2016
DOI: 10.1017/s1047951116000573
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Abstract: There was no difference between oxidative stress status of cyanotic and acyanotic congenital heart disease patients and healthy individuals. Oxidative stress status of cyanotic and acyanotic patients does not change after cardiac surgery under cardiopulmonary bypass.

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Cited by 8 publications
(4 citation statements)
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“…All these data suggest that during surgery, changes in oxygenation, perfusion, hemodilution, and other variables related to oxidative status had a greater effect in patients with a pre-surgical cyanotic condition, particularly those with TGA. Our results contrast those of Altin et al who did not find any differences in OS between cyanotic and acyanotic patients following CPB surgery [ 19 ]. This discrepancy could be partially explained by patient population, as only 3 of the 30 patients in their cyanotic group had TGA anatomy.Patients who experienced intra-operative electrical seizures had significantly higher post-operative 8-iso-PGF2α levels than patients with no intra-operative seizure activity.…”
Section: Discussioncontrasting
confidence: 99%
“…All these data suggest that during surgery, changes in oxygenation, perfusion, hemodilution, and other variables related to oxidative status had a greater effect in patients with a pre-surgical cyanotic condition, particularly those with TGA. Our results contrast those of Altin et al who did not find any differences in OS between cyanotic and acyanotic patients following CPB surgery [ 19 ]. This discrepancy could be partially explained by patient population, as only 3 of the 30 patients in their cyanotic group had TGA anatomy.Patients who experienced intra-operative electrical seizures had significantly higher post-operative 8-iso-PGF2α levels than patients with no intra-operative seizure activity.…”
Section: Discussioncontrasting
confidence: 99%
“…The main finding of this study was that the blood levels of superoxide anion radical did not significantly differ between adults with CHD and their age- and gender-matched healthy controls. This finding is contrary to some other studies that claim the presence of oxidative stress in the peripheral blood of patients with CHD [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ], but it is in accordance with three studies showing that there was no significant difference in oxidative stress in the peripheral blood of patients with CHD and healthy individuals [ 46 , 47 , 48 ].…”
Section: Discussioncontrasting
confidence: 58%
“…In our study, only five adult patients with VSD were included; this subgroup was too small to perform a separate statistical analysis. In contrast, in most other studies on oxidative stress in the blood of patients with CHD, indirect nonspecific markers of oxidative stress [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ] were used, e.g., the assessment of the activity of oxidative and antioxidant enzymes (superoxide dismutase (SOD), catalase and glutathione peroxidase), levels of antioxidants (vitamin E, uric acid and selenium), levels of malondialdehyde (MDA) and protein carbonyl (PCO), plasma total oxidant status (TOS), total antioxidant capacity or status (TAC or TAS) and oxidative stress index (OSI) as well as the quantification of DNA damage assessed by alkaline comet assay in circulating lymphocytes and levels of 8-hydroxy-2′-deoxyguanosine.…”
Section: Discussionmentioning
confidence: 91%
“…Of the many indicators of oxidative stress we decided to use TBARS and TAS, which have been used in many trials aimed at assessing tissue trauma after surgery [22][23][24][25][26]. Results of studies comparing open and laparoscopic methods are greatly divergent, with some studies indicating less oxidative stress following laparoscopic surgery [27], others pointing to increased oxidative stress with laparoscopic surgery [8], and still others finding no differences in terms of oxidative stress between open and laparoscopic surgery [28].…”
Section: Discussionmentioning
confidence: 99%