Increased methylglyoxal and advanced glycation end products in kidney from spontaneously hypertensive rats

Abstract

MG and AGEs formation was significantly elevated in kidney from SHR, which may cause local vascular and tubular damage, contributing to the development and complications of hypertension.

Association Study between Hypertension and A/G Polymorphism at Codon 637 of the Transporter Associated with Antigen Processing 1 Gene

“…An A-to-G transition of the TAP1 gene at codon 637 would lead to replacement of Asp-637 by glycine (19), and such a replacement may play an important role in the assembly of class I molecules and presentation of endogenous peptides (derived from the nucleus and cytosole) to CD8 (+) T cells. Glycosylation of TAP1 may be involved in pathomechanism of the dysfunction of artery endothelium in patients with hypertension (6,7,12,13,20). In the present study, we attempted to find an association between the A/G polymorphisms at codon 637 of the TAP1 gene and essential hypertension.…”

“…Accordingly, this evidence suggests that the alteration of genotype AA or AG to GG may play a potential role in blood pressure increase. So, the TAP gene should be considered a potential candidate gene for cause of cardiovascular disease except autoimmune disease, infectious disease and tumors (6,7,12,13).…”

“…The glycosylation of TAP could severely influence its immune function and also initiate glycosylation-related oxidative stress impairment (6,7), which maybe correlate to pathomechanism of dysfunction of the artery endothelium in patients with hypertension (8)(9)(10).…”

Aging: Drugs to Eliminate Methylglyoxal, a Reactive Glucose Metabolite, and Advanced Glycation Endproducts

“…Despite the efficient glyoxalase system, MG levels can increase significantly in the plasma and different organs such as the aorta and the kidneys [61,[63][64][65][66]. We have shown that MG levels are elevated in the plasma, aorta and kidney of fructose-fed Sprague-Dawley rats and spontaneously hypertensive rats (SHR) [61,[63][64][65].…”

“…We have shown that MG levels are elevated in the plasma, aorta and kidney of fructose-fed Sprague-Dawley rats and spontaneously hypertensive rats (SHR) [61,[63][64][65]. Patients with type 1 and type 2 diabetes have 2-6 fold higher plasma levels of MG compared to healthy people [67,68].…”