Increased oxidized low density lipoprotein associated with high ceruloplasmin activity in patients with active acromegaly

Abstract

The increase in plasma oxLDL levels, a direct marker of the plaque formation, could constitute a link between atherosclerosis and active acromegaly. LDL oxidation would not be the consequence of diminished antioxidant defences, but of an enhancement in prooxidant factors like ceruloplasmin.

The assessment of total antioxidant capacity and superoxide dismutase levels, and the possible role of manganese superoxide dismutase polymorphism in acromegaly

“…Boero et al revealed that acromegaly could increase oxidative stress through increasing oxidized low density lipoprotein and activity of ceruloplasmin, despite the fact that they observed no significant difference in the ceruloplasmin levels, myeloperoxidase activity and TBARS as an index of lipid peroxidation [7]. In that study, no significant difference was found in the total antioxidant capacity between active acromegaly patients and controls, although TAC levels were decreased in acromegaly patients.…”

“…Acromegaly was attributed to oxidative stress through the mechanisms of decreased nitric oxide, catalase, oxidized glutathione and increased thiobarbituric acid reactive substance (TBARS) levels [6]. Also, high ceruloplasmin activity was associated with increased oxidized low-density lipoprotein in patients with active acromegaly [7]. However, the status of oxidative stress regarding the effect of disease activity is lacking.…”

GH levels and insulin sensitivity are differently associated with biomarkers of cardiovascular disease in active acromegaly

“…The variables selected for the sample size calculation were triglycerides, apo B, insulin, ox‐LDL, endothelin‐1 and CETP activity. Having defined a significance level of 0·05, 80% power and an effect size of 1·0, supported by our previous studies, the power analysis revealed that the sample size should not be lower than 22 patients and controls.…”

“…The increase in ox‐LDL levels has been already reported in patients with acromegaly, and we now report that this increase is independently predicted by GH concentration. In the literature, there is weak support for GH to stimulate oxidative stress directly.…”

Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans

“…Further, increases in serum TBARS levels and 8-OHdG levels were detected in patients with active acromegaly. Previously, it was reported that plasma oxidized low density lipoprotein (oxLDL) was increased in patients with acromegaly [24]. In animal models, carotid arteries from bGH TG mice had an impaired ACh-induced relaxation response and the endothelial dysfunction was corrected by addition of MnTBAP in carotid arteries, suggesting an involvement of ROS in the vascular dysfunction in bGH TG mice [25].…”