Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia

Xu, Jimin; Jiao, Yumei; Xing, Mengjuan; Lin, Yezhe; Su, Yousong; Ding, Wenhua; Zhu, Cuizhen; Peng, Yanmin; Qi, Dake; Cui, Donghong

doi:10.1136/gpsych-2018-100018

Cited by 16 publications

(11 citation statements)

References 37 publications

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“…More studies have shown that the role of leptin in protecting cell survival, promoting apoptosis, and dopamine regulation may be the main mechanism for improving the psychopathological symptoms of schizophrenia (46). A previous study found that plasma leptin levels were negatively correlated with PANSS depression factor scores (r = −0.255, Bonferroni corrected P = 0.028) (47). These findings support the hypothesis that leptin is a predictor of the reduction of negative symptoms in schizophrenia.…”

Section: Discussionsupporting

confidence: 66%

Do Leptin Play a Role in Metabolism–Related Psychopathological Symptoms?

Zhang

Yao³

et al. 2021

Front. Psychiatry

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Objectives: Leptin is a crucial regulator of energy balance and is associated with obesity. In recent years, it has also been recognized as involved in the psychopathological mechanism. Our study aimed to elucidate the relationships between serum leptin levels, body mass index (BMI), and psychopathology symptoms in patients with schizophrenia.Methods: A cross-sectional assessment of 324 inpatients with schizophrenia was conducted. Schizophrenia symptoms were measured using the Positive and Negative Syndrome Scale (PANSS) and the Brief Psychiatric Rating Scale (BPRS). Serum leptin levels were assessed by the Enzyme-Linked Immunosorbent Assay (ELISA).Results: Significant differences in sex, BMI, and negative symptom subscale (PANSS-N) scores were found between the groups with high and low leptin levels in the study. Leptin levels were positively correlated with BMI (B = 2.322, t = 9.557, P < 0.001) and negatively correlated with PANSS-N scores (B = −0.303, t = −2.784, P = 0.006).Conclusions: Our results suggest that the increase in leptin levels is responsible for antipsychotic-induced weight gain and improved psychopathological symptoms.

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Section: Discussionsupporting

confidence: 66%

Do Leptin Play a Role in Metabolism–Related Psychopathological Symptoms?

Zhang

Yao³

et al. 2021

Front. Psychiatry

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“…Studies on the relationship between, psychotic disorders, especially schizophrenia, also present divergent results [65,66]. Indeed, two recent meta-analyses showed an increase in leptin for schizophrenia patients compared to controls, with more marked elevation during decompensations episodes [67,68]. Martorell and colleagues, in their study published in 2019, detected increased leptin levels in the early stages of psychosis [69].…”

Section: Leptin and Psychiatric Illnessesmentioning

confidence: 99%

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

et al. 2020

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Antipsychotic-induced weight gain is the most prevalent somatic adverse event occurring in patients treated by antipsychotics, especially atypical antipsychotics. It is of particular interest because of its repercussion on cardiovascular morbidity and mortality especially now that the use of second-generation antipsychotics has been extended to other mental health illnesses such as bipolar disorders and major depressive disorder. The mechanism underlying antipsychotics-induced weight gain is still poorly understood despite a significant amount of work on the topic. Recently, there has been an ongoing debate of tremendous research interest on the relationship between antipsychotic-induced weight gain and body weight regulatory hormones such as leptin. Given that, researchers have brought to light the question of leptin's role in antipsychotic-induced weight gain. Here we summarize and discuss the existing evidence on the link between leptin and weight gain related to antipsychotic drugs, especially atypical antipsychotics.

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“…In particular, depressed factor (total score of items G2, G3, G6 in the general psychopathology subscale), one of five factor models of PANSS was found to connect with clinical features and biomarkers in recent studies (22)(23)(24). Hence, we listed the depressed subscale separately for identical analysis.…”

Section: Clinical Symptoms Assessmentsmentioning

confidence: 99%

Leptin Methylation and mRNA Expression Associated With Psychopathology in Schizophrenia Inpatients

et al. 2022

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Leptin involved in the regulation of dopaminergic neurons of the central nervous system may confirm the hypothesis of neurodevelopment in schizophrenic patients. However, specific genetic mechanisms are undefined. Therefore, we aimed to explore the regulation of DNA methylation of leptin promoters and mRNA expression in patients with schizophrenia. A cross-sectional study enrolled 40 patients and 40 healthy controls from the Beijing Huilongguan Hospital in China. The leptin methylation levels and mRNA expression were examined by highly sensitive mass spectrometry based on the MassARRAY System and real-time quantitative polymerase chain reaction (qPCR). The Positive and Negative Symptoms Scale (PANSS) was applied to estimate the clinical symptoms of patients. The LEP-CpG7 and CpG15 methylation in patients were significantly higher than in healthy controls (P < 0.05). The LEP-CpG11, CpG33.34.35, CpG36 methylation, and mRNA expression decreased significantly in patients compared with healthy controls (P < 0.05). After controlling gender, age, BMI, dose of antipsychotic and duration of illness, LEP-CpG7 methylation was negatively associated with PANSS positive symptoms subscore (r = −0.485, P = 0.005). In addition, LEP-mRNA expression was negatively correlated with PANSS total score (r = −0.385, P = 0.03) and positive subscale (r = −0.392, P = 0.026). Nevertheless, only the LEP-CpG7 methylation level remained negatively correlated to the PANSS positive subscore following multiple stepwise regression (β = −17.071, P = 0.037). These results suggest that leptin methylation and mRNA expression might contribute to the pathogenesis of schizophrenia. LEP-CpG7 methylation may be negatively associated with positive symptoms in patients with schizophrenia.

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Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia

Cited by 16 publications

References 37 publications

Do Leptin Play a Role in Metabolism–Related Psychopathological Symptoms?

Do Leptin Play a Role in Metabolism–Related Psychopathological Symptoms?

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

Leptin Methylation and mRNA Expression Associated With Psychopathology in Schizophrenia Inpatients

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