Endothelial dysfunction, increased carotid artery intima-media thickness and pulse wave velocity, and increased level of inflammatory markers are associated with variant angina

Cho, Sook Hee; Jeong, Myung Ho; Park, In Hyae; Choi, Jong Soo; Yoon, Hyun Ju; Kim, Kye Hun; Hong, Young Joon; Park, Hyung Wook; Kim, Ju Han; Ahn, Youngkeun; Cho, Jeong Gwan; Park, Jong Chun; Kang, Jung Chaee

doi:10.1016/j.jjcc.2009.05.003

Cited by 22 publications

(18 citation statements)

References 35 publications

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“…These patients had higher hs-CRP serum levels, increased mean common CIMT, and increased arterial stiffness [34]. In another study, endothelial dysfunction was associated with increased CIMT and PWV [35].…”

Section: Discussionmentioning

confidence: 90%

Carotid and brachial artery intima-media thickness is related to coronary atherosclerotic burden and may also represent high cardiovascular risk in patients with normal coronary angiograms

et al. 2011

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Section: Discussionmentioning

confidence: 90%

Carotid and brachial artery intima-media thickness is related to coronary atherosclerotic burden and may also represent high cardiovascular risk in patients with normal coronary angiograms

et al. 2011

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“…Loss of adequate endothelial cell function is most widely quantified by assessing FMD and NMD. Previously, we reported that decreased FMD and increased carotid IMT and PWV were associated with CAD 18. In particular, the dilatory response to NTG is used as a measure of endothelium-independent vasodilation.…”

Section: Discussionmentioning

confidence: 99%

“…Our study was unable to explore this association. Previously, several clinical and hemodynamic studies using nitrate were published in Korea 18,26-29. However, the clinical impact and mechanisms are not exactly known.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Nitroglycerin-Induced Headache as a Negative Predictor of Coronary Atherosclerosis

et al. 2011

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The purpose of the present study was to clarify the possible relationship between nitroglycerin (NTG)-induced headache and both vascular functional and organic atherosclerosis. The study included 96 patients with NTG-induced headache (group I: 54.7±9.5 years, 52 males) and 204 patients without headache (group II: 58.1±9.1 years, 127 males) who suffered from new-onset chest pain. Flow-mediated dilation and nitroglycerin-mediated dilation were significantly greater in group I than in group II (8.8±4.1% vs. 7.1±3.5%, p=0.001, and 23.1±7.3% vs. 17.1±11.8%, p<0.001, respectively). The carotid intima-media thickness was significantly smaller in group I than in group II (0.55±0.15 mm vs. 0.67±0.22 mm, p=0.001). Heart-carotid pulse wave velocity was significantly lower in group I than in group II (784.5±160.1 m/s vs. 979.1±215.6 m/s, p=0.003). In the multiple regression analysis, the absence of NTG-induced headache was a predictor of coronary artery disease (CAD) (odds ratio: 17.89, 95% confidence interval: 7.89-40.02, p<0.001). NTG-induced headache developed more frequently in patients with normal coronary arteries or minimal CAD than in patients with obstructive CAD. The presence of NTG-induced headache might be helpful and provide additional information in evaluating patients with chest pain syndrome.

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“…Throughout the study, FMD was measured by the same skilled examiner, who used the same ultrasound apparatus and probe set. We have previously reported inter-study coefficient of variation (CV) of 9% for FMD measurements (Cho et al, 2009). …”

Section: Brachial Flow-mediated Artery Vasodilatationmentioning

confidence: 99%

“…These benefits attribute to its pleiotropy, including modulation of endothelial function, alleviation of arterial stiffness, and stabilization of plaque (Cho et al, 2009). Pitavastatin calcium has been described as a "super statin" with stronger low-density lipoprotein cholesterol (LDL-C)/ triglyceride (TG)-lowering and high-density lipoprotein (HDL)-elevating effects compared with other statins at the initial dose.…”

Section: Introductionmentioning

confidence: 99%

Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia

Zhao

Yan

et al. 2015

J. Zhejiang Univ. Sci. B

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Background: Statins have proven efficacy in inhibiting the onset and progress of atherosclerosis. The effectiveness of pitavastatin in reversing carotid atherosclerosis associated with hypercholesterolemia (HC) is unknown. Objectives: To explore the simultaneous effects of pitavastatin calcium on brachial arterial flow-mediated vasodilatation (FMD), carotid intima-media thickness (IMT), and arterial stiffness (β), three surrogate markers of atherosclerosis were studied in HC patients. Methods: A randomized, double-blind trial was performed with 40 HC subjects who fulfilled the inclusion/exclusion criteria. Patients were given pitavastatin calcium 1 mg/d (Group 1) or 2 mg/d (Group 2) for 8 weeks. There were 20 patients in each group, and 30 gender-and age-matched healthy subjects as controls were recruited. FMD of the brachial artery, carotid IMT, and arterial stiffness indicated by β were measured at baseline and at 8 weeks after starting pitavastatin calcium therapy using ultrasound techniques. Biochemical tests were also made on all subjects. Results: At baseline, higher total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), reduced FMD, and increased β and IMT were observed in HC patients (P<0.001 for all) compared with controls. After 8 weeks, TC was decreased by 20.59%/27.56% and LDL-C 30.92%/35.64%, respectively, in comparison to baseline groups; the HC groups had reduced β and improved endothelial function over the 8-week follow-up (P<0.05-0.001); nonetheless, no significant alterations of IMT were found (P>0.05). Significant negative interactions between TC/LDL and FMD (P<0.05-0.001), positive interactions between TC and IMT (P=0.003) and between TC/LDL and β (P<0.001-0.000) were found. Conclusions: Treatment with pitavastatin calcium exerted favorable effects on endothelial function and arterial stiffness. It also improved carotid atherosclerosis in patients with HC.

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Endothelial dysfunction, increased carotid artery intima-media thickness and pulse wave velocity, and increased level of inflammatory markers are associated with variant angina

Abstract: VA is associated with endothelial dysfunction and increased carotid IMT, baPWV, and inflammatory markers.

Cited by 22 publications

References 35 publications

Carotid and brachial artery intima-media thickness is related to coronary atherosclerotic burden and may also represent high cardiovascular risk in patients with normal coronary angiograms

Carotid and brachial artery intima-media thickness is related to coronary atherosclerotic burden and may also represent high cardiovascular risk in patients with normal coronary angiograms

Diagnostic Value of Nitroglycerin-Induced Headache as a Negative Predictor of Coronary Atherosclerosis

Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia

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