al, 2017;Ksiazek, Bednarek-Skublewska, & Buraczynska, 2004;Lin, Wang, & Liu, 2009;Liu et al, 2014;Luo, Yan, Li, Cheng, & Song, 2007;Luo, Yan, Ma, Cheng, & Song, 2008;Mao, Gao, Qin, & Shi, 2004;Mehri et al, 2010;Mei, Chen, & Zheng, 2012;Mtiraoui et al, 2007;Neugebauer, Baba, & Watanabe, 1998;Nithya et al, 2017;Odawara & Yamashita, 1999;Pirozzi et al, 2018;Qiu, 2009;…”

Section: Study Searchmentioning

confidence: 99%

Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility

Meng

Liu

Ma³

et al. 2019

Molec Gen & Gen Med

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IntroductionMethylenetetrahydrofolate reductase (MTHFR) is essential in mediating folate metabolism, and thus plays an important role in diabetes and diabetic complications. MTHFR C677T (rs1801133 C>T) polymorphism has been proposed to be linked with type 2 diabetes mellitus (T2DM) susceptibility. However, the conclusions are inconsistent. Therefore, we rechecked their linkage aiming to obtain a more reliable estimation by performing an updated meta‐analysis.MethodsWe searched electronic databases PubMed, EMBASE, CNKI, and Wanfang to obtain studies updated to October 2019.ResultsAfter carefully screening, we finally incorporated 68 studies with 10,812 cases and 8,745 controls. The genotype frequency of C677T polymorphism was analyzed pooled to generate odds ratios (ORs) and 95% confidence intervals (CIs). Pooled results presented that MTHFR C677T polymorphism was significantly associated with T2DM under homozygous (OR = 1.64, 95% CI = 1.39–1.94), heterozygous (OR = 1.38, 95% CI = 1.20–1.59), recessive (OR = 1.41, 95% CI = 1.23–1.61), dominant (OR = 1.47, 95% CI = 1.27–1.70), and allele (OR = 1.37, 95% CI = 1.23–1.52) genetic models. Stratified analysis demonstrated that C677T genotype was associated with T2DM in Asian populations, but not Caucasian and African populations.ConclusionOur results indicated that MTHFR C677T polymorphism confers to T2DM, especially in Asian populations. Much more large‐scale case–control studies are needed to strengthen such conclusion in the future.

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“…In addition, were expressed in patients' peripheral blood, and have become promising biomarkers for diagnosis, risk stratification and prognosis prediction (Chen et al, 2015;Huang Y. et al, 2017;Huang YQ. et al, 2017;Guo et al, 2020;Sandeep Singh et al, 2020). With more in-depth investigation, miRNA is also connected to several primary disorders in the development of atherosclerosis.…”

Section: Exosome-mediated Diagnosismentioning

confidence: 99%

Advances of nanoparticle-mediated diagnostic and theranostic strategies for atherosclerosis

Lin,

Chen,

Yan

et al. 2023

Front. Bioeng. Biotechnol.

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Atherosclerotic plaque remains the primary cause of morbidity and mortality worldwide. Accurate assessment of the degree of atherosclerotic plaque is critical for predicting the risk of atherosclerotic plaque and monitoring the results after intervention. Compared with traditional technology, the imaging technologies of nanoparticles have distinct advantages and great development prospects in the identification and characterization of vulnerable atherosclerotic plaque. Here, we systematically summarize the latest advances of targeted nanoparticle approaches in the diagnosis of atherosclerotic plaque, including multimodal imaging, fluorescence imaging, photoacoustic imaging, exosome diagnosis, and highlighted the theranostic progress as a new therapeutic strategy. Finally, we discuss the major challenges that need to be addressed for future development and clinical transformation.

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Increased plasma miR-146a levels are associated with subclinical atherosclerosis in newly diagnosed type 2 diabetes mellitus

Cited by 12 publications

References 29 publications

LncRNA NEAT1/miR-146a-5p Axis Restores Normal Angiogenesis in Diabetic Foot Ulcers by Targeting mafG

LncRNA NEAT1/miR-146a-5p Axis Restores Normal Angiogenesis in Diabetic Foot Ulcers by Targeting mafG

Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility

Advances of nanoparticle-mediated diagnostic and theranostic strategies for atherosclerosis

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