Increased neural response related to neutral faces in individuals at risk for psychosis

Seiferth, Nina; Pauly, Katharina; Habel, Ute; Kellermann, Thilo; Shah, N. Jon; Ruhrmann, Stephan; Klosterkötter, Joachim; Schneider, Frank; Kircher, Tilo

doi:10.1016/j.neuroimage.2007.11.020

Cited by 129 publications

(110 citation statements)

References 50 publications

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“…These data do not support the assumption that deficits in processing of faces and their emotional content develop during and/or are a result of illness chronification and long-term medication. Further, the results are in line with evidence showing decreased activation of the fusiform gyrus associated with impaired face processing and social cognition in nonclinical samples, as subjects at risk for psychosis (Seiferth et al, 2008), and in other clinical samples with related behavioral impairments, such as autism patients (Schultz et al, 2003).…”

Section: Decreased Activation During Facial Emotion Processing In Juvsupporting

confidence: 87%

“…Thus, processing depth was associated with a decrease in processing speed in healthy juveniles but not in patients. Further, patients' sensitivity showed a negative correlation to fusiform activation on neutral faces, which was not observable in controls, underlining the importance of a changed processing of neutral faces in the course of schizophrenia, as it was recently reported for risk subjects (Seiferth et al, 2008).…”

Section: Decreased Activation During Facial Emotion Processing In Juvsupporting

confidence: 55%

“…Stimuli consisted of colored photographs of facesFbalanced with regard to age, sex, and ethnicityFshowing different emotional facial expressions (happy, sad, angry, fearful) or no emotion (neutral). The development and evaluation of the FEBA task has been reported in detail elsewhere (Gur et al, 2002b) and this paradigm has already been successfully used in previous behavioral and neuroimaging studies (Gur et al, 2002a;Seiferth et al, 2008).…”

Section: Stimulimentioning

confidence: 99%

“…Furthermore, deficits in emotion processing correlate with the severity of psychotic symptoms (Kohler et al, 2000;Schneider et al, 1995). At the same time, they are relatively stable over the course of disease (Addington and Addington, 1998;Kohler et al, 2003) and were reported to be already present in subjects at risk for psychosis (Habel et al, 2004;Kee et al, 2004;Seiferth et al, 2008;van't Wout et al, 2004). Difficulties in emotion recognition may further be related to deficits in theory of mind and empathy (Langdon et al, 2006;Lee et al, 2004;Shamay-Tsoory et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Neuronal Correlates of Facial Emotion Discrimination in Early Onset Schizophrenia

Seiferth

Pauly

Kellermann

et al. 2008

Neuropsychopharmacol

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Emotion discrimination deficits represent a well-established finding in schizophrenia. Although imaging studies addressed the cerebral dysfunctions underlying emotion perception in adult patients, the question of trait vs state characteristics is still unresolved. The investigation of juvenile patients offers the advantage of studying schizophrenia at an age where influences of illness course and long-term medication are minimized. This may enable a more detailed characterization of emotion discrimination impairments and their cerebral correlates with respect to their appearance and exact nature. A total of 12 juvenile patients with early onset schizophrenia and matched healthy juveniles participated in this study. fMRI data were acquired during an emotion discrimination task consisting of standardized photographs of faces displaying happy, sad, angry, fearful, or neutral facial expression. Similar to findings in adult patients, juvenile patients exhibited reduced performance specificity whereas sensitivity was unaffected. Independent of the valence, their processing of emotional faces was associated with hypoactivations in both fusiform gyri and in the left inferior occipital gyrus. In addition, hyperactivations in patients were found in the right cuneus common to happy, angry, and fearful faces. Further, most distinct changes were present in juvenile patients when processing sad faces. These results point to a dysfunction in cerebral circuits relevant for emotion processing already prominent in adolescent schizophrenia patients. Regions affected by a decrease in activation are related to visual and face processing, similar to deficits reported in adult patients. These changes are accompanied by hyperactivations in areas related to emotion regulation and attribution, possibly reflecting compensatory mechanisms.

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Section: Decreased Activation During Facial Emotion Processing In Juvsupporting

confidence: 87%

Section: Decreased Activation During Facial Emotion Processing In Juvsupporting

confidence: 55%

Section: Stimulimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neuronal Correlates of Facial Emotion Discrimination in Early Onset Schizophrenia

Seiferth

Pauly

Kellermann

et al. 2008

Neuropsychopharmacol

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“…Therefore, people with high and low resting HRV appear to show different activations in brain areas associated with the visual processing for neutral and fearful faces. A recent neuroimaging study showed that people with high risk of psychosis showed greater activations in the middle occipital gyrus and the cuneus in response to neutral stimuli during the emotion discrimination task, which was also observed in schizophrenic patients (Seiferth et al, 2008). The present study indicates that people with low resting HRV show heightened activities in similar brain areas for neutral face stimuli.…”

Section: Discussionsupporting

confidence: 80%

Individual differences in cardiac vagal tone are associated with differential neural responses to facial expressions at different spatial frequencies: An ERP and sLORETA study

Park¹,

Moon²,

Kim

et al. 2012

Cogn Affect Behav Neurosci

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A previous study has shown that greater cardiac vagal tone, reflecting effective self-regulatory capacity, was correlated with superior visual discrimination of fearful faces at high spatial frequency Park et al. (Biological Psychology 90:171-178, 2012b). The present study investigated whether individual differences in cardiac vagal tone (indexed by heart rate variability) were associated with different event-related brain potentials (ERPs) in response to fearful and neutral faces. Thirty-six healthy participants discriminated the emotion of fearful and neutral faces at broad, high, and low spatial frequencies, while ERPs were recorded. Participants with low resting heart rate variability-characterized by poor functioning of regulatory systems-exhibited significantly greater N200 activity in response to fearful faces at low spatial frequency and greater LPP responses to neutral faces at high spatial frequency. Source analyses-estimated by standardized low-resolution brain electromagnetic tomography (sLORETA)-tended to show that participants with low resting heart rate variability exhibited increased source activity in visual areas, such as the cuneus and the middle occipital gyrus, as compared with participants with high resting heart rate variability. The hyperactive neural activity associated with low cardiac vagal tone may account for hypervigilant response patterns and emotional dysregulation, which heightens the risk of developing physical and emotional problems.

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Predicting Psychosis

Fusar‐Poli¹

2012

Arch Gen Psychiatry

1,195

387

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Increased neural response related to neutral faces in individuals at risk for psychosis

Cited by 129 publications

References 50 publications

Neuronal Correlates of Facial Emotion Discrimination in Early Onset Schizophrenia

Neuronal Correlates of Facial Emotion Discrimination in Early Onset Schizophrenia

Individual differences in cardiac vagal tone are associated with differential neural responses to facial expressions at different spatial frequencies: An ERP and sLORETA study

Predicting Psychosis

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