Preventive effect of magnesium supplement on noise-induced hearing loss in the guinea pig

Scheibe, F.; Haupt, H.; Ising, H

doi:10.1007/pl00007505

Cited by 31 publications

(32 citation statements)

References 21 publications

(34 reference statements)

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“…Another agent that may reduce NIHL via protection against noise-induced decreases in cochlear blood flow and oxygenation is magnesium (Altura et al, 1992;Haupt and Scheibe, 2002). As a consequence of its effects on blood flow, other biochemical mechanisms (described below), or some combination of effects, magnesium supplements protect against NIHL in humans (Joachims et al, 1993;Attias et al, 1994;2004), guinea pigs (Scheibe et al, 2000;Haupt and Scheibe, 2002;Scheibe et al, 2002;Attias et al, 2003;Haupt et al, 2003), and rats (Joachims et al, 1983). In contrast, magnesium deficient diets increase susceptibility to NIHL in rats (Joachims et al, 1983) and guinea pigs (Ising et al, 1982;Scheibe et al, 2000).…”

Section: Vasodilation and Nihlmentioning

confidence: 99%

“…As a consequence of its effects on blood flow, other biochemical mechanisms (described below), or some combination of effects, magnesium supplements protect against NIHL in humans (Joachims et al, 1993;Attias et al, 1994;2004), guinea pigs (Scheibe et al, 2000;Haupt and Scheibe, 2002;Scheibe et al, 2002;Attias et al, 2003;Haupt et al, 2003), and rats (Joachims et al, 1983). In contrast, magnesium deficient diets increase susceptibility to NIHL in rats (Joachims et al, 1983) and guinea pigs (Ising et al, 1982;Scheibe et al, 2000). In addition to the well characterized effects on vasodilation, biochemical effects of magnesium include modulation of calcium channel permeability, influx of calcium into cochlear hair cells, and glutamate release (Gunther et al, 1989;Cevette et al, 2003).…”

Section: Vasodilation and Nihlmentioning

confidence: 99%

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Mechanisms of noise-induced hearing loss indicate multiple methods of prevention

et al. 2007

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Recent research has shown the essential role of reduced blood flow and free radical formation in the cochlea in noise-induced hearing loss (NIHL). The amount, distribution, and time course of free radical formation have been defined, including a clinically significant late formation 7-10 days following noise exposure, and one mechanism underlying noise-induced reduction in cochlear blood flow has finally been identified. These new insights have led to the formulation of new hypotheses regarding the molecular mechanisms of NIHL; and, from these, we have identified interventions that prevent NIHL, even with treatment onset delayed up to 3 days post-noise. It is essential to now assess the additive effects of agents intervening at different points in the cell death pathway to optimize treatment efficacy. Finding safe and effective interventions that attenuate NIHL will provide a compelling scientific rationale to justify human trials to eliminate this single major cause of acquired hearing loss.

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Section: Vasodilation and Nihlmentioning

confidence: 99%

Section: Vasodilation and Nihlmentioning

confidence: 99%

Mechanisms of noise-induced hearing loss indicate multiple methods of prevention

et al. 2007

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“…That exogenous antioxidant agents reduce sensory cell death and NIHL has been well demonstrated in animal studies using a variety of free radical scavengers [24,[44][45][46][47][48][49][50][51][52][53][54][55][56], including several studies with dietary antioxidants [50,[57][58][59][60]. Magnesium supplements also reduce NIHL [61][62][63][64][65][66][67][68][69].…”

mentioning

confidence: 99%

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Prell

Hughes

Miller

2007

Free Radical Biology and Medicine

198

188

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Free radical formation in the cochlea plays a key role in the development of noise-induced hearing loss (NIHL). The amount, distribution, and time course of free radical formation have been defined, including a clinically significant formation of both reactive oxygen species and reactive nitrogen species 7-10 days following noise exposure. Reduction in cochlear blood flow as a result of free radical formation has also been described. Here we report that the antioxidant agents, vitamins A, C, and E, act in synergy with magnesium to effectively prevent noise-induced trauma. Neither the antioxidant agents nor magnesium reliably reduced NIHL or sensory cell death with the doses we used when these agents were delivered alone. In combination, however, they were highly effective in reducing both hearing loss and cell death even with treatment initiated just one hour prior to noise exposure. This study supports roles for both free radical formation and noise-induced vasoconstriction in the onset and progression of NIHL. Identification of this safe and effective antioxidant intervention that attenuates NIHL provides a compelling rationale for human trials in which free radical scavengers are used to eliminate this single major cause of acquired hearing loss. Keywords cochlea; free radical; noise; hearing; antioxidant; vasodilation Mechanical destruction of cells in the organ of Corti was once assumed to be the primary cause of noise-induced hearing loss (NIHL) [1][2][3][4][5][6][7][8], with perhaps some effect of reduced blood flow to the inner ear [9][10][11][12][13][14][15][16][17][18]. We now know that another key factor is intense metabolic activity that results in production of excess free radicals [19][20][21][22][23] and lipid peroxidation products [24]. Noise-induced production of reactive oxygen species (ROS) in the cochlea has now been well characterized, and several recent reviews are available [25][26][27]. Mitochodrial dysfunction and ROS production have been implicated in numerous neurodegenerative syndromes and diseases [28-34, see 35,36]. The use of antioxidant agents holds significant therapeutic promise for many neurodegenerative processes [32,33,[37][38][39][40][41][42], and there is some suggestion that Correspondence to: C. G. Le Prell, Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506, USA. Tel: +1-734-763-5104; fax +1-734-764-0014. E-mail address: colleeng@umich.edu. Disclosure. Dr. Miller is a founding member and Chairman of the Board of Directors at OtoMedicine, Inc., a company that has an option to license the intellectual property described in this report. Dr. Le Prell is a paid consultant to OtoMedicine, Inc. Drs. Miller and Le Prell have disclosed these relationships to the Medical School Conflict of Interest Board at the University of Michigan; conflict management plans including semi-annual review by the Board are in place.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publicatio...

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“…Beta carotene was not been measured in detectable levels in plasma samples from guinea pigs and may not be available in the inner ear. In contrast, there is a clear relationship between dietary Mg and Mg levels measured in cochlear perilymph (Scheibe et al 1999(Scheibe et al , 2002Xiong et al 2013), with perilymph levels being significantly reduced relative to plasma levels. The increased plasma levels measured here are consistent with plasma levels measured in other studies, in which increased perilymph concentrations were also detected (Scheibe et al 2002).…”

Section: Figmentioning

confidence: 93%

Assessment of Nutrient Supplement to Reduce Gentamicin-Induced Ototoxicity

Prell

Ojano-Dirain

Rudnick

et al. 2014

JARO

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Gentamicin is an aminoglycoside antibiotic used to treat gram-negative bacterial infections. Treatment with this antibiotic carries the potential for adverse side effects, including ototoxicity and nephrotoxicity. Ototoxic effects are at least in part a consequence of oxidative stress, and various antioxidants have been used to attenuate gentamicin-induced hair cell death and hearing loss. Here, a combination of nutrients previously shown to reduce oxidative stress in the hair cells and attenuate hearing loss after other insults was evaluated for potential protection against gentamicin-induced ototoxicity. Guinea pigs were maintained on a nutritionally complete standard laboratory animal diet or a diet supplemented with β-carotene, vitamins C and E, and magnesium. Three diets with iterative increases in nutrient levels were screened; the final diet selected for study use was one that produced statistically reliable increases in plasma levels of vitamins C and E and magnesium. In two separate studies, significant decreases in gentamicin-induced hearing loss at frequencies including 12 kHz and below were observed, with less benefit at the higher frequencies. Consistent with the functional protection, robust protection of both the inner and outer hair cell populations was observed, with protection largely in the upper half of the cochlea. Protection was independently assessed in two different laboratories, using two different strains of guinea pigs. Additional in vitro tests did not reveal any decrease in antimicrobial activity with nutrient additives. Currently, there are no FDA-approved treatments for the prevention of gentamicin-induced ototoxicity. The current data provide a rationale for continued investigations regarding translation to human patients.

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Preventive effect of magnesium supplement on noise-induced hearing loss in the guinea pig

Cited by 31 publications

References 21 publications

Mechanisms of noise-induced hearing loss indicate multiple methods of prevention

Mechanisms of noise-induced hearing loss indicate multiple methods of prevention

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Assessment of Nutrient Supplement to Reduce Gentamicin-Induced Ototoxicity

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