Increased neutrophil lymphocyte ratio and platelet lymphocyte ratio in malignant parotid tumors

Kuzucu, İhsan; Güler, İsmail; Kum, Rauf Oğuzhan; Baklacı, Deniz; Özcan, Müge

doi:10.1016/j.bjorl.2019.02.009

Cited by 15 publications

(18 citation statements)

References 35 publications

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“…Kuzucu et al conducted a study in 145 patients undergoing parotidectomy and 83 healthy persons and found that elevated NLR was significantly higher in patients undergoing surgery for malignant parotid mass. 55 This supports the link between inflammation and cancer. Son et al performed a retrospective study in 369 patients and found that elevated NLR was significantly associated with increased risk of surgical site infection in patients with HNC undergoing major oncologic resection.…”

Section: Discussionsupporting

confidence: 60%

“…To date, only few articles describe the impact of elevated NLR in surgically treated patients with HNC. Kuzucu et al conducted a study in 145 patients undergoing parotidectomy and 83 healthy persons and found that elevated NLR was significantly higher in patients undergoing surgery for malignant parotid mass 55 . This supports the link between inflammation and cancer.…”

Section: Discussionmentioning

confidence: 89%

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Association of low skeletal muscle mass and systemic inflammation with surgical complications and survival after microvascular flap reconstruction in patients with head and neck cancer

et al. 2022

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Background: Skeletal muscle mass (SMM) and chronic inflammation are associated with postoperative complications and survival.Methods: Patients with head and neck cancer (HNC) undergoing microvascular free flap reconstruction were included. SMM and neutrophil-to-lymphocyte ratio (NLR) were measured and their association with treatment outcomes analyzed. Results: Five hundred and fifty-four patients were included. Predictors for complications were elevated NLR in all flaps (OR 1.5), low SMM in radial forearm flap (OR 2.0), and elevated NLR combined with low SMM in fibula flap surgery (OR 4.3). Patients with solely elevated NLR were at risk for flap-related complications (OR 3.0), severe complications (OR 2.2), and when combined with low SMM for increased length of hospital stays (LOS) (+3.9 days). In early-stage HNC, low SMM (HR 2.3), and combined elevated NLR with low SMM (HR 2.6) were prognostics for decreased overall survival.Conclusions: SMM and NLR are predictive for poor outcomes in patients with HNC undergoing microvascular reconstruction.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 89%

Association of low skeletal muscle mass and systemic inflammation with surgical complications and survival after microvascular flap reconstruction in patients with head and neck cancer

et al. 2022

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“…The composite inflammatory indicators such as monocyteto-high-density lipoprotein ratio (MHR) (15), neutrophilto-lymphocyte ratio (NLR) (15), systematic immuneinflammation index (SII) (16), and systemic inflammation response index (SIRI) (17) are a novel type of parameters based on the traditional peripheral blood cell count, calculated by combining different biochemical parameters to balance inflammation and immunity status (17). Previous studies have confirmed that these indicators could reflect inflammation levels and were widely used in evaluating the risk of various chronic diseases and the prognosis of tumors (18)(19)(20)(21)(22). Therefore, our study enrolled and screened these four simple-to-calculate and easily accessible systemic inflammatory indicators to assess their effect in evaluating the risk of metabolic diseases and CVD, filling the knowledge gap on the association between inflammation and metabolic diseases at the individual level.…”

Section: Introductionmentioning

confidence: 99%

Monocyte-to-high-density lipoprotein ratio and systemic inflammation response index are associated with the risk of metabolic disorders and cardiovascular diseases in general rural population

et al. 2022

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BackgroundThe present study aimed to clarify the effects of four inflammatory indicators (monocyte-to-high-density lipoprotein ratio [MHR], neutrophil-to-lymphocyte ratio [NLR], systematic immune-inflammation index [SII], and systemic inflammation response index [SIRI]) in evaluating the risk of metabolic diseases and cardiovascular disease (CVD), filling the gap of inflammation-metabolism system research in epidemiology.MethodsWe conducted a cross-sectional study and multivariable logistic regression analysis to elucidate the association between inflammatory indicators and metabolic diseases and CVD risk. Metabolic diseases were defined as metabolic disorders (MetDs) or their components, such as metabolic syndrome (MetS), dyslipidemia, and central obesity. We calculated the Framingham risk score (FRS) to evaluate 10-year CVD risk.ResultsOdds ratios for the third vs. the first tertile of MHR were 2.653 (95% confidence interval [CI], 2.142–3.286) for MetD, 2.091 (95% CI, 1.620–2.698) for MetS, 1.547 (95% CI, 1.287–1.859) for dyslipidemia, and 1.515 (95% CI, 1.389–1.652) for central obesity. Odds ratios for the third vs. the first tertile of SIRI were 2.092 (95% CI, 1.622–2.699) for MetD, 3.441 (95% CI, 2.917–4.058) for MetS, 1.417 (95% CI, 1.218–1.649) for dyslipidemia, and 2.080 (95% CI, 1.613–2.683) for central obesity. The odds ratio of a 10-year CVD risk of >30% for the third vs. the first tertile of MHR was 4.607 (95% CI, 2.648–8.017) and 3.397 (95% CI, 1.958–5.849) for SIRI.ConclusionsMHR and SIRI had a significant association with MetD and its components, in which a higher level of MHR or SIRI tended to accompany a higher risk of metabolic diseases. Furthermore, they also correlated with CVD, and the increment of these indicators caused a gradually evaluated risk of 10-year CVD risk.

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“…16 Damar ve ark., Cheng ve ark., Kawakita ve ark., Seng ve ark., ile Kuzucu ve ark.nın yaptıkları çalışmalarda, NLR ve PLR'yu malign lezyonlarda daha yüksek olarak saptanmıştır. 1,15,[17][18][19] Malign parotis tümörlü hastalarda, benign parotis tümörlü hastalara göre yüksek NLR, yüksek nötrofil yüzdesi, düşük lenfosit sayısı ve düşük lenfosit yüzdesi saptanmıştır. NLR ve lenfosit yüzdesi kombinasyonunun düşük ve yüksek gradeli tümörleri ayırt etmede bir belirteç olarak kullanılabileceği tespit edilmiştir.…”

Section: Bulgularunclassified

The Value of Inflammatory Parameters in the Differantial Diagnosis of “Benign” and “Malignant” Lesions in Parotid Gland Tumors

Özdemir¹,

Birinci²,

Bedir³

et al. 2019

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Increased neutrophil lymphocyte ratio and platelet lymphocyte ratio in malignant parotid tumors

Cited by 15 publications

References 35 publications

Association of low skeletal muscle mass and systemic inflammation with surgical complications and survival after microvascular flap reconstruction in patients with head and neck cancer

Association of low skeletal muscle mass and systemic inflammation with surgical complications and survival after microvascular flap reconstruction in patients with head and neck cancer

Monocyte-to-high-density lipoprotein ratio and systemic inflammation response index are associated with the risk of metabolic disorders and cardiovascular diseases in general rural population

The Value of Inflammatory Parameters in the Differantial Diagnosis of “Benign” and “Malignant” Lesions in Parotid Gland Tumors

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