Increased peripheral circulating inflammatory cells and plasma inflammatory markers in patients with variant angina

Li, Jianjun; Zhang, Yuping; Yang, Ping; Zeng, Hesong; Qian, Xuewen; Zhang, Chaoyang; Zhu, Chen-Gang; Li, Jie; Nan, Jin-Long

doi:10.1097/mca.0b013e3282fd5c4e

Cited by 17 publications

(11 citation statements)

References 25 publications

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“…These findings were consistent with the hypothesis that endothelial dysfunction in this setting may be attributable to a state of systemic inflammation. Recently clinical reports also suggested that systemic inflammatory activity is increased in patients with VA [23][24][25][26]. In our study, the levels of WBC and monocyte cell counts were significantly higher in patients of the VA group than in the other two groups.…”

Section: Figuresupporting

confidence: 58%

Endothelial dysfunction, increased carotid artery intima-media thickness and pulse wave velocity, and increased level of inflammatory markers are associated with variant angina

Cho

Jeong

Park

et al. 2009

Journal of Cardiology

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Section: Figuresupporting

confidence: 58%

Endothelial dysfunction, increased carotid artery intima-media thickness and pulse wave velocity, and increased level of inflammatory markers are associated with variant angina

Cho

Jeong

Park

et al. 2009

Journal of Cardiology

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“…A recent study by Hung et al, (2006) [91] has further shown that IL-6 levels were independently associated with the diagnosis of coronary vasospastic angina pectoris in the absence of advanced CAD supporting the hypothesis that coronary vasospasm at least in part represent an inflammatory condition. In addition, Li et al [92] recently reported that patients with variant angina display higher white blood cell and monocyte cell counts. Similarly, plasma IL-6 and CRP levels in that study were higher in variant angina patients compared with those patients with stable CAD.…”

Section: Vasospasm and Myocardial Infarctionmentioning

confidence: 99%

Cardiovascular Biology of Interleukin-6

Abeywardena

Leifert²,

Warnes³

et al. 2009

CPD

104

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Interleukin-6 (IL-6) is a multifunctional pro-inflammatory cytokine that is tightly regulated and expressed at low levels in healthy individuals. Increased IL-6 expression has been associated with a variety of diseases, including inflammatory conditions such as atherosclerosis and cardiovascular disease (obesity, myocardial infarction and type II diabetes). Cytokines including IL-6 and tumour necrosis factor alpha as well as acute phase proteins such as C-reactive protein (CRP) and fibrinogen are key biochemical risk factors for the development of these disease conditions. IL-6 is the key cytokine responsible for the stimulus of synthesis and secretion of CRP. IL-6 activates cell surface signalling via the assembly of IL-6, the IL-6 receptor (IL-6R) and the signalling receptor gp130. Assembly of the (hexameric) signalling complex of IL-6, IL-6R and gp130 occurs in a sequential manner and therefore this signalling complex lends itself to several potential sites for drug targeting. This review discusses some of the mechanisms of IL-6 signalling on various aspects of cardiovascular biology as well as some recent developments in drug targeting of this complex.

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“…Additionally, a recent study has suggested a strong association between circulating IL-6 levels and CHD risk in two population-based cohort studies along with a systematic review [41]. Another study showed that plasma IL-6 and CRP levels were higher in variant angina patients compared with those patients with stable CAD [42]. Similarly, significantly elevated circulating plasma levels of IL-6 and IL-6R (α and β) have been observed in patients with acute myocardial infarction.…”

Section: Interleukin-6mentioning

confidence: 94%

Update on the Role of Adipokines in Atherosclerosis and Cardiovascular Diseases

Lim

Hivert

2011

Curr Cardiovasc Risk Rep

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Adipose tissue is now considered an active hormone-secreting organ that produces a number of biologically active proteins called adipokines. "Classic" adipokines were discovered more than a decade ago; leptin was initially described as a satiety signal limiting food intake in animal models, whereas adiponectin is suspected to play a role in promoting insulin sensitivity. As adiposity increases, macrophages may infiltrate the adipose tissue. These macrophages are a source of many cytokines (tumor necrosis factor-α, interleukin-6, resistin, retinol binding protein-4) that are suspected to participate in low-grade proinflammatory processes leading to metabolic disorders, insulin resistance, and cardiovascular diseases. New adipokines, such as visfatin, vaspin and apelin, have recently been discovered but their exact roles are still unknown. This review focuses on recent updates regarding the contribution of adipokines in atherosclerosis or cardiovascular diseases.

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Increased peripheral circulating inflammatory cells and plasma inflammatory markers in patients with variant angina

Abstract: Taken together, these findings suggested that more chronic, severe inflammation might be involved in the pathogenesis of VA, manifested by increased counts of circulating inflammatory cells and elevated plasma levels of CRP and IL-6.

Cited by 17 publications

References 25 publications

Endothelial dysfunction, increased carotid artery intima-media thickness and pulse wave velocity, and increased level of inflammatory markers are associated with variant angina

Endothelial dysfunction, increased carotid artery intima-media thickness and pulse wave velocity, and increased level of inflammatory markers are associated with variant angina

Cardiovascular Biology of Interleukin-6

Update on the Role of Adipokines in Atherosclerosis and Cardiovascular Diseases

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