Increased percentage of T cells with the expression of CD127 and CD132 in hypertrophic adenoid in children with otitis media with effusion

Żelazowska-Rutkowska, Beata; Wysocka, Jolanta; Kasprzycka, Edwina; Skotnicka, Bożena

doi:10.1007/s00405-012-1977-8

Cited by 10 publications

(10 citation statements)

References 22 publications

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“…Nowadays, increasing evidence indicates that adenoid immune dysfunction may induce and even aggravate SOM, but the exact mechanism is still not well defined. [ 13 ] In this study, we aim to investigate the roles of Tfh in the pathogenesis of SOM combined with AH. Our study contributed to the early screening and treatment of SOM combined with AH.…”

Section: Introductionmentioning

confidence: 99%

Roles of T follicular helper cells in the pathogenesis of adenoidal hypertrophy combined with secretory otitis media

et al. 2018

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The aim of this study was to investigate the roles of T follicular helper (Tfh) cells in secretory otitis media (SOM) combined with adenoidal hypertrophy (AH).Patients with AH or AH combined with SOM admitted to the Yancheng No. 1 People's Hospital from December 2012 to December 2014 were included. Fourteen age-matched healthy individuals received physical examinations in the hospital served as control. The venous Tfh was determined using flow cytometry, and CD3 + CD4 + CXCR5 + T lymphocytes were defined as Tfh cells. Serum inflammatory factors including IL-8, IL-1b, IL-6, IL-10, TNF, IL-12p70, IL-21, and IgE were determined using commercial kits.Compared with the AH group, the number of CD4 + CXCR5 + T cells in peripheral blood of the AH combined with SOM group showed significant increase. Statistical differences were noticed in the number of the number of CD4 + CXCR5 + T cells in moderate and severe AH groups compared with that of the control group. Statistical differences were identified in the proportion of CD4 + CXCR5 + T cells in the adenoidal tissues between the AH combined with SOM group and AH group (P < .05). For the CD4 + CXCR5 + T cells in adenoidal tissues, no statistical differences were noticed between the moderate and severe AH groups (P > .05). The number of CD4 + CXCR5 + T cells was positively correlated to the serum IL-21. Nevertheless, no correlation was noticed between CD4 + CXCR5 + T cell and serum IL-8, IL-6, IL-10, and IgE.Tfh is involved in the AH combined with SOM in children. Besides, serum IL-21, IL-8, IL-6, IL-10, and IgE may be involved in the onset of SOM in children.

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Section: Introductionmentioning

confidence: 99%

Roles of T follicular helper cells in the pathogenesis of adenoidal hypertrophy combined with secretory otitis media

et al. 2018

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“…OX40, also known as CD134, is a member of the superfamily of TNF receptors; which belongs to the type I transmembrane protein. OX40 was initially found on activated CD4 + T cells ( 8 , 9 ), but subsequent studies reported that OX40 is also expressed on activated CD8 + T cells and neutrophils ( 8 , 10 ). OX40 expression levels on naive CD4 cells peaked 2–3 days after T-cell receptor (TCR) stimulation, and were downregulated 4–5 days after the initial TCR stimulation ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

“…It has previously been reported that although there were no significant differences in immunoglobulin levels, patients treated with allergen immunotherapy had lower numbers of FOXP3 + lymphocytes than patients that were not treated ( 16 ). The percentage of T lymphocyte with IL-7R (CD127 and CD132) increased in hypertrophic adenoid, which appeared to influence the number and function of lymphocytes in tonsils; and further influenced the course of chronic otitis media with effusion ( 10 ). The decline of memory T cells was considered a risk factor of chronic otitis media with effusion in adolescents ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

Characterization of the T-cell subpopulations in the granulation tissues of chronic suppurative otitis media

Wang¹,

Cheng²,

Xu³

2016

Biomedical Reports

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The present study aimed to investigate the potential involvement of specific T-cell subpopulations in granulation tissue formation in chronic suppurative otitis media (CSOM). Fifteen patients with CSOM were enrolled in this study. Granulation tissues were obtained from the middle ear cavity. Hematoxylin and eosin staining was performed for histopathological observation, and different T-cell subpopulations were characterized by immunohistochemistry. No evident association was identified between granulation tissue formation and disease course. The number of cluster of differentiation 8+ (CD8+) T cells, forkhead box P3+ (FOXP3+) regulatory T (Treg) cells and OX40+ T cells were significantly higher in granulation tissues from patients with ear discharge within the last 6 months compared to those without (P<0.05). Fresh granulation tissues had more CD8+ T cells and FOXP3+ Treg cells compared to the mature granulation tissues (P<0.05). There was a differential abundance of specific T-cell subpopulations in the granulation tissues in CSOM with different disease courses or with ear discharge, suggesting that T cell-mediated cellular immunity is involved in lesion formation of CSOM.

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“…IL-7 plays a pivotal role for activation and proliferation of T and B cells, with IL-7R (CD127 and CD132) expression an important marker of immunologic function. Evaluation of CD4 1 and CD8 1 T cells in AH of older children suffering with OME for 3 months or without OME 74 found that the percentages of CD4 1 and CD8 1 CD127 receptor and CD4 1 CD132 expression but not CD8…”

Section: Adaptive Immunitymentioning

confidence: 99%

Panel 5: Immunology

Kyd

Hotomi

Kono

et al. 2017

Otolaryngol.--head neck surg.

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Objective. To perform a state-of-the-art review of the literature from January 2012 through May 2015 on studies that advanced our knowledge of the innate and adaptive immunology related to otitis media. This review also proposes future directions for research in this area.Data Sources. PubMed database of the National Library of Medicine.Review Methods. Three subpanels comprising experts in the field focused on sections relevant to cytokines, innate immunity, and adaptive immunity. The review focused on animal, cell line, and human studies and was critical in relation to the recommendations from the previous publication and for determination of the proposed goals and priorities. The panel met at the 18th International Symposium on Recent Advances in Otitis Media in June 2015 to consolidate its prior search results and discuss, plan, and refine the review. The panel approved the final draft.Conclusion. From 2012 to 2014, tremendous progresses in immunology of otitis media were established-especially in the areas of innate immunity associated with the pathogenesis of otitis media.Implications for Practice. The advances of the past 4 years formed the basis for a series of short-and long-term research goals in an effort to guide the field. Accomplishing these goals will provide opportunities for the development of novel interventions, including new ways to better treat and prevent otitis media, especially for recurrent otitis media.

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Increased percentage of T cells with the expression of CD127 and CD132 in hypertrophic adenoid in children with otitis media with effusion

Cited by 10 publications

References 22 publications

Roles of T follicular helper cells in the pathogenesis of adenoidal hypertrophy combined with secretory otitis media

Roles of T follicular helper cells in the pathogenesis of adenoidal hypertrophy combined with secretory otitis media

Characterization of the T-cell subpopulations in the granulation tissues of chronic suppurative otitis media

Panel 5: Immunology

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