Increased mortality associated with meticillin-resistant Staphylococcus aureus (MRSA) infection in the Intensive Care Unit: results from the EPIC II study

Abstract

patients with MSSA infections. There were no significant differences between the two groups in use of mechanical ventilation or haemofiltration/haemodialysis. Cancer and chronic renal failure were more prevalent in MRSA than in MSSA patients. ICU mortality rates were 29.1% and 20.5%, respectively (P < 0.01) and corresponding hospital mortality rates were 36.4% and 27.0% (P < 0.01). Multivariate analysis of hospital mortality for MRSA infection showed an adjusted OR of 1.46 (95% CI 1.03-2.06) (P = 0.03). In ICU patients, MRSA infection is therefore independently associated with an almost 50% higher likelihood of hospital death compared with MSSA infection.

Pharmacodynamic Profile of GSK2140944 against Methicillin-Resistant Staphylococcus aureus in a Murine Lung Infection Model

“…hile a recent CDC surveillance study reports a decrease in health care-associated invasive methicillin-resistant Staphylococcus aureus (MRSA) infections in the United States from 2005 through 2011 (1), it remains a prevalent pathogen causing hospital-acquired (HAP) and ventilator-associated pneumonia (VAP) (2) and represents a major health threat with significant mortality rates (3,4). Until lately, most cases of health care-associated pneumonia (HCAP), HAP, and VAP were thought to be caused by the hospital-acquired MRSA (HA-MRSA) strains, but a second variant of MRSA, community-acquired MRSA (CA-MRSA), has emerged in health care settings as a cause of severe pneumonia (2,4).…”

Population-Based Study of the Increased Incidence of Skin and Soft Tissue Infections and Associated Antimicrobial Use

“…Between the 1960s and the 1990s, the majority of methicillin-resistant Staphylococcus aureus (MRSA) infections were seen in hospitals (7,12,39). Studies have clearly demonstrated that hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) infections result in excess mortality in hospitalized patients (6,17). Although strict infection control, hand hygiene, and antibiotic use have kept the incidence of HA-MRSA infections steady within hospitals, a number of countries around the world, including Canada, have now reported increasing rates of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections (16,30,32,35).…”

Progress on Antimicrobial Surgical Gloves: A Review

“…[24][25][26] Dramatic microbial multidrug resistance related to an increase in health care infections, such as methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococci (VRE), has created a demand for a new alternative prevention material. 27,28 The application of antimicrobial gloves in all health care units (e.g., operating theatres, wards, clinics) will help to reduce the possibility of microbes' horizontal spread and prevent HAIs.…”