Increased Myocardial Retention of Mesenchymal Stem Cells Post-MI by Pre-Conditioning Exercise Training

Vieira, Stella Souza; Antônio, Ednei Luiz; Melo, Brunno Lemes de; Santos, Luis Felipe Neves Dos; Sant’Ana, Eduardo; Feliciano, Regiane dos Santos; Marques, Fábio Luiz Navarro; Faria, Daniele de Paula; Buchpiguel, Carlos Alberto; Silva, José Antônio da; Tucci, Paulo José Ferreira; Serra, Andrey Jorge

doi:10.1007/s12015-020-09970-z

Cited by 4 publications

(3 citation statements)

References 51 publications

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“…Fisher-344 female rats who were trained nine weeks prior to myocardial infarction (MI), followed by AD-MSCs transplantation, showed improved morphological and functional LV parameters, inhibition of myocardial hypertrophy and fibrosis, and decreased proinflammatory cytokines in the myocardium as compared to sham MI rats [198]. Interestingly, CR altered the transcriptional profile of skeletal muscle in a manner similar to that of individuals [199].…”

Section: Interplay Between 'Rejuvenating' Treatments and Msc Senescencementioning

confidence: 99%

Mesenchymal Stem Cell Senescence during Aging:From Mechanisms to Rejuvenation Strategies

Jiang¹,

Li²,

Ge³

et al. 2023

Aging and disease

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In cell transplantation therapy, mesenchymal stem cells(MSCs)are ideal seed cells due to their easy acquisition and cultivation, strong regenerative capacity, multi-directional differentiation abilities, and immunomodulatory effects. Autologous MSCs are better applicable compared with allogeneic MSCs in clinical practice. The elderly are the main population for cell transplantation therapy, but as donor aging, MSCs in the tissue show aging-related changes. When the number of generations of in vitro expansion is increased, MSCs will also exhibit replicative senescence. The quantity and quality of MSCs decline during aging, which limits the efficacy of autologous MSCs transplantation therapy. In this review, we examine the changes in MSC senescence as a result of aging, discuss the progress of research on mechanisms and signalling pathways of MSC senescence, and discuss possible rejuvenation strategies of aged MSCs to combat senescence and enhance the health and therapeutic potential of MSCs.

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Section: Interplay Between 'Rejuvenating' Treatments and Msc Senescencementioning

confidence: 99%

Mesenchymal Stem Cell Senescence during Aging:From Mechanisms to Rejuvenation Strategies

Jiang¹,

Li²,

Ge³

et al. 2023

Aging and disease

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“…This examination was performed at study completion (i.e., 29 days) using an HP SONOS 5500 machine, while the animals were still under anaesthesia, with a mixture of ketamine (50 mg/kg) and xylazine (10 mg/kg), i.p. (Grandinetti et al, 2019;Souza Vieira et al, 2020). The areas of the left ventricle (LV) at completion of the diastole and systole were analysed in the bidimensional mode.…”

Section: Echocardiographymentioning

confidence: 99%

A common oral pathogen Porphyromonas gingivalis induces myocarditis in rats

Peron

Prates

Antônio

et al. 2022

J Clinic Periodontology

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Aim: To evaluate whether Porphyromonas gingivalis (P. gingivalis) inoculation could induce cardiac remodelling in rats. Materials and Methods:The study was conducted on 33 Wistar rats, which were distributed in the following experimental groups: not inoculated; inoculated with 1 Â 10 8 CFU/ml of bacteria; inoculated with 3 Â 10 8 CFU/ml of bacteria. The animals were inoculated at baseline and on the 15th day of follow-up. Blood collection was performed at baseline and 60 min after each inoculation. At 29 days, the animals were subjected to echocardiography and at 30 days to haemodynamic studies before sacrificing them.Results: Impact of the bacteria was more evident in rats that received higher P. gingivalis concentration. Thus, 3 Â 10 8 CFU/ml of bacteria increased the rectal temperature and water content in the lung as well as myocardial necrosis and fibrosis. P. gingivalis induced the intensification of DNA fragmentation and increased the levels of malondialdehyde, oxidized proteins, and macrophage expression in the myocardium. These findings were associated with lower LV isovolumetric relaxation time, +dP/dt, -dP/dt, and higher end-diastolic pressure.Conclusions: P. gingivalis bacteraemia is significantly associated with adverse cardiac remodelling and may play a biological role in the genesis of heart failure.

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“…Mesenchymal stem cells (MSCs) are widely used in several diseases, such as osteoarthritis, osteogenesis imperfecta, articular cartilage defects, and bone fracture (1–4). Results from our research group illustrate that the MSCs therapy increased myocardial vascularization, prevented infarct expansion, and attenuated cardiac dysfunction in rats with heart failure (3–6).…”

Section: Introductionmentioning

confidence: 99%

Light‐emitting Diode Can Enhance the Metabolism and Paracrine Action of Mesenchymal Stem Cells

Mansano

Rocha

Teixeira

et al. 2023

Photochem & Photobiology

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This study investigated the influence of red light‐emitting diodes (LED, 630 nm) on different irradiation parameters and the number of applications on mesenchymal stem cells derived from adipose tissue (AdMSCs) metabolism and paracrine factors. The AdMSCs were irradiated with a LEDbox device (output power: 2452.5 mW; laser beam: 163.5 cm2; irradiance: 15 mW cm−2) using radiant exposures of 0.5, 2, and 4 J cm−2, respectively. AdMSCs were irradiated once or every 48 h up to three irradiations. All molecular analyses were performed 24 h after the last irradiation. LED did not induce changes in cell count, DNA damage, and oxidative stress. A significant repercussion of the LED has been noticed after three irradiations with 4 J cm−2. AdMSCs had higher levels of IL‐6, IGF‐1, and NOx index. A higher ATP content and MMT/Resazurin assay were identified in AdMSCs irradiated three times with 4 J cm−2. Mitochondrial basal respiration, maximal respiration and proton leak under metabolic stress were reduced by 0.5 and 2 J cm−2 irradiations. These data showed that three LED irradiations with 4 J cm−2 may be a suitable parameter for future AdMSCs therapy because of its improved metabolic activity, ATP content, and IL‐6, IGF‐1, and nitric oxide secretion.

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Increased Myocardial Retention of Mesenchymal Stem Cells Post-MI by Pre-Conditioning Exercise Training

Cited by 4 publications

References 51 publications

Mesenchymal Stem Cell Senescence during Aging:From Mechanisms to Rejuvenation Strategies

Mesenchymal Stem Cell Senescence during Aging:From Mechanisms to Rejuvenation Strategies

A common oral pathogen Porphyromonas gingivalis induces myocarditis in rats

Light‐emitting Diode Can Enhance the Metabolism and Paracrine Action of Mesenchymal Stem Cells

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