Increased neutrophil priming and sensitization before commencing cardiopulmonary bypass in cardiac surgical patients

Gu, Yongquan; Schoen, Pieter; Tigchelaar, Izaak; Loef, Bart G; Ebels, Tjark; Rankin, A. H.; Oeveren, Willem van

doi:10.1016/s0003-4975(02)03822-5

Cited by 14 publications

(7 citation statements)

References 30 publications

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“…1 Gu et al reported neutrophil preactivation before the institution of cardiopulmonary bypass. 18 In addition, Chello et al mentioned amplification of inflammatory response by surgical stress in patients undergoing off-pump or on-pump surgery. 19 In our opinion, elevations in C-reactive protein levels are related to the surgical stress itself rather than the use of cardiopulmonary bypass.…”

Section: Discussionmentioning

confidence: 99%

“…Sternotomy is a highly traumatic access that causes a marked inflammatory response even before the institution of cardiopulmonary bypass 1 . Gu et al reported neutrophil preactivation before the institution of cardiopulmonary bypass 18 . In addition, Chello et al mentioned amplification of inflammatory response by surgical stress in patients undergoing off-pump or on-pump surgery 19 .…”

Section: Discussionmentioning

confidence: 99%

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Alterations in antioxidant and oxidant status of children after on-pump surgery for cyanotic and acyanotic congenital heart diseases

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Alterations in antioxidant and oxidant status of children after on-pump surgery for cyanotic and acyanotic congenital heart diseases

et al. 2016

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“…Indeed, Gu and colleagues demonstrated recently that dexamethasone 1 mg kg À1 did not stabilize neutrophils, and that priming and sensitization of neutrophils occurred before commencing CPB. 13 Yet the contribution of the inflammatory response to transient renal dysfunction during CPB is still unclear. It was suggested recently that leukodepletion during cardiac surgery with CPB may offer some renal protection, as demonstrated by Tang and colleagues.…”

Section: Discussionmentioning

confidence: 99%

Effect of dexamethasone on perioperative renal function impairment during cardiac surgery with cardiopulmonary bypass

Loef¹,

Henning²,

Epema³

et al. 2004

British Journal of Anaesthesia

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“…CPB induces a whole body inflammatory response that sometimes leads to postoperative organ dysfunction and neutrophil activation plays an important role in this reaction. Neutrophil activation is implicated in postoperative complications in patients having cardiac surgery with CPB ( 18 ). Leukocytosis was identified as an alarming sign for mortality among patients admitted to general hospital wards at early stages of admission ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Hematological Changes in Patients Undergoing Coronary Artery Bypass Surgery: a Prospective Study

Lako

Dedej

Nurka

et al. 2015

Med Arh

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Objectives:Removal of pro inflammatory stimuli after CABG, wound closure and the regenerative ability of the bone marrow will ensure a gradual recovery of hematological parameters. The aim of this study was to assess the hematological changes after CABG.Materials and Methods:A prospective cohort study included 164 consecutive patients undergoing on pump CABG surgery between January 2012 and January 2013. Patients with primary hematologic disease, emergent or urgent CABG and off-pump CABG were not included. A time line protocol was employed.Results:All patients survived surgery. Average values of erythrocytes, hemoglobin and hematocrit declined, to reach lower values on day 3 after surgery (-33.6 %, -33.1 %, -32.6 % versus preoperative value, p<0.001) and then gradually increased to reach normal values after one month and the preoperative values after three months. The average values of leukocytes and neutrophils increased rapidly to achieve the highest value on day 2, while the average value of lymphocytes decreased quickly to achieve lower value on day 1 after surgery (+74.7 %, +127.1 %, -52.4 % respectively from the preoperative value, p<0.001). The average platelet count decreased to the lowest value on day 2 after surgery (-26.4 % from the preoperative value, p<0.001), after which gradually increased up to +100.8 % of preoperative value on day 14 (p<0.001) and then gradually decreased to reach normal values on day 21 and preoperative values after three months.Conclusions:Average values of the three peripheral blood cells parameters undergo important changes after CABG, but not life threatening, and regain normal and preoperative values after 1-3 months after surgery.

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Increased neutrophil priming and sensitization before commencing cardiopulmonary bypass in cardiac surgical patients

Cited by 14 publications

References 30 publications

Alterations in antioxidant and oxidant status of children after on-pump surgery for cyanotic and acyanotic congenital heart diseases

Alterations in antioxidant and oxidant status of children after on-pump surgery for cyanotic and acyanotic congenital heart diseases

Effect of dexamethasone on perioperative renal function impairment during cardiac surgery with cardiopulmonary bypass

Hematological Changes in Patients Undergoing Coronary Artery Bypass Surgery: a Prospective Study

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