Increased number and activation of colonic macrophages in pediatric patients with untreated Crohnʼs disease

Perminow, Gøri; Reikvam, Dag Henrik; Lyckander, Lars Gustav; Brandtzæg, Per; Vatn, Morten H.; Carlsen, Hege S.

doi:10.1002/ibd.20916

Cited by 18 publications

(16 citation statements)

References 262 publications

(387 reference statements)

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“…In contrast, the count of CD40+ in the colon of CD children was markedly elevated, compared to the controls. Moreover, the CD children showed a tendency for a higher density of CD40+ cells in the colon, compared to UC patients (mean rank 10.7 vs. 8.7) [28].…”

Section: Discussionmentioning

confidence: 89%

Evaluation of CD40 and CD80 receptors in the colonic mucosal membrane of children with inflammatory bowel disease

Kamińska

Roszko-Kirpsza

Landowski

et al. 2015

Ann Agric Environ Med.

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Introduction. The most prevalent inflammatory bowel diseases (IBD) include ulcerative colitis (UC) and Crohn's disease (CD). Immune processes play a vital role in the etiopathogenesis of these conditions, involving both cellular and humoral response mechanisms. The aim of this study was to quantify CD40-and CD80-positive cells in the biopsy specimens of large intestinal mucosa from children with IBD. Materials and method. The study comprised 38 children aged between 3-17 years (mean 11.5±3.7 years) -20 boys (52.6%) and 18 girls (47.4%). Eighteen patients were diagnosed with UC on the basis of clinical manifestation, endoscopic and histopathological findings. Mean age of this subgroup was 11.55±4.07 years. A group of 10 children (mean age 12.30±2.83) diagnosed with CD was also included. The control group comprised 10 IBD-free children (mean age 10.28±4.07 years). The surface expressions of CD40 and CD80 were analyzed in large intestine mucosa biopsy specimens, fixed in formaldehyde, embedded in paraffin, and cut with a microtome into 4 µm slices. Results. The number of CD40-and CD80-positive cells in the large intestinal mucosa of children with Crohn's disease and ulcerative colitis was significantly higher than in the controls. The highest number of CD40+ and CD80+ cells was observed in the caecal mucosal membrane of Crohn's disease patients and in the rectal mucosa of individuals with ulcerative colitis. Conclusion. IBD is characterized by elevated, segment-specific, expression of CD40 and CD80.

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Section: Discussionmentioning

confidence: 89%

Evaluation of CD40 and CD80 receptors in the colonic mucosal membrane of children with inflammatory bowel disease

Kamińska

Roszko-Kirpsza

Landowski

et al. 2015

Ann Agric Environ Med.

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“…A rapid early progression was reported in CD, with about one third of patients demonstrating complicated disease at diagnosis, including proximal disease [11], and with about two thirds showing complicated disease at the seventh year of follow-up [11]. A different immunologic expression during childhood, on the basis of a genetically transformed innate immune system, may explain the different clinical phenotypes among adults and children with IBD [47]. An interesting shift from male to female predominance around the age of puberty is unclear.…”

Section: Pediatric Problemsmentioning

confidence: 94%

Natural history and complications of IBD

Vatn

2009

Curr Gastroenterol Rep

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Inflammatory bowel diseases (IBD), mainly ulcerative colitis and Crohn's disease, are chronic, heterogenic, lifelong illnesses with young age of onset and a great potential for disability. The natural history of these diseases is influenced by multiple factors of environmental and genetic origin. Multidisciplinary research has increased our knowledge of the mechanisms involved during the development and outcome of the diseases, including disease complications. Immunomodulatory treatment has demonstrated greatly improved efficacy in moderate to severe disease activity. The long-term effect on the natural course of disease and sustained reduced burden on society over many years require study. This article summarizes recent knowledge on factors influencing the natural history of IBD, including the impact of treatment. Increased understanding of disease mechanisms is needed as a basis for new treatment strategies in the future.

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“…Indeed, causes underlying this disease are likely multifactorial. In general, studies have shown an increase in both DC and macrophage populations in the intestinal lamina propria in Crohn's Disease patients [20,32,33,[50][51][52]. Studies have also consistently shown that DCs in Crohn's Disease are more activated and have higher expression of microbial recognition receptors, particularly TLR4 [8,27,50,53,54].…”

Section: Phagocyte Subsets In the Intestine Of Patients With Crohn's mentioning

confidence: 98%

Intestinal dendritic cell and macrophage subsets: Tipping the balance to Crohn's Disease?

Magnusson

Wick

2011

European Journal of Microbiology and Immunology

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Increased number and activation of colonic macrophages in pediatric patients with untreated Crohnʼs disease

Cited by 18 publications

References 262 publications

Evaluation of CD40 and CD80 receptors in the colonic mucosal membrane of children with inflammatory bowel disease

Evaluation of CD40 and CD80 receptors in the colonic mucosal membrane of children with inflammatory bowel disease

Natural history and complications of IBD

Intestinal dendritic cell and macrophage subsets: Tipping the balance to Crohn's Disease?

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