Increased Occurrence of Disorders of Sex Development, Prematurity and Intrauterine Growth Restriction in Children with Proximal Hypospadias Associated with Undescended Testes

Sekaran, Prabhu; O’Toole, Stuart; Flett, Martyn; Cascio, Salvatore

doi:10.1016/j.juro.2012.11.047

Cited by 25 publications

(7 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All were operated at a later age. So, these male cases are rare, and our findings roughly are in accordance with Scottish data [Sekaran et al, 2013]. Cryptorchidism is associated with other abnormalities in less than 20% of cases [Hutson et al, 2016b;Osterballe et al, 2017].…”

Section: Neonatal Periodsupporting

confidence: 92%

Surgical Management of Undescended Testis - Timetable and Outcome: A Debate

Thorup

Cortes

2019

Sex Dev

View full text Add to dashboard Cite

Around 1.4-3.8% of boys in the Western world are operated because of cryptorchidism. This means that orchidopexy remains one of the most common surgical procedures performed in boys. As a consequence, several consensus reports, guidelines, and reviews dealing with the management of cryptorchidism have been published recently. Based on our research and 30 years' experience with the management of cryptorchidism, the intention of the present publication is to advise on the surgical management and comment on the expected outcome, especially with focus on the controversies related to guidelines and reviews. Except for late referral and waiting lists, which may be practical problems, there is no reason to postpone orchidopexy for nonsyndromic congenital cryptorchid testes beyond 6 months. There is good evidence that such strategy improves the fertility potential and decreases the risk of testicular cancer. In cases with genuine gonadotropin insufficiency, early surgical correction is not enough and adjuvant LH-RH treatment should be implemented to improve the fertility potential. Cryopreservation may be an option in case of treatment failure of adjuvant LH-RH. A prerequisite for such management includes serum hormone assessment and evaluation of testicular biopsies at orchidopexy. Ascended testes contribute to 20-60% of operative cases and should be treated when diagnosed.

show abstract

Section: Neonatal Periodsupporting

confidence: 92%

Surgical Management of Undescended Testis - Timetable and Outcome: A Debate

Thorup

Cortes

2019

Sex Dev

View full text Add to dashboard Cite

show abstract

“…A recent analysis of the International Disorders of Sex Development (I-DSD) registry found that as many as 23 percent of patients with male DSD also had SGA [ 52 ]. Patients with more severe anomalies, including hypospadias and undescended testes, have higher rates of IUGR than those with less severe anomalies, such as hypospadias and descended testes [ 53 ]. Birth weights and/or lengths are lower in patients with an unknown cause for DSD than in patients with identified causes for DSD, suggesting that growth retardation, particularly early in gestation, may be associated with abnormal testicular differentiation or DSD [ 54 , 55 ].…”

Section: Resultsmentioning

confidence: 99%

Intrauterine growth restriction and hypospadias: is there a connection?

Chen

Macias

Gunn

et al. 2014

Int J Pediatr Endocrinol

View full text Add to dashboard Cite

Hypospadias is one of the most common congenital malformations of the genitourinary tract in males. It is an incomplete fusion of urethral folds early in fetal development and may be associated with other malformations of the genital tract. The etiology is poorly understood and may be hormonal, genetic, or environmental, but most often is idiopathic or multifactorial. Among many possible risk factors identified, of particular importance is low birth weight, which is defined in various ways in the literature. No mechanism has been identified for the association of low birth weight and hypospadias, but some authors propose placental insufficiency as a common inciting factor. Currently, there is no standardized approach for evaluating children with hypospadias in the setting of intrauterine growth restriction. We reviewed the available published literature on the association of hypospadias and growth restriction to determine whether it should be considered a separate entity within the category of disorders of sexual differentiation.

show abstract

“…Embryonal hormonal disorders associated with androgens are thought to lead to abnormal differentiation in primordial germ cells and gonocytes (25). Based on this hypothesis, disorders in androgen production and receptor expression and exposure to anti-androgenic or estrogenic effects have been shown to negatively affect genitourinary system development in animal experiments (26,27).…”

Section: Discussionmentioning

confidence: 99%

Additional Preoperative Parameters to Enable the Decision of Partial Orchiectomy in Small Testicular Masses

Selvi¹,

Başar²

2020

Bezmialem Science

View full text Add to dashboard Cite

Amaç:Tek taraflı, küçük (≤2 cm) testiküler kitlelerin preoperatif değerlendirmesinde, benign-malign ayrımını yapabilmede kullanılabilecek ek klinik parametrelerin öngörü değerini araştırarak, parsiyel orşiektomi uygulanabilecek hastaları belirlemeyi amaçladık.Yöntemler: Ocak 2010-Aralık 2017 tarihleri arasında radikal orşiektomi yapılan tek taraflı, küçük testiküler kitleye sahip 31 hastanın verileri retrospektif olarak incelendi. Hastaların demografik verileri, histopatolojik tümör tipleri, serum tümör belirteçleri, nötrofil/lenfosit oranı (NLR), monosit/lenfosit oranı (MLR), platelet/lenfosit oranı (PLO), ortalama platelet hacmi (MPV), eritrosit dağılım genişliği (RDW), testiküler disgenezis sendromu (TDS) ve bileşenlerinin varlığı, postoperatif takip verileri kaydedildi. Hastalar tümör histopatolojisine göre benign ve malign olarak iki gruba ayrılarak karşılaştırıldı.Bulgular: Ortalama tanı yaşı 29,39±5,90 olan 31 hastanın 11'i benign, 20'si malign patolojiye sahipti. İki grup arasında AFP (p=0,116), β-hCG (p=0,205), LDH (p=0,606), MPV (p=0,087) ve RDW (p=0,266) açısından anlamlı fark görülmezken; malign grupta MLR (p=0,001), NLR (p=0,036) ve PLR (p=0,001) anlamlı olarak daha yüksekti. Testiküler mikrolitiazis (p=0,719), inmemiş testis (p=0,254), hipospadias (p=0,645), atrofik testis (p=0,409) saptanma oranları gruplar arasında farklılık göstermezken; semen parametresi bozukluğu oranı (p=0,043) ve TDS varlığı (p=0,043) malign olgularda belirgin olarak yüksek bulundu. Çok değişkenli Objective: We aimed to determine the predictive value of additional parameters for differentiating benign-malign tumors and to identify optimal patients for partial orchiectomy in unilateral, small (≤2 cm) testicular masses. Methods:The data of 31 patients who underwent radical orchiectomy between January 2010 and December 2017 due to unilateral and small testicular masses were retrospectively analyzed. Demographic data, histopathological tumor types, serum tumor markers, neutrophil/lymphocyte ratio (NLR), monocyte/ lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV), red cell distribution width (RDW), the presence of testicular dysgenesis syndrome (TDS) and its components, postoperative follow-up outcomes were recorded. Patients were divided into two groups as benign and malignant.Results: There was no significant difference between groups in terms of AFP (p=0.116), β-hCG (p=0.205), LDH (p=0.606), MPV (p=0.087) and RDW (p=0.266); while MLR (p=0.001), NLR (p=0.036) and PLR (p=0.001) were significantly higher in malignant group. The presences of testicular microlithiasis (p=0.719), undescended testis (p=0.254), hypospadias (p=0.645), atrophic testis (p=0.409) were not different between groups; while the rate of disorders of semen parameters (p=0.043) and presence of TDS (p=0.043) were significantly higher in malignant cases.

show abstract

Increased Occurrence of Disorders of Sex Development, Prematurity and Intrauterine Growth Restriction in Children with Proximal Hypospadias Associated with Undescended Testes

Abstract: Prematurity and intrauterine growth restriction are significantly associated with proximal hypospadias and undescended testis. Also, due to the 28% incidence of an underlying sexual development disorder, male infants with proximal hypospadias should undergo multidisciplinary evaluation.

Cited by 25 publications

References 18 publications

Surgical Management of Undescended Testis - Timetable and Outcome: A Debate

Surgical Management of Undescended Testis - Timetable and Outcome: A Debate

Intrauterine growth restriction and hypospadias: is there a connection?

Additional Preoperative Parameters to Enable the Decision of Partial Orchiectomy in Small Testicular Masses

Contact Info

Product

Resources

About