Increased noise trauma in guinea pigs through magnesium deficiency

Ising, H; Handrock, M.; Günther, Th.; Fischer, R; Dombrowski, M.

doi:10.1007/bf00454034

Cited by 29 publications

(24 citation statements)

References 3 publications

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“…Perilymphatic Mg levels have been assumed to play an important role in acoustic trauma [3,11,17,20,30]. However, data previously reported are insufficient to support this hypothesis.…”

Section: Introductioncontrasting

confidence: 47%

“…Experimentally induced magnesium (Mg) deficiency has been found to increase noise-induced hearing loss in guinea pigs [7,12,16,17,23] and rats [16,20]. These findings also indicate that Mg as a dietary supplement might reduce auditory susceptibility to noise.…”

Section: Introductionmentioning

confidence: 56%

“…Handrock et al [12] and Ising et al [17] were the first investigators to demonstrate that severe Mg deficiency significantly increases noise-induced hearing loss when compared to animals having normal Mg levels. However, no correlation was found between the hearing loss as found and serum Mg levels which were in part considerably increased by stress [17].…”

Section: Discussionmentioning

confidence: 99%

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Preventive effect of magnesium supplement on noise-induced hearing loss in the guinea pig

Scheibe

Haupt

Ising

2000

European Archives of Oto-Rhino-Laryngology

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The effect of magnesium (Mg) on noise-induced hearing loss was investigated in two groups of adult pigmented guinea pigs maintained either on optimal or suboptimal (physiologically high or low) Mg produced by different diets. The total Mg concentrations of the perilymph (PL), cerebrospinal fluid, blood plasma and red blood cells were measured by atomic absorption spectrometry and were found to differ significantly between the two groups (P < 0.01). One ear of each animal was exposed to either a single shooting impulse at a peak pressure level of 187 dB or two impulse noise series at a rate of 1/s and peak pressure levels of 150 dB (1,000 impulses) and 167 dB (2,280 impulses), respectively. Temporary (TTS) and permanent (PTS) hearing threshold shifts in anesthetized animals were measured 2 h and 1 week after the noise exposure, using auditory brain stem response (ABR) audiometry at a frequency range from 3.75 to 30 kHz. Exposure to the single noise impulse resulted in a mean TTS that was significantly lower in the high Mg group than that in the low Mg group (P < 0.05), although no substantial PTS was observed in either group. In the animals exposed to 150 dB noise, the TTS showed a tendency towards an Mg-related reduction at the higher frequencies. A small difference in PTS was found between the low Mg and high Mg groups, but was not significant. Exposure to the 167-dB noise series caused a considerable TTS, which was significantly lower in the high Mg group at 7.5 and 15 kHz than in the low Mg group (P < 0.05). The mean PTS showed a significant difference between the two Mg groups over the whole frequency range (P < 0.05) and was found to correlate negatively with the total Mg concentrations of both PL and plasma (P < 0.05). Moreover, the high Mg group showed a faster recovery from the hearing threshold shift than the low Mg group. The present findings show that preventive oral Mg supplements can significantly reduce the rate of acoustic trauma caused by high-level impulse noise exposure in the guinea pig.

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“…Perilymphatic Mg levels have been assumed to play an important role in acoustic trauma [3,11,17,20,30]. However, data previously reported are insufficient to support this hypothesis.…”

Section: Introductioncontrasting

confidence: 47%

Section: Introductionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

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Preventive effect of magnesium supplement on noise-induced hearing loss in the guinea pig

Scheibe

Haupt

Ising

2000

European Archives of Oto-Rhino-Laryngology

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“…As a consequence of its effects on blood flow, other biochemical mechanisms (described below), or some combination of effects, magnesium supplements protect against NIHL in humans (Joachims et al, 1993;Attias et al, 1994;2004), guinea pigs (Scheibe et al, 2000;Haupt and Scheibe, 2002;Scheibe et al, 2002;Attias et al, 2003;Haupt et al, 2003), and rats (Joachims et al, 1983). In contrast, magnesium deficient diets increase susceptibility to NIHL in rats (Joachims et al, 1983) and guinea pigs (Ising et al, 1982;Scheibe et al, 2000). In addition to the well characterized effects on vasodilation, biochemical effects of magnesium include modulation of calcium channel permeability, influx of calcium into cochlear hair cells, and glutamate release (Gunther et al, 1989;Cevette et al, 2003).…”

Section: Vasodilation and Nihlmentioning

confidence: 99%

Mechanisms of noise-induced hearing loss indicate multiple methods of prevention

et al. 2007

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Recent research has shown the essential role of reduced blood flow and free radical formation in the cochlea in noise-induced hearing loss (NIHL). The amount, distribution, and time course of free radical formation have been defined, including a clinically significant late formation 7-10 days following noise exposure, and one mechanism underlying noise-induced reduction in cochlear blood flow has finally been identified. These new insights have led to the formulation of new hypotheses regarding the molecular mechanisms of NIHL; and, from these, we have identified interventions that prevent NIHL, even with treatment onset delayed up to 3 days post-noise. It is essential to now assess the additive effects of agents intervening at different points in the cell death pathway to optimize treatment efficacy. Finding safe and effective interventions that attenuate NIHL will provide a compelling scientific rationale to justify human trials to eliminate this single major cause of acquired hearing loss.

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“…A recent investigation with the natural calcium antago nist magnesium showed a significant decrease in noiseinduced hearing loss in soldiers exposed to gun fire [22], In guinea pigs, a reduced perilymphatic concentration of magnesium was correlated with inner ear hearing dys function [23]. The first trial to treat sudden hearing loss with the calcium channel blocker nimodipine was re ported in 1980, but two subsequent studies have failed to show a positive influence on hearing loss when utilizing calcium antagonist drugs [24][25][26], Histopathologic devel opment of noise trauma and sudden hearing loss are com bined with metabolic damage to the cells of the cochlea, including an intracellular calcium overload [27], Myocar dial cells are known to be less sensitive to ischemic insult in the presence of a sufficient concentration of calcium channel blockers, preventing an elevated calcium influx during reperfusion.…”

Section: Discussionmentioning

confidence: 99%

Diltiazem for Prevention of Acoustical Trauma during Otologic Surgery

Maurer¹,

Riechelmann²,

Amedee

et al. 1995

ORL

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100 patients were tested in a prospective, randomized, double-blinded study to assess the perioperative efficacy of a calcium channel blocker (diltiazem) in preventing acoustical trauma during otologic surgery. The patients were randomly divided into a therapy group (diltiazem) and a control group (placebo). Bone conduction hearing thresholds were examined preoperatively and again 1 day and 3 months postoperatively. Frequency-dependent changes in postoperative bone conduction and the number of patients with various degrees of postoperative hearing loss in both groups were statistically analyzed. The results indicated only a small postoperative hearing loss after ear surgery in both groups. There was a tendency for better results in the therapy group, but this was not statistically significant. Despite favorable results in animal trials utilizing different types of noise and the prophylactic application of diltiazem, further studies in humans are needed to determine the role of calcium antagonist drugs in the prophylaxis or treatment of acoustical trauma.

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Increased noise trauma in guinea pigs through magnesium deficiency

Cited by 29 publications

References 3 publications

Preventive effect of magnesium supplement on noise-induced hearing loss in the guinea pig

Preventive effect of magnesium supplement on noise-induced hearing loss in the guinea pig

Mechanisms of noise-induced hearing loss indicate multiple methods of prevention

Diltiazem for Prevention of Acoustical Trauma during Otologic Surgery

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